The New York Yankees will try to bounce back from dropping two games on Sunday when they open a three-game series against the Baltimore Orioles on Monday. The Yankees (29-12), who have the best record in the majors, are trying to avoid their first three-game losing streak of the season. Meanwhile, the Orioles (17-25) sit at the bottom of the AL East, 12.5 games behind the Bronx Bombers. New York is a heavy -310 money-line favorite in the latest Yankees vs. Orioles odds from Caesars Sportsbook, while Baltimore is a +255 underdog. 

First pitch is set for 7:05 p.m. ET form Yankee Stadium in the Bronx, N.Y. The game is one of 12 on the MLB schedule on Monday. Elsewhere in the majors, four of the best teams in the National League square off when the San Diego Padres (27-14) host the Milwaukee Brewers (26-15) and the Mets (28-15) visit the Giants (22-18). Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Monday. All the games occur at 6:35 p.m. ET or later, so there's still plenty of time to make these MLB picks. If you successfully parlay the picks, you'd be looking at a payout of well over 26-1. You can only see the model's MLB picks at SportsLine.

Top MLB picks today

The model, which crunched the numbers of each game on Monday 10,000 times, is picking Oakland (+150) to defeat Seattle at 9:40 p.m. ET (see tickets at StubHub). A popular wiseguy choice to win the AL West prior to the season, the Mariners (17-25) have struggled, losing four straight and five of their last six as they sit in fourth place in the division. They are coming off a four-game sweep at the hands of the Red Sox in Boston.

Seattle has had difficulty against left-handers this season, going 2-9, and faces A's southpaw Zach Logue (2-2, 2.04, 1.19 WHIP) on Monday. Meanwhile Oakland is a respectable 6-6 against lefties and takes on Mariners southpaw Marco Gonzales (2-4, 3.08, 1.50).

The model also likes that Oakland is a better team on the road (11-12 record) than at home (6-14). 

Featured Game | Seattle Mariners vs. Oakland Athletics

How to make MLB picks and parlays for Monday

The model also locked in three other best bets for Monday, including a must-see play an an underdog who wins outright almost 60 percent of the time. You can see the model's MLB best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of well over 26-1? And what underdog does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 41-30 roll on top-rated MLB money-line picks through six weeks.