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The ninth-ranked Villanova Wildcats (7-3) and Creighton Bluejays (8-3) face off in a Big East battle on Friday night. Both teams were handed a loss in their last contest. Villanova fell to No. 1 Baylor, while Creighton lost to Arizona State. The Wildcats have dominated this series in recent years, winning seven of the last 10 meetings against Creighton. 

Tip-off is at 8 p.m. ET from Chi Health Center. Villanova is a 6.5-point favorite, while the over-under or total number of points Vegas thinks will be scored, is 134 in the latest Villanova vs. Creighton odds. Before locking in any Creighton vs. Villanova picks, be sure to check out the college basketball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $2,400 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Villanova vs. Creighton and revealed its coveted picks and predictions. You can head to SportsLine now to see all of the model's CBB picks. Here are several college basketball odds and betting lines for Villanova vs. Creighton:

  • Villanova vs. Creighton spread: Villanova -6.5 
  • Villanova vs. Creighton over-under: 134 points 
  • Villanova vs. Creighton money line: Villanova -280, Creighton +230 
  • NOVA: The Wildcats are 9-2-1 ATS in their last 12 Friday games 
  • CREI: The Bluejays are 5-1 ATS in their last 6 Friday games
Featured Game | Creighton Bluejays vs. Villanova Wildcats

Why Villanova can cover

Guard Collin Gillespie is averaging a team-high 16.2 points, 3.2 rebounds, with 3.4 assists. Gillespie has been one of the best 3-point shooters for the Wildcats. He is shooting 43 percent from downtown. The Pennsylvania native has scored over 20 points in three games this year. In the win against Saint Joseph's, Gillespie finished with 23 points, four rebounds, and three assists. He also shot 5-of-7 from deep. 

Forward Jermaine Samuels is logging 11 points per game with a team-high 6.3 rebounds. Samuels has scored at least 10 points in seven games thus far. Samuels recorded a double-double in the win against No. 18 Tennessee, finishing with 14 points and 11 boards. 

Why Creighton can cover

The Bluejays are one of the most efficient teams in the Big East. They rank second in field goal percentage (.482) while averaging 71.9 points per game. Senior forward Ryan Hawkins is leading the team with 13.7 points and 6.8 rebounds per contest. The Iowa native dropped 25 points in back-to-back games against Iowa State and BYU

Freshman guard Ryan Nembhard is averaging 12.5 points, 3.4 rebounds, and 4.9 assists. Nembhard started his freshman campaign with six straight double-digit scoring performances. The Ontario native scored a season-high 22 points in the win against Nebraska. Nembhard is also shooting a team-high 42 percent from downtown. 

How to make Villanova vs. Creighton picks

SportsLine's model is leaning over on the point total, projecting the teams to combine for 143 points. The model also says one side of the spread hits in well over 60 percent of simulations. You can only see the model's Villanova vs. Creighton picks at SportsLine.

So who wins Villanova vs. Creighton? And which side of the spread hits in well over 60 percent of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college basketball picks, and find out.