Week 13 got off to an early start, as six teams were in action on Thanksgiving. The Chicago Bears rallied to beat the Detroit Lions -- even though quarterback David Blough was impressive in his first NFL start, the Buffalo Bills shocked the Dallas Cowboys in Texas and the New Orleans Saints clinched the NFC South with a win over the Atlanta Falcons. 

There will be 16 teams in action come 1 p.m. ET on Sunday, and six more teams kick off in the 4 p.m. ET hour. There are several important players who will be out or are in danger of missing Sunday's game. Below, you'll find all the notable injury news and notes you need ahead of Week 13 as teams begin to finalize their injury reports.

Packers (-6.5) at Giants

Brown and Bulaga were limited participants in practice on Friday, while Redmond was a full participant. 

With both Engram and Ellison out, Kaden Smith is expected to start at tight end after playing nearly every snap for the Giants in Week 12. He caught five passes for 17 yards and a touchdown last week against the Bears. Tate being ruled out due to a concussion is a big deal for this Giants team. He caught three passes for 33 yards and a touchdown last Sunday and has been rookie quarterback Daniel Jones' No. 1 target.

Redskins at Panthers (-10)

Kerrigan has started every game that Washington has played since he was drafted in 2011. That streak of 139 games will come to an end on Sunday. He's still in concussion protocol and will be unable to suit up this weekend. The four-time Pro Bowler has recorded 24 combined tackles, and 4.5 sacks in 11 games this season. 

Kyle Allen has been sacked nine times over the past two games and it's looking like he will be without Little on Sunday. Moton was limited all week, so it appears he has a good chance to suit up. Reid sat out of practice on Wednesday and returned as a limited participant on Thursday. He sat out on Friday, which leaves us wondering how he's really feeling coming into this weekend. If he can't go, Colin Jones is listed as his backup on the depth chart. 

49ers at Ravens (-5.5)

  • 49ers: DL Dee Ford (quad, hamstring), WR Dante Pettis (knee) OUT; OT Joe Staley (finger), RB Matt Breida (ankle) QUESTIONABLE 
  • Ravens: LB Matthew Judon (ankle), OL Bradley Bozeman (ankle), DT Domata Peko (knee), TE Nick Boyle (ankle), WR Miles Boykin (ankle) QUESTIONABLE

While losing Ford and Pettis for this matchup is noteworthy, tight end George Kittle, wide receiver Emmanuel Sanders, wide receiver Deebo Samuel and kicker Robbie Gould are no longer listed on the injury report and should be good to go against Baltimore. 

The Ravens are relatively healthy, as all players were full participants in practice on Friday with the exception of Boykin. Still, Bozeman, Peko, Boyle and Judon are all listed as questionable. 

Titans at Colts (-2.5)

With Malcolm Butler out for the season due to a broken wrist, Sims had been taking a large amount of snaps over the past couple of weeks. With him out on Sunday, Tye Smith should have a chance to shine. Sharpe was added to the injury report on Saturday.

Hilton has been hampered by his calf injury for weeks, and it appears to be getting worse. He was on a pitch count for last week's game against the Texans and didn't look like himself. He had three receptions for 18 yards and dropped a couple of passes. Hilton practiced as a limited participant on Wednesday, but was held out on Thursday and Friday. The Colts are battling to remain in second place in the AFC South, and Hilton's absence is definitely going to be felt. 

Eagles (-10) at Dolphins

The Eagles could be missing two big offensive playmakers on Sunday, as Howard has been ruled out and Ertz is listed as questionable. Both were limited participants in practice on Friday, and the Eagles promoted practice-squad reserve TE Josh Perkins for emergency depth on Saturday. Wide receiver Nelson Agholor (knee), offensive guard Brandon Brooks (illness), wide receiver Alshon Jeffery (ankle), right tackle Lane Johnson (concussion), left tackle Jason Peters (knee) and quarterback Carson Wentz (right hand) all practiced fully on Friday and are expected to be in the lineup on Sunday. Look for rookie Miles Sanders and ex-Dolphins starter Jay Ajayi to get the bulk of the carries against Miami.

Wide receivers Albert Wilson (hip, chest) and Allen Hurns (ankle) were limited in practice to start the week, but both were full participants on Friday. Webster was a full participant in practice on Friday as well, while Crawley and Parker were limited. All things considered, things look pretty good this week for the already banged-up Dolphins. 

Buccaneers (-1.5) at Jaguars

After playing in his first game since early November last week, Nassib is again questionable due to an illness. He did not practice at all this week. Jason Pierre-Paul (knee) didn't practice on Wednesday, but Bruce Arians says that he will play on Sunday.

Harrison has been ruled out due to a concussion. He did not practice all week. The Jaguars are in danger of missing Herndon in the secondary as well, as he was limited on Friday due to a shoulder injury. 

Jets (-3) at Bengals

All players listed as questionable for the Jets participated in practice this week in some capacity. Mosley will miss yet another game, and you have to wonder if he will return at all this season. According to Rich Cimini, Brandon Shell should start for Edoga at right tackle. 

Green was again sidelined in practice this week due to his ankle injury. He's yet to play in a game this season for the winless Bengals. Tyler Boyd and Auden Tate figure to get most of Andy Dalton's targets this week. 

Browns (-2) at Steelers

Murray will miss his fifth straight game due to a knee injury. Vernon has a shot to return since suffering a knee injury in the Browns' Week 9 matchup against the Broncos. Robinson remains in concussion protocol and will sit out once again. Freddie Kitchens also said that the Browns won't activate David Njoku from IR despite the TE saying he's finally ready to play. Odell Beckham Jr. was limited in practice at the beginning of the week due to a groin injury, but it appears he will be fine for Sunday. On Saturday, the Browns announced Randall, who was fined for a helmet-to-helmet hit in the first meeting between these teams, would be held out.

Smith-Schuster sported a "sizable brace" on Wednesday and he has been ruled out for Sunday. Conner is also doubtful, which means Jaylen Samuels and Benny Snell could receive the majority of carries in the backfield. Quarterback Devlin Hodges has his work cut out for him this week. 

Rams (-2.5) at Cardinals

  • Rams: TE Gerald Everett (knee), OT Rob Havenstein (knee), DB Darious Williams (ankle) OUT
  • Cardinals: QB Kyler Murray (hamstring), DL Jonathan Bullard (foot) QUESTIONABLE

Everett and Williams did not practice all week, while Havenstein came back as a limited participant on Thursday and Friday. Still, it was not enough, as he has already been ruled out for Sunday's matchup. Running back Todd Gurley did not practice on Friday, but the Rams said it was not related to injury. 

Murray was a full participant in practice all week, but apparently pulled his hamstring at some point. He's listed as questionable. Linebacker Terrell Suggs missed practice twice this week, but it was not related to any kind of injury according to the team. 

Raiders at Chiefs (-10)

Renfrow broke a rib and punctured his lung in last week's loss to the Jets. It's possible that he misses the rest of his rookie season. Brown was a full participant in practice on Wednesday and Thursday, but was held out on Friday due to a knee injury. While safety Lamarcus Joyner was limited in practice all week, he's good to go on Sunday against the Chiefs. 

Williams did not practice all week after sustaining a rib injury against the Chargers in Mexico City. He will not play this Sunday. The Chiefs have some good news entering Week 13, however, as Tyreek Hill was a full participant in practice all week after injuring his hamstring against the Chargers. The Chiefs should also have cornerback Kendall Fuller (right thumb) back for the first time since Week 6. 

Chargers (-3) at Broncos

  • Chargers: OT Russell Okung (groin), OT Sam Tevi (knee), WR Geremy Davis (hamstring) QUESTIONABLE
  • Broncos: LB Von Miller (knee), LB Alexander Johnson (knee), LB Josey Jewell (ankle), NT Shelby Harris (ankle), DB Duke Dawson (concussion), OT Ja'Wuan James (knee) QUESTIONABLE

Okung was a full participant in practice on Friday after being limited earlier this week. Tevi was limited all week, so his status appears to be more in doubt that Okung's. 

According to Aric DiLalla of the Broncos' official website, head coach Vic Fangio says that Miller and Johnson are "truly 50-50" to play against the Chargers. Both were limited participants in practice on Friday, along with Dawson and Harris. 

Patriots (-3.5) at Texans

  • Patriots: CB Jason McCourty (groin), TE Ryan Izzo (illness), DL Byron Cowart (head) OUT; S Patrick Chung (illness, heel, chest), LB Jamie Collins (illness), OL Jermaine Eluemunor (illness), CB Stephon Gilmore (illness), LB Dont'a Hightower (illness), CB Joejuan Williams (illness), OL Isaiah Wynn (illness) OL Marcus Cannon (illness), LB Ja'Whaun Bentley (knee), WR Phillip Dorsett (concussion), DB Nate Ebner (ankle, back), WR Julian Edelman (shoulder), WR Mohamed Sanu (ankle), WR Matthew Slater (hamstring), LB Kyle Van Noy (illness) QUESTIONABLE
  • Texans: DE Carlos Watkins (hamstring) OUT; OL Tytus Howard (knee) DOUBTFUL; DE Angelo Blackson (shoulder), CB Gareon Conley (hip), LB Brennan Scarlett (shoulder) QUESTIONABLE

As you can tell, some kind of bug has gone around the Patriots' locker room, as 10 different players are listed as questionable or out for New England's big matchup with Houston due to an illness. Most of those names are starters as well. Apart from the illness, Edelman was limited in practice all week due to a shoulder injury, Jason McCourty was limited all week with a groin injury and Sanu was limited all week with an ankle injury. It could be tough sledding for the Patriots this week against the Texans. 

For the Texans, the biggest development was that wide receiver Will Fuller was a a full participant in practice on Friday. He had been hampered by a hamstring injury, even though he put up 140 yards on the Colts last week. Howard, Blackson, Conley and Scarlett were limited participants in practice all week long. 

Vikings at Seahawks (-3)

  • Vikings: LB Ben Gedeon (concussion) OUT; WR Adam Thielen (hamstring), DT Linval Joseph (knee), DT Shamar Stephen (knee), S Harrison Smith (hamstring), S Anthony Harris (groin) QUESTIONABLE
  • Seahawks: FB Nick Bellore (quad), CB Neiko Thorpe (groin) DOUBTFUL; TE Luke Willson (hamstring), DT Jarran Reed (ankle), DT Al Woods (ankle), DE Jadeveon Clowney (core), LB Mychal Kendricks (hamstring) QUESTIONABLE

Thielen hasn't taken the field since Nov. 3, when he exited early against the Kansas City Chiefs, but he's optimistic he'll be ready to go in Seattle after practicing in limited fashion on Saturday. The Seahawks would potentially be a solid matchup for his return, as they're allowing the fourth most passing yards per game. Harris was also a limited participant, while Joseph, Stephen and Smith were all full go on Saturday, indicating they're more likely to take the field.

Seattle, meanwhile, could be somewhat depleted in its front seven if Clowney, Reed and Kendricks are unable to suit up. Tyler Lockett is good to go after missing time in practice this week.