The Cowboys enter the 2022 NFL playoffs as the hottest offense in the league, scoring more than 50 points in two of their final three regular-season games. The Cowboys are coming off a 51-26 win at Philadelphia in Week 18 and will host one of the top defensive teams in the league on Sunday afternoon. The 49ers will visit AT&T Stadium during NFL Wild Card Weekend 2022. Dallas is listed as a three-point favorite in the latest Wild Card Weekend NFL odds from Caesars Sportsbook.

The Cowboys have been one of the most profitable teams in the NFL this season, covering their NFL spreads in 13 of their 17 games. Will their success carry over to the NFL playoffs 2022? All of the Wild Card Weekend NFL lines are listed below and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Wild Card Weekend NFL picks now.

The model, which simulates every NFL game 10,000 times, is up over $7,400 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters the 2021 NFL playoffs on an incredible 136-97 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Super Wild Card Weekend 2022 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Wild Card Weekend NFL predictions

One of the model's strongest Wild Card Weekend picks is that the NFC's No. 2 seeded Tampa Bay Buccaneers (-7.5) cover the spread at home against the No. 7 Eagles.

The Buccaneers have won seven of their last eight games, including a three-game winning streak to close out the regular season. They blew out Carolina in a 41-17 final last Sunday, easily covering the 11-point spread. Veteran quarterback Tom Brady completed 29 of 37 passes for 326 yards and three touchdowns.

Brady leads a Tampa Bay offense that ranks second in the NFL, averaging 405.9 yards per game. Philadelphia has exceeded expectations this year, but its running game and defense will not be enough to keep pace with one of the best offenses in the league. The Buccaneers have covered the spread in six of their last eight games and won 10 of their last 11 home games.

SportsLine's model is projecting another strong day for Brady, as the simulations have him throwing for nearly 300 yards and at least two touchdowns.

How to make Super Wild Card Weekend NFL picks

The model has also made the call on who wins and covers in every other game on the Wild Card Weekend schedule, and it's calling for one team to cover in nearly 60 percent of simulations. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which team is a must-back? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,400 since its inception, and find out.

Wild Card Weekend NFL odds, spreads, lines, schedule

Sunday, Jan. 16

Eagles at Buccaneers (-7.5, 46)

Featured Game | Tampa Bay Buccaneers vs. Philadelphia Eagles

49ers at Cowboys (-3, 51)

Featured Game | Dallas Cowboys vs. San Francisco 49ers

Steelers at Chiefs (-12.5, 46)

Featured Game | Kansas City Chiefs vs. Pittsburgh Steelers

Monday, Jan. 17

Cardinals at Rams (-3.5, 50)

Featured Game | Los Angeles Rams vs. Arizona Cardinals