Saint Peter's opened the 2022 NCAA Tournament bracket with a first round upset over No. 2 seed Kentucky. The Peacocks have continued battling to a 2022 March Madness Sweet 16 game against No. 3 seed Purdue. In the West region, No. 4 seed Arkansas will try to survive against a Gonzaga team that is a perpetual Final Four contender. Caesars Sportsbook lists the Boilermakers as 12.5-point favorites over the Peacocks in the latest 2022 NCAA Tournament odds, while the Razorbacks and Bulldogs are separated by a nine-point line.

The Peacocks hadn't played a ranked team all year prior to March Madness 2022, but they'll now face their third in as many games. Purdue is 18-2 overall this season as a double-digit favorite, but just 9-11 against the spread. All of the 2022 NCAA Tournament lines for the March Madness Sweet 16 are listed below, and SportsLine's advanced computer model has all the college basketball betting advice and predictions you need to make the best Sweet 16 picks now.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen huge returns.

The model absolutely crushed its March Madness picks last tournament, beating over 92 percent of all CBS Sports brackets for the second time in three years. The model also nailed a whopping three teams in the Final Four last year. 

Now, it has turned its attention to the latest 2022 NCAA Tournament odds and locked in picks for every Sweet 16 matchup. Head to SportsLine now to see every pick.

Top 2022 NCAA Tournament Sweet 16 predictions

One of the model's strongest Sweet 16 picks is that Gonzaga (-8.5) covers the spread against Arkansas. The No. 1 overall seed in the NCAA Tournament 2022 bracket survived early scares in the first two rounds, allowing No. 16 seed Georgia State to hang around into the second half and needing to overcome a 12-point deficit to beat No. 9 seed Memphis.

Eric Musselman's Arkansas squad generally likes to play fast, which will play right into Gonzaga's hands. The Bulldogs rank sixth in the nation in adjusted tempo (72.4) and first in adjusted offensive efficiency (122.1), points per game (87.7) and field-goal shooting percentage (52.6). After a week to recover from a pair of slow starts, the model likes Gonzaga to come out of the gates strong and cover the spread in 70 percent of simulations.

Another one of its 2022 NCAA Tournament predictions: The Miami Hurricanes (-2.5) cover against the Iowa State Cyclones. Both teams have advanced with multiple March Madness upsets, but the Hurricanes are favored despite Iowa State winning all three games it has played as an underdog between two and three points this season. After a no-show in the ACC tournament against Duke, Isaiah Wong has been the Canes' top player in the NCAA Tournament 2022 with 22 points against USC and 21 against Auburn.

Iowa State won its first game against an LSU program that fired its head coach just days before the start of the big dance. It then beat a Wisconsin team that hadn't been the same since a March 1 win over Purdue. The Hurricanes only hit 3-of-15 three-pointers, but still shot 48.5 percent from the field to beat the Tigers and should come into their Sweet 16 matchup feeling strong about their chances. Miami has had an average scoring margin of plus-5.3 points over their last three games, while Iowa State's has been minus-7. SportsLine's model projects the Hurricanes cover in well over 50 percent of simulations.

How to make 2022 NCAA Tournament picks

The model has also made the call on who will win and cover every other Sweet 16 matchup and has identified a No. 1 seed that goes down hard. It also says an underdog wins outright well over 60 percent of the time. You can only get every pick for every game at SportsLine.

So which NCAA Tournament picks can you make with confidence, and which underdog is a must-back? Check out the latest Sweet 16 odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has crushed its college basketball picks, and find out.

NCAA Tournament Sweet 16 odds, spreads, lines

Gonzaga vs. Arkansas (+8.5, 154.5)
Michigan vs. Villanova (-5, 135)
Texas Tech vs. Duke (+1, 136.5)
Houston vs. Arizona (-2, 145)
Saint Peter's vs. Purdue (-12.5, 135.5)
Providence vs. Kansas (-7.5, 141.5)
North Carolina vs. UCLA (-2, 142)
Iowa State vs. Miami (-2.5, 133)