The San Francisco 49ers put their four-game winning streak on the line when they host the Miami Dolphins in a key Week 13 NFL game on Sunday at Levi's Stadium in Santa Clara, Calif. After starting the season 3-4, the 49ers (7-4) have beaten the Rams, Chargers, Cardinals and Saints and lead the NFC West by one game over Seattle. San Francisco hasn't won five in a row since starting the 2019 season 8-0. Meanwhile, the Dolphins (8-3) have won five consecutive games and sit in second place in the AFC East, a half-game behind Buffalo (9-3). 

Kickoff is set for 4:05 p.m. ET. San Francisco is a 5-point favorite in the latest 49ers vs. Dolphins odds from Caesars Sportsbook while the over/under for total points scored is 45.5. Before you make any Dolphins vs. 49ers picks, you need to see the NFL predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 13 of the 2022 NFL season on an incredible 155-110 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has zeroed in on 49ers vs. Dolphins and locked in its picks and NFL Week 13 predictions. You can only see the model's picks at SportsLine. Now, here are several NFL odds and betting lines for Dolphins vs. 49ers:

  • 49ers vs. Dolphins spread: San Francisco -5
  • 49ers vs. Dolphins over/under: 45.5 points 
  • 49ers vs. Dolphins money line: San Francisco -235, Miami +192
  • SF: 49ers lead the league in run defense (79.5 yards per game) 
  • MIA: Tua Tagovailoa leads the league in passer rating (115.7) 
  • 49ers vs. Dolphins picks: See picks here
Featured Game | San Francisco 49ers vs. Miami Dolphins

Why the 49ers can cover

Nick Bosa is having another impact season off the edge. The No. 2 pick in the 2019 NFL Draft, Bosa leads the league in quarterback hits with 30, six more than any other player. He also ranks third in the league in sacks (11.5) and has a sack in five straight games.

Bosa could be facing a Miami team without both of its starting offensive tackles. Right tackle Austin Jackson is out with an ankle injury. Left tackle Terron Armstead is listed as doubtful because of a pectoral strain he suffered last week against Houston. See which team to pick here.

Why the Dolphins can cover

Quarterback Tua Tagovailoa is on a roll. Over his last five games, the 6-foot, 217-pound southpaw has thrown 11 touchdowns against zero interceptions and has a passer rating of 119.7. Miami won those five games by an average score of 30-20.

In addition, the Dolphins have arguably the league's best receiver in Tyreek Hill. The game-breaking wideout leads the NFL in receiving yards per game (112.1) and ranks second in receptions (87), just four behind Stefon Diggs, who played on Thursday night. Hill has 21 catches of 20-plus yards this season, which is tied for the most in the league with the Vikings' Justin JeffersonSee which team to pick here.

How to make 49ers vs. Dolphins picks

Now, the model has broken down Dolphins vs. 49ers from every angle. The model is leaning Under on the point total, but it says one side of the spread cashes in well over 50% of simulations. You can see who it is, and get the rest of the model's NFL picks and analysis, at SportsLine.

So who wins Dolphins vs. 49ers? And which team covers well over 50% of the time? Visit SportsLine now to see which side of the Dolphins vs. 49ers spread you should jump on, all from the advanced model that is up well over $7,000, and find out.