A pair of Thanksgiving Day traditions continue on Thursday as the Detroit Lions and Dallas Cowboys host games during the 2022 NFL Thanksgiving schedule. Detroit (4-6), which is playing on the holiday for the 83rd time dating back to 1934, hosts the Buffalo Bills (7-3) at 12:30 p.m. ET in the first game of an NFL tripleheader. The Cowboys (7-3) take on the NFC East-rival New York Giants (7-3) at 4:30 p.m. ET as they participate in a Thanksgiving game for the 55th time and serve as hosts for a 45th consecutive year. The three-game slate concludes when the New England Patriots (6-4) visit the Minnesota Vikings (8-2) at 8:20 p.m. ET.

The latest Week 12 NFL odds from Caesars Sportsbook have Buffalo favored by 9.5 against Detroit. The Cowboys are 9-point favorites at home and Minnesota is favored by 2.5 in the nightcap. Before locking in your 2022 Thanksgiving Day NFL picks and parlays, be sure to check out the latest 2022 Thanksgiving Day NFL parlay from the proven computer model at SportsLine.

The SportsLine Projection Model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four ties during that span. Anyone who has followed it is way up.

Now, the model has intensely examined the latest NFL odds and betting lines, and its picks and predictions are in. If you successfully parlay its picks, you'd be looking at a massive payout of almost 50-1. You can only see the model's Thanksgiving Day NFL picks at SportsLine.

Top Thanksgiving Day 2022 NFL predictions

One key piece to the 2022 Thanksgiving Day NFL parlay: The model is backing Over 45.5 in the Cowboys vs. Giants game. Dallas went over this total by itself in its last home game as it recorded a 49-29 victory against Chicago in Week 8. Tony Pollard came up with a huge performance while filling in for an injured Ezekiel Elliott, rushing for 131 yards and three touchdowns, while Dak Prescott threw for a pair of TDs and ran for another.

The Cowboys, who are seventh in the NFL in scoring with an average of 25.1 points, were on fire again last week as they put up 40 in their triumph at Minnesota. Pollard had another big day, leading the team in both rushing (80 yards) and receiving (109) while hauling in two scoring passes. New York combined with Detroit to produce 49 points on Sunday, and 64 were put on the board in its visit to Dallas last season. See which other parlay picks to make here.

How to make Thanksgiving Day NFL picks

The model also has five other Thanksgiving NFL picks, including an against-the-spread play on an underdog. You can only see the model's Thanksgiving Day best bets and parlay at SportsLine

So what are the six 2022 Thanksgiving Day NFL picks that could return a massive payout of almost 50-1 if you parlay them together? Visit SportsLine now to see which NFL bets will give you a Thanksgiving Day to remember, all from the proven model with a history of crushing its NFL picks, and find out.