The Los Angeles Rams can join the Arizona Cardinals and Green Bay Packers atop the NFC with a win on Monday Night Football over the San Francisco 49ers. By virtue of the Cardinals (8-2) losing to the Panthers and the Packers (8-2) beating the Seahawks on Sunday, the Rams (7-2) can forge a three-way tie atop the conference. Finishing as the best team in the NFC is particularly important since only the top seed will receive a first-round bye. The 49ers (3-5) sit at the bottom of the NFC West.

Kickoff from Levi's Stadium is set for 8:15 p.m. ET. Los Angeles is favored by 3.5 points in the latest 49ers vs. Rams odds from Caesars Sportsbook, while the Over-Under is 50.5. Before locking in your Rams vs. 49ers picks, make sure you check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,600 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 10 of the 2021 season on an incredible 128-88 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up!

Now, the model has simulated Rams vs. 49ers 10,000 times and just revealed its coveted NFL picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for 49ers vs. Rams:

  • 49ers vs. Rams spread: Rams -3.5
  • 49ers vs. Rams over-under: 50.5 points 
  • 49ers vs. Rams money line: LAR -190, SF +160 
  • LAR: Under has hit in three of Rams' last five games
  • SF: 49ers are 13-4 against the spread in their last 17 Monday games
Featured Game | San Francisco 49ers vs. Los Angeles Rams

Why the Rams can cover

Rams running back Darrell Henderson ranks in the top 10 in multiple categories this season. Henderson is eighth in carries (121), seventh in rushing yards (562), and fifth in rushing touchdowns (five). The Memphis product has rushed for 70-plus yards in five of the nine games he's played in.

Henderson has eclipsed more than 100 scrimmage yards in two games. Against the Arizona Cardinals, he had 14 carries for 89 yards added another 27 yards through the air. Two weeks later against the New York Giants, Henderson had 21 carries for 78 yards and a rushing score. The 2019 third-round pick also snagged three passes for 29 yards and another touchdown.

Why the 49ers can cover

Deebo Samuel is off to the fastest start among receivers in franchise history. The 25-year-old receiver from South Carolina ranks second in the NFL in total receiving yards (882). The 882 yards are the most by a San Francisco receiver in the first eight games of a season in franchise history, eclipsing the 869 Jerry Rice had in 1989.

In addition, 49ers edge rusher Nick Bosa has been very strong so far this season. After missing most of last year with an ACL tear, Bosa has a pressure percentage of 13.4, which ranks 11th among edge rushers with at least 200 snaps as a pass-rusher. He also has seven sacks despite facing the highest double-team rate of any edge rusher in the NFL.

How to make Rams vs. 49ers picks 

SportsLine's model is leaning under on the total, projecting the teams to combine for 48 points. The model also says one side of the spread hits in over 50 percent of simulations. You can only see the model's Rams vs. 49ers picks at SportsLine. 

So who wins Rams vs. 49ers on Monday Night Football? And which side of the spread hits in over 50 percent of simulations? Visit SportsLine now to see which side of the Rams vs. 49ers spread to jump on, all from the advanced model that is up over $7,600 on its NFL picks, and find out.