There are already multiple teams eliminated from the NFL playoff picture in both conferences, but there is still plenty of value in the latest NFL spreads. Jacksonville travels to New York in a battle of rookie quarterbacks on Sunday. The game is a pick'em in the latest Week 16 NFL odds at Caesars Sportsbook. Jacksonville currently holds the spot for the No. 1 pick in the upcoming draft, while the Jets are No. 4.

It is important to factor motivation into your thought process when handicapping the Week 16 NFL Vegas lines. All of the Week 16 NFL lines are listed below and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 16 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 16 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 16 NFL predictions

One of the model's strongest Week 16 NFL picks is that the Raiders (PK) cover the spread against the Broncos. Both teams are 7-7 entering Week 16 and on the periphery of a crowded AFC playoff picture. However, Las Vegas will have the advantage of playing at home, while Denver might be without starting quarterback Teddy Bridgewater (concussion). The Raiders will also have a 34-24 victory on the road against the Broncos in Week 6 to draw from in which Derek Carr threw for 341 yards and two touchdowns.

Denver was a five-point favorite in that game and is 1-3 against the spread in its last four road games. The model is predicting that Carr throws for nearly 300 yards and multiple scores again. That helps Las Vegas cover in nearly 60 percent of simulations, while the over also hits nearly 60 percent of the time.

Another one of the model's Week 16 NFL predictions: The Texans (+10.5) cover at home against the Chargers. The Texans might be eliminated from playoff contention, but they did not let that play a role in their performance last week. They took a 14-3 lead and never looked back in a 30-16 win over Jacksonville. Rookie quarterback Davis Mills has shown improvement, passing for 550 combined yards and three touchdowns over his last two games.

Mills' confidence paid off last week, when he was able to notch his first career win in the NFL. Los Angeles comes into Sunday's game dealing with plenty of pressure following an overtime loss to Kansas City last week. The Chargers are now clinging to a playoff spot in the AFC with games against two divisional opponents on tap in the next two weeks.

SportsLine's model expects that pressure to result in an interception from Los Angeles quarterback Justin Herbert, which greatly decreases his chances of covering as a large favorite. The Texans cover the spread in over 50 percent simulations. 

How to make Week 16 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 16 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So which NFL picks can you make with confidence, and which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,000 since its inception, and find out.

Week 16 NFL odds, spreads, lines

Sunday, Dec. 26

Buccaneers at Panthers (+10, 42.5)

Featured Game | Carolina Panthers vs. Tampa Bay Buccaneers

Giants at Eagles (-10, 40.5)

Featured Game | Philadelphia Eagles vs. New York Giants

Chargers at Texans (+10.5, 46)

Featured Game | Houston Texans vs. Los Angeles Chargers

Lions at Falcons (-5.5, 43)

Featured Game | Atlanta Falcons vs. Detroit Lions

Ravens at Bengals (-3, 45)

Featured Game | Cincinnati Bengals vs. Baltimore Ravens

Rams at Vikings (+3.5, 49)

Featured Game | Minnesota Vikings vs. Los Angeles Rams

Jaguars at Jets (PK, 41.5)

Featured Game | New York Jets vs. Jacksonville Jaguars

Bills at Patriots (-2, 43.5)

Featured Game | New England Patriots vs. Buffalo Bills

Bears at Seahawks (-6.5, 42.5)

Featured Game | Seattle Seahawks vs. Chicago Bears

Steelers at Chiefs (-8.5, 45)

Featured Game | Kansas City Chiefs vs. Pittsburgh Steelers

Broncos at Raiders (PK, 41)

Featured Game | Las Vegas Raiders vs. Denver Broncos

Washington Football Team at Cowboys (-10.5, 47)

Featured Game | Dallas Cowboys vs. Washington Commanders

Monday, Dec. 27

Dolphins at Saints (+1.5, 37.5)

Featured Game | New Orleans Saints vs. Miami Dolphins