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White Sox starter Lance Lynn makes his 2022 debut when he takes the mound on Monday against the Detroit Tigers at Comerica Park in Detroit. The 35-year-old Lynn, who went 11-6 with a 2.69 ERA over 28 starts last year, had right knee surgery during spring training and has yet to pitch this season. He is set to face Rony Garcia (0-1, 4.50 ERA). Chicago is a -135 favorite (risk $135 to win $100) in the latest MLB odds from Caesars Sportsbook while Detroit is a +115 underdog. First pitch is set for 7:10 p.m. ET. 

The game is one of 10 on the MLB schedule for Monday. Elsewhere in the majors, the Braves (-145) will try to stretch their winning streak to 12 games as they take on the Nationals, and the Cubs (+110) will try to break a season-high six-game losing streak as they take on the Padres. Before making any MLB picks or parlays, be sure to check out the MLB predictions and betting advice from SportsLine's proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It's on a 55-42 roll on top-rated MLB money-line picks through 10 weeks, returning more than $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in four confident MLB best bets for Monday. They all involve games at 7:05 p.m. ET or later, so there's still time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of well over 11-1. You can see the model's MLB picks for Monday only at SportsLine

Top MLB picks today

The model, which simulated every game on Monday schedule 10,000 times, is high on Marlins (+115) against the Phillies in a 7:05 p.m. ET start (see tickets on StubHub). 

The Marlins enter the game on a bit of a roll. They've won five of their last six games with the only loss coming on Sunday to the AL West-leading Astros and Justin Verlander. They've also won the last six games that Sandy Alcantara (6-2, 1.61 ERA) has started.

In addition, Miami has dominated the recent series against the Phillies. The Marlins have won five of the last six meetings between the teams. The last time Miami faced Philadelphia starter Aaron Nola, the Marlins roughed up Nola for seven runs on nine hits, including two home runs, in an 11-6 victory last season. 

Featured Game | Philadelphia Phillies vs. Miami Marlins

How to make MLB picks and parlays for Monday

The model also locked in three other best bets for Monday, including a play on a big National League underdog. You can see the model's MLB Monday best bets and parlay only at SportsLine.

What MLB picks should you target for a payout of well over 11-1? And what big underdog does the model like on Monday? Visit SportsLine now to see the MLB best bets from an advanced model that is on a 55-42 roll on top-rated MLB money-line picks through 10 weeks, and find out.