When the 49ers drafted Trey Sermon, many thought he would be the team's running back of the present and the future. Instead, he's been glued to the bench, and in his place, fifth-round rookie Elijah Mitchell has been San Francisco's primary back. Mitchell ranks fifth in the league with 78.2 rushing yards per game and runs like a player who isn't eager to cede his role atop the depth chart. With how much coach Kyle Shanahan likes to run the ball, Mitchell carries plenty of appeal for your NFL DFS picks.
Is there another San Francisco running back to keep an eye on for 49ers vs. Rams NFL DFS tournaments and cash games? Jeff Wilson, who led the team in rushing last year, was just activated off the PUP list, but has yet to play a snap this season. He's likely ahead of Sermon on the depth chart, but can he get enough touches to warrant consideration for your NFL DFS lineups? Before locking in your NFL DFS picks for Monday Night Football and beyond, be sure to check out the NFL DFS advice, strategy and projections from SportsLine daily Fantasy expert Mike McClure.
McClure is a legendary professional DFS player with almost $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1 percent in more than a dozen other tournaments last season.
He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.
Top NFL DFS picks for Rams vs. 49ers
One of McClure's top NFL DFS picks for Monday Night Football is Rams quarterback Matthew Stafford. An MVP-contender, Stafford didn't have his best game last week, but still threw for 294 yards and a touchdown against the Titans. He still leads the NFL in passer rating (111.0) and in QBR (69.7).
Stafford is on pace to throw for a career-high in yards and ranks third among quarterbacks in Fantasy points. On Monday Night Football, he will face a defense that has allowed the fourth-most Fantasy points to opposing quarterbacks. San Francisco just allowed backup Colt McCoy pass for 249 yards, one touchdown and no interceptions.
Part of McClure's optimal NFL DFS strategy also includes rostering 49ers receiver Brandon Aiyuk. A 2020 first-rounder, Aiyuk had a slow start to the season, but has picked up his production recently. His best two yardage games have come in the last two weeks, highlighted by him posting a 6-89-1 stat line against Arizona in Week 9.
Last week's game was also encouraging in the fact that Aiyuk played more snaps and had more catches than No. 1 receiver Deebo Samuel. The Niners have been searching for more balance among their wideouts, and the game against the Cardinals was promising in that regard. Aiyuk has played the Rams just once before, but he scored a touchdown in that game and has a shot at finding the end zone again on Monday Night Football.
How to set NFL DFS lineups for Rams vs. 49ers
McClure is also targeting an undervalued player who is set to explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is here.
So who is Mike McClure putting in his optimal NFL DFS lineups for Monday Night Football? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a daily Fantasy expert with nearly $2 million in winnings, and find out.