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The New Orleans Saints needed a win last week and found it at home against the Los Angeles Rams. This week, the Saints are one of the biggest NFL underdogs in the Week 12 NFL odds at Caesars Sportsbook and face another California team, San Francisco (-8.5). Meanwhile, life became even worse for the Rams, who are 15.5-point underdogs against the Chiefs and will be without starting quarterback Matthew Stafford (concussion). All three Florida teams are back in action after byes last week, with Miami (-14) returning as the biggest favorite among them against Houston in the NFL spreads. All of the Week 12 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 12 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 12 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 12 NFL predictions

One of the model's strongest Week 12 NFL picks is that the Seahawks (-4) cover the spread at home against the Raiders. Seattle comes back from its bye following its 21-16 loss to Tampa Bay in Germany, but the Seahawks should be confident with a 3-1 home record this season. The Seahawks' last home game was a 27-13 win over the Giants.

Las Vegas notched just its third win of the season last week, but needed overtime to do it against an equally-troubled Denver Broncos side in Week 11. This season, the Raiders have given up the ninth-most passing yards and eighth-fewest rushing yards on offense. Meanwhile, Geno Smith has the seventh-most passing yards among all quarterbacks (2,474) and the sixth-most touchdown passes (17), with just four interceptions.

The model projects that Smith will throw for over 250 yards with two touchdowns. His steadiness is enough for Seattle to cover in over 60% of simulations. See which other teams to pick here.

Top Week 12 NFL survivor picks

The model's Week 12 NFL knockout pool picks say to avoid the Broncos, even though they are favorites over the Panthers. Carolina is turning to Sam Darnold under center and hasn't gotten a TD pass from a starting quarterback since Week 8. He will make his season debut against a team whose offense is unequivocally the worst in the NFL, as Denver is averaging the fewest points (14.7).

The Broncos have not won a game in an opponent's stadium all season, going 0-4 in true road contests. All three of Carolina's wins have come at home, where it has a positive point differential, a positive turnover differential and has won its last two games, both by double-digits. Denver just cut leading rusher Melvin Gordon, while wide receiver Jerry Jeudy (ankle) is unlikely to play, further hampering the Broncos' struggling offense. The model foresees another dispirited showing by Denver's offense, and it advises you to look elsewhere with Week 12 NFL knockout pool picks. See which team you should pick here.

Top Week 12 NFL office pool picks

One of the strongest Week 12 NFL football pool picks from the model is that the Buccaneers beat the Browns. Tampa may have found the solution to its run game in its last game, as the team rushed for a season-high 161 yards. Rookie Rachaad White carried the rock 22 times for 105 yards, which was nearly as many yards as he had in his first eight games combined (117). He got the start over Leonard Fournette, and the veteran still had a productive day in a reserve role with 57 yards and a score.

With White's emergence making the ground games of these two teams a closer to even, Tampa has the offensive edge. The Bucs are projected to score their second-most points of the season, and Tampa is forecasted to win in 60% of simulations. See which other teams to pick here.

How to make Week 12 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 12 NFL schedule, and it also says a Super Bowl contender goes down hard. It's also backing a shocking team in its NFL survivor picks. You can only get every pick for every game at SportsLine.

So what NFL predictions, NFL pool picks, and NFL survivor picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000 since its inception, and find out.

Week 12 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Nov. 27

Broncos at Panthers (+1, 36)

Featured Game | Carolina Panthers vs. Denver Broncos

Buccaneers at Browns (+3.5, 42.5)

Featured Game | Cleveland Browns vs. Tampa Bay Buccaneers

Ravens at Jaguars (+3.5, 43.5)

Featured Game | Jacksonville Jaguars vs. Baltimore Ravens

Texans at Dolphins (-14, 47)

Featured Game | Miami Dolphins vs. Houston Texans

Bears at Jets (-6, 38.5)

Featured Game | New York Jets vs. Chicago Bears

Bengals at Titans (+2.5, 43.5)

Featured Game | Tennessee Titans vs. Cincinnati Bengals

Falcons at Commanders (-4, 40.5)

Featured Game | Washington Commanders vs. Atlanta Falcons

Chargers at Cardinals (+3, 48.5)

Featured Game | Arizona Cardinals vs. Los Angeles Chargers

Raiders at Seahawks (-4, 47.5)

Featured Game | Seattle Seahawks vs. Las Vegas Raiders

Rams at Chiefs (-15.5, 42)

Featured Game | Kansas City Chiefs vs. Los Angeles Rams

Saints at 49ers (-9.5, 43)

Featured Game | San Francisco 49ers vs. New Orleans Saints

Packers at Eagles (-6.5, 46.5)

Featured Game | Philadelphia Eagles vs. Green Bay Packers

Monday, Nov. 28

Steelers at Colts (-2.5, 39)

Featured Game | Indianapolis Colts vs. Pittsburgh Steelers