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The New York Yankees and Baltimore Orioles play the rubber match of their three-game series when the AL East rivals square off on Wednesday at Yankee Stadium in the Bronx. On Monday the Orioles shocked the Yankees in a 6-4 victory. New York bounced back on Tuesday with a 7-6 win in 11 innings. JP Sears (1-0, 0.00 ERA) takes the mound for New York and faces Tyler Wells (1-3, 4.41).

New York is a -160 money-line favorite in the latest Yankees vs. Orioles odds from Caesars Sportsbook, while Baltimore is a +140 underdog. First pitch is set for 7:05 p.m. ET and the game is one of 13 on the MLB schedule for Wednesday. Elsewhere in the majors, the Red Sox look to win their seventh straight game, against the White Sox, and the Astros and Guardians play the rubber match of their three-game series in Houston. Before making any MLB picks or parlays, be sure to check out the baseball predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in three confident MLB best bets for Wednesday. If you successfully parlay the picks, you'd be looking at a payout of well over 16-1. You can only see the model's MLB picks at SportsLine. 

Top MLB picks today

The model, which ran 10,000 simulations on each of Wednesday's 13 games, is taking Texas (+155) to defeat the Los Angeles Angels at Angel Stadium in Anaheim, Calif. The Rangers have had success against the Halos this season, sweeping L.A. in Texas last week. Texas scored 23 runs in that three-game sweep.

The Rangers lineup is full of hitters who have hit Angels starter Reid Detmers (2-1, 4.15) this season. Kole Calhoun has a home run and two RBI in two at-bats against Detmers. Corey Seager has two hits, including a homer, in six at-bats. Four other Texas hitters are hitting at least .333 against the L.A. lefty.

Featured Game | Los Angeles Angels vs. Texas Rangers

How to make Wednesday MLB parlays

The model also locked in two other best bets for Wednesday, including a play on a big underdog. You can only see the model's MLB Wednesday best bets and parlay at SportsLine. 

What MLB picks should you target for a payout of well over 16-1? And what big underdog does the model like on Wednesday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 41-30 roll on top-rated MLB money-line picks through seven weeks, and find out.