The Green Bay Packers come out of a bitter defeat that raised red flags, but they will try to right the ship on Thursday Night Football against the San Francisco 49ers. Green Bay (5-2) is in first place in the NFC North, but a 28-22 loss to the Vikings exposed the team's run defense and a lack of weapons for quarterback Aaron Rodgers. San Francisco (4-4) is even more banged up, and a 37-27 loss to Seattle in Week 8 cost them All-Pro tight end George Kittle and starting quarterback Jimmy Garoppolo, who both will miss extended time.

Kickoff is scheduled for 8:20 p.m. ET at Levi's Stadium. William Hill lists Green Bay as a 6.5-point favorite in the latest Packers vs. 49ers odds, while the over-under for total points scored is 48.5. Before making any 49ers vs. Packers picks, check out what SportsLine's resident Green Bay expert, R.J White, has to say.

CBS Sports' NFL editor, White enters Week 9 as SportsLine's hottest expert. He's on a sizzling 27-14 run against the spread that's returned his followers $1,145. And it's no surprise, as White twice has cashed huge in the world's most prestigious football handicapping competition, the Las Vegas SuperContest.

In addition, White has a particularly keen eye for the Packers. In fact, he is an astounding 39-8 in his last 47 spread picks for or against the Packers. Anyone who has followed his NFL picks is way up.

Now, White has looked at Packers vs. Niners from every possible angle. You can head to SportsLine to see his picks. Here are the NFL odds from William Hill and trends for Niners vs. Packers:

  • Packers vs. 49ers spread: Green Bay -6.5
  • Packers vs. 49ers over-under: 48.5
  • Packers vs. 49ers money line: Green Bay -300, San Francisco +250
  • GB: QB Aaron Rodgers has thrown for at least 283 yards in five of the seven games.
  • SF: Rookie WR Brandon Aiyuk has 14 catches for 206 yards over the past two games.

Why the Packers can cover

Rodgers is 9-3-1 against the spread in Thursday games in his career, and he can always count on receiver Davante Adams. The explosive wideout has missed two games but has 502 yards on 43 catches, and he has five TDs after scoring three times last week. Rodgers is third in the league with 20 touchdown passes and has thrown just two interceptions. Wide receiver Marquez Valdes-Scantling has been quiet recently, but he averages 16.3 yards per catch. 

Tight end Robert Tonyan has stepped up with the receiving corps thin, posting 309 yards, including 79 last week, and five scores.

The Packers are 19-7-1 against the spread in their last 27 games after allowing more than 150 rushing yards in their previous game, and the 49ers are perilously thin at running back. Green Bay should be able to force it into Nick Mullens' hands, and linebacker Za'Darius Smith (six sacks) should be able to pressure him against a line that has yielded 22 sacks. 

Why the 49ers can cover

Underdogs are 6-0 against the spread since Week 2 in this season's Thursday night games, and Nick Mullens has been reliable while filling in for Garoppolo. He has completed more than 70 percent of his passes for 852 yards in four games.

The Packers' defense averages 8.0 pressures per game this season, fewest in the NFL, and Mullens can find receivers when given time. Since 2018, he leads all quarterbacks in yards per attempt (9.6) when not pressured. Running back Jamycal Hasty, who has 113 yards (4.4 per rush) over the past three games, could also exploit a weak Packers run defense that Cook lit up for 163 yards and three scores last week.

How to make Packers vs. 49ers picks

White has analyzed this matchup from all sides and he is leaning over on the total. He also has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing it here

So who wins 49ers vs. Packers on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine right now to find out which side of the Packers vs. 49ers spread you should be all over, all from the expert who's 39-8 on Green Bay picks, and find out.