Despite leading the league with 14 touchdowns, Austin Ekeler was a Pro Bowl snub and has yet to receive that honor in his career. Ekeler, and a Chargers team that saw no offensive players get Pro Bowl recognition, can take their frustrations out on the Colts on Monday Night Football in Indianapolis at 8:15 p.m. ET. Stacking the running back with the likes of Justin Herbert and Keenan Allen may seem like the prudent NFL DFS strategy, but can a new-look Colts squad offer many NFL DFS picks with upside for Monday?

A benched Matt Ryan and an injured Jonathan Taylor means Indy will have a new backfield come Monday. But Michael Pittman Jr. remains a reliable option out wide. Coming off a 90-yard game, is Pittman a name to consider from the MNF DFS player pool? Before making any NFL DFS picks for Colts vs. Chargers on Monday Night Football on sites like DraftKings and FanDuel, be sure to check out the NFL DFS advice and strategy from SportsLine daily Fantasy expert Mike McClure.

McClure is a legendary professional DFS player with over $2 million in career winnings. His methodology has led to enormous cashes on FanDuel and DraftKings. He took down two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top-10 finishes in tournaments with over 130,000 entrants on DraftKings. His lineups also finished inside the top 1% in more than a dozen other tournaments.

He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine.

This year, he's already won the DraftKings Millionaire Maker twice and the FanDuel Million once. Now, McClure has turned his attention to Monday Night Football and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Monday Night Football

One of McClure's top NFL DFS picks for Monday Night Football is Herbert. The third-year pro had his third straight 300-yard passing game last week, also eclipsing 4,000 passing yards on the season in the process. Herbert is now the only player in NFL history with 4,000 passing yards in each of his first three seasons.

One only has to look at last week's collapse by Indy to see what a Pro Bowl-caliber QB can do to the Colts. Minnesota overcame a 33-point deficit thanks, in part, to Kirk Cousins shredding Indianapolis for 460 yards and four scores -- both career highs. Just the week prior, Dak Prescott had three passing touchdowns versus the Colts. Given Indy's recent struggles, combined with Herbert's current surge, you can see why McClure is high on him for MNF DFS lineups.

Part of McClure's optimal NFL DFS strategy also includes stacking Herbert with receiver Mike Williams. Since coming off an injury two games ago, Williams has averaged five grabs for 91.5 yards with 1 total touchdown across his two starts. He appears to be rounding back into the form that made him the WR10 in terms of Fantasy points through the first seven weeks of the season.

Every Chargers receiver has to be licking his chops at a Colts defense that has allowed six TDs to opposing wideouts over the last two games alone. Those six scores have come from five different receivers as Indy's defense is an equal opportunist. Williams has either scored a touchdown or gained 100-plus yards in six of his last eight games with a full complement of snaps, so you can see why McClure is high on him for Monday Night Football. You can see the rest of McClure's NFL DFS advice here.

How to make NFL DFS lineups for Chargers vs. Colts

McClure is also targeting another undervalued player who could explode for huge numbers on Monday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine

Who is Mike McClure including in his optimal NFL DFS lineups? And which under-the-radar player is a must-roster? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who has won over $2 million with his daily Fantasy picks, and find out.