Each week, I will use this space to tell you what I think are a few of the best bets heading into the weekend. I will also throw in an upset of the week, which will be a team that is at least a touchdown underdog that I am picking to win outright.
Week 1 Picks
Alabama vs. Florida State (+7): For the sixth consecutive season, Alabama will play its season opener on a neutral field against a top opponent. The Crimson Tide won the previous five by double digits. If any team is equipped to put a stop to that streak, it is Florida State, which is easily the best team Alabama will have faced in these opening week kickoff games. The loser of this game still has a legitimate chance to play in the College Football Playoff, but I can't bring myself to go against Nick Saban's track record. It'll be closer than last year's win over USC (we all hope), but Bama will get the job done again. Pick: Alabama (-7).
Ohio State at Indiana (+21): When these two last faced each other, Kevin Wilson was the head coach at Indiana and the Hoosiers were giving the Buckeyes fits before fading. Indiana played the Buckeyes reasonably tough each of the past three seasons. Now, Wilson is running the Ohio State offense, so look for the Buckeyes to have a better flow on that side of the ball this year and for J.T. Barrett to have a bounce-back season. Indiana figures to be more of a defensive-oriented team than in years past, but Ohio State has one of the best front sevens in the country. There is a lot of hype for this game, but it will likely disappoint. Pick: Ohio State (-21).
Navy at Florida Atlantic (+9.5): Lane Kiffin will be looking to make something of a splash in his FAU debut against a Navy squad that has averaged nine wins over the past five years. The Owls figure to be better offensively this season, although maybe not right off the bat. There is no reason to expect the Owls to be able to handle Navy's offense though. Pick: Navy (-9.5).
Upset of the Week
Wyoming at Iowa (-11.5): If Wyoming quarterback Josh Allen is the NFL prospect everyone seems to think he is, Iowa better watch out. The Cowboys will get their points against the Hawkeyes and will likely be able to stifle the Iowa passing game. Wyoming has the best secondary in the Mountain West and the Hawkeyes are breaking in a new QB The key for the Cowboys will be stopping the run and making Iowa try to beat them in the air. That is not as easy as it sounds. Pick: Wyoming (+11).
Other CFP candidates in action
Western Michigan at USC (-26.5) Pick: USC
For picks from every Top 25 game from the CBS Sports staff, check out our Expert Picks page.