Two of the better teams in the National League collide when the San Diego Padres host the New York Mets in the second game of a four-game series on Friday at Petco Park in San Diego. The Mets (27-22) hold a 3.5-game lead over the Braves in the NL East. Meanwhile, the Padres (35-23) sit in second place in the loaded NL West, one game behind the division-leading Giants. The Padres are -180 money-line favorites in the latest Padres vs. Mets odds from William Hill Sportsbook, while the Mets are +165 underdogs. The over-under for total runs scored is seven. 

The game is one of 15 on Friday's MLB schedule. Other matchups include the Giants and Cubs playing the second game of their four-game series in San Francisco and the Yankees and Red Sox meeting in the Bronx. Before making any MLB picks on those games or others in the evening, you need to see the MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 71-52 on top-rated MLB money-line picks through nine weeks, returning over $800. Anyone following it has seen huge rewards.

Now, the model has evaluated the latest MLB lines for Friday and posted its best bets for the evening games. Parlaying these four MLB picks would pay over 13-1. Head to SportsLine to see the picks

Top MLB picks for Friday, June 4

The model is high on the Marlins (-105) beating the Pirates at 7:05 p.m. ET. The teams met on Thursday with the Pirates rallying past the Marlins, 5-3. The loss was Miami's sixth straight.

But on Friday the Marlins face up-and-down Pittsburgh starter Mitch Keller (3-6, 6.54 ERA). The 25-year-old righty has not been able to string together two consecutive quality starts this season, and he's coming off a strong one: five scoreless innings against the Rockies on Saturday. 

Featured Game | Pittsburgh Pirates vs. Miami Marlins

How to make MLB predictions, parlays for Friday, June 4

The model has locked in three other MLB best bets, including one on a surprising underdog in the American League. You can see the best bets only at SportsLine.

So which MLB picks should you make on Friday for a shot at a big return of over 13-1? And which surprising underdog do you need to be all over? Visit SportsLine now to see Friday's top MLB picks, all from the projection model off to a fast start in 2021.