Second place in the NFC East standings is up for grabs when the Dallas Cowboys host the New York Giants as part of the 2022 NFL Thanksgiving Day schedule. The rivals will enter the Thanksgiving NFL 2022 game with identical 7-3 records, although Dallas posted a 23-16 victory at New York in Week 3. The Cowboys bounced back from a deflating overtime loss at Green Bay with a convincing 40-3 triumph at Minnesota last week, ending the Vikings' seven-game winning streak. Meanwhile, the Giants are coming off their second defeat in three contests, a 31-18 home setback against Detroit. Dallas rolled to a 30-3 victory in its only previous Thanksgiving meeting with New York in 1992.

Kickoff from AT&T Stadium is set for 4:30 p.m. ET. Dallas is a 10-point favorite in the latest Cowboys vs. Giants odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any Giants vs. Cowboys picks, you need to see the NFL predictions and betting advice from SportsLine's Advanced Computer Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cowboys vs. Giants and just locked in its picks and Thanksgiving Day NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Giants vs. Cowboys: 

  • Cowboys vs. Giants spread: Dallas -10
  • Cowboys vs. Giants over/under: 45.5 points 
  • Cowboys vs. Giants money line: Dallas -455, New York +345 
  • DAL: Cowboys are 22-8 against the spread in their last 30 games against division-rivals 
  • NYG: Giants are 2-9 ATS in their last 11 meetings with Dallas 
  • Cowboys vs. Giants picks: See picks here
Featured Game | Dallas Cowboys vs. New York Giants

Why the Cowboys can cover

After losing his first two career starts against New York, Dak Prescott has been outstanding in the series. The 29-year-old quarterback has led Dallas to victory in his last nine outings versus the division-rival, throwing 20 touchdown passes and only three interceptions during the streak. Prescott is looking to become the first signal-caller to win 10 straight starts against the Giants since Roger Staubach reeled off 11 consecutive victories from 1974-79.

The Cowboys lead the NFL with 42 sacks and linebacker Micah Parsons has notched 10 to rank third in the league. Dallas registered five sacks in its first meeting with New York this season, with DeMarcus Lawrence, who has recorded one in each of his last three contests, posting three. The Cowboys' defense also is first in the NFL against the pass, allowing an average of 174.5 yards, and has permitted a league-low 16.7 points per game. See which team to pick here.

Why the Giants can cover

Daniel Jones is coming off one of the most productive passing performances of his career, as he threw for 341 yards in last Sunday's 31-18 loss to Detroit. It was the seventh 300-yard outing of the 25-year-old's career and first since Week 4 of last season, when he set a career-high with 402 yards at New Orleans. Jones also ran for 50 yards against the Lions and gained 79 on the ground in the first meeting with the Cowboys this year.

Saquon Barkley led the Giants with 81 rushing yards in the Week 3 loss to Dallas and scored the team's lone touchdown. The 25-year-old was held to a season-low 22 yards on 15 carries last week, but is second in the NFL with 953 and leads the league with 1,163 scrimmage yards. Barkley has registered at least 105 scrimmage yards in three of his four road games this season and posted two of his four 100-yard rushing performances away from home. See which team to pick here.

How to make Cowboys vs. Giants picks

SportsLine's model is leaning Over on the point total, calling for 46 combined points. The model also says one side of the spread has all the value. You can only see the model's NFL picks at SportsLine.

So who wins Giants vs. Cowboys on Thanksgiving Day? And which side of the spread has all the value? Visit SportsLine now to see which side of the Cowboys vs. Giants spread you need to jump on, all from the model on a 155-109 roll on NFL picks, and find out.