The eyes of the NFL will turn to Empower Field at Mile High for a star-studded showdown on Sunday Night Football. The Denver Broncos host the San Francisco 49ers in a battle between 1-1 teams. The Broncos defeated the Houston Texans in Week 2. The 49ers knocked off the Seattle Seahawks last week, overcoming the injury to Trey Lance and the reinsertion of Jimmy Garoppolo as the team's starting quarterback.

Kickoff is set for 8:20 p.m. ET. San Francisco is favored by 1.5 points in the latest 49ers vs. Broncos odds from Caesars Sportsbook, and the over/under is 45. Before making any Broncos vs. 49ers picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Niners and just locked in its picks and SNF predictions. You can visit SportsLine now to see the picks. Here are the NFL odds and betting lines for Niners vs. Broncos:

  • Broncos vs. 49ers spread: San Francisco -1.5
  • Broncos vs. 49ers over/under: 45 points
  • Broncos vs. 49ers money line: Denver +105, San Francisco -125
  • SF: The 49ers are 6-1 ATS in their last seven games overall
  • DEN: The Under is 6-0 in Broncos' last six games in September
  • Broncos vs. 49ers picks: See picks here
Featured Game | Denver Broncos vs. San Francisco 49ers

Why the Broncos can cover

Denver's defense has been playing disciplined football to start the 2022 campaign. While the offense is looking to find its groove, the defense has shown its ability to lockdown opposing offenses. They are currently ranked fourth in the league in total defense (243.5), fifth in passing yards (165.5), and fourth in rushing yards allowed (78). Denver is also tied for third in the league in points allowed (13). 

This group is able to get after the passer, recording five total sacks. Dre'Mont Jones and Bradley Chubb are tied for first on the team with two sacks apiece. Patrick Surtain II is a lockdown, press corner who can thrive in man or zone coverage. The Alabama product has fluid movement in his hips while staying extremely disciplined. He has all the tools needed to line up against a No. 1 receiving option. 

Why the 49ers can cover 

Garoppolo is the signal-caller under center for San Francisco again. Garoppolo brings a veteran presence to the field with familiarity with San Francisco's offensive system. The Eastern Illinois product has a 31-14 record with the 49ers. Garoppolo can get the ball out quickly with his fast and compact release. He stepped in admirably last week, completing over 60% of his passes for 154 yards and a score. 

Wide receiver Brandon Aiyuk looks to become more of a reliable option in the passing game. Aiyuk owns great speed and explosiveness with strong hands. The Arizona State product is a legitimate threat with the ball in his hands. He's leading the team with seven receptions for 103 yards, a 14.7 yards per reception average. 

How to make Broncos vs. 49ers picks

SportsLine's model is leaning Under on the total, projecting the teams to combine for 42 points. It also says one side of the spread hits in more than 50% of simulations. You can only get the model's SNF picks at SportsLine

So who wins 49ers vs. Broncos on Sunday Night Football? And which side of the spread hits over 50% of the time? Visit SportsLine now to see which side of the 49ers vs. Broncos spread to jump on, all from the advanced model that is up more than $7,000 on NFL picks, and find out.