NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

Underdogs made some noise last week in college football as the Indiana Hoosiers went on the road and shocked the Wisconsin Badgers. The Hoosiers were 14-point underdogs but earned an impressive 14-6 victory with backup QB Jack Tuttle under center. Coastal Carolina also pulled off an upset as a double-digit underdog against the visiting BYU Cougars. In Conference USA, Marshall closed as a 23.5-point favorite over Rice, but the Thundering Herd fell flat in a 20-0 loss.

This week Michigan State is a 14.5-point underdog in the Week 15 college football odds from William Hill Sportsbook against Penn State, a team the Spartans have beaten in five of their last seven meetings. Can the Spartans pull off the upset on the road, or should you look elsewhere for your college football bets? Before locking in any Week 15 college football picks on that game or others, be sure to see the latest college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It is a sizzling 50-31 on all top-rated picks through 14 weeks of the 2020 college football season, returning almost $700 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 15 from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 15 college football predictions 

One of the top Week 15 college football picks the model is recommending: No. 10 Miami (FL) (-3) covers at home against North Carolina in a 3:30 p.m. ET kickoff on Saturday. The one-loss Hurricanes still have an outside shot at the College Football Playoff, but they'll need to win convincingly in this one to remain in that conversation. They've won and covered in two straight, including as 14.5-point favorites over Duke in an impressive 48-0 blowout in their last outing.

UNC, meanwhile, has put up big offensive numbers but has struggled defensively. The Tar Heels are also just 1-3 ATS in their last four games. Miami quarterback D'Eriq King throws for almost 300 yards and three touchdowns in the simulations as the Hurricanes cover in well over 60 percent of simulations. The under (67.5), meanwhile, hits almost 60 percent of the time.

Another one of the top Week 15 college football predictions from the model: Auburn (-6.5) gets the win and cover against the Mississippi State Bulldogs in a SEC West showdown at 7:30 p.m. ET on Saturday. The Tigers have dominated this series over the years, winning 14 of their last 19 matchups against the Bulldogs.

Auburn's Bo Nix is a dual-threat quarterback who continues to disrupt defensive game plans with his running ability. In fact, Nix enters Saturday's matchup having scored a rushing touchdown in four of his last five games. He averaged 4.5 yards per carry last week against Texas A&M and scored two rushing touchdowns in Auburn's 31-20 loss.

Mississippi State, meanwhile, limps into the contest having lost six of its last seven games. The Bulldogs are averaging just 18.3 points per game this season, which doesn't bode well for Mississippi State on Saturday. Nix is projected to account for well over 250 total yards and two touchdowns in the simulations, while no MSU receiver tops 50 receiving yards as the Tigers cover the spread in nearly 70 percent of simulations.

How to make Week 15 college football picks 

The model has also made the call on who wins and covers in every other Week 15 FBS matchup, and it is calling for an upset in the ACC in a game where the line is way off. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 15? And which underdog should you be all over? Check out the latest Week 15 college football odds for some of the week's most notable games below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $3,500 in profit over the past four-plus seasons, and find out.

Week 15 college football odds (via William Hill)

Saturday, Dec. 12

Alabama vs. Arkansas (+32)

Latest Odds: Arkansas Razorbacks +32

Utah vs. Colorado (+1)

Latest Odds: Colorado Buffaloes -2.5

LSU vs. Florida (-24)

Latest Odds: Florida Gators -23.5

Coastal Carolina vs. Troy (+13.5)

Latest Odds: Troy Trojans +13.5

Wake Forest vs. Louisville (-2.5)

Latest Odds: Louisville Cardinals +1

Navy vs. Army (-6.5)

Latest Odds: Army West Point Black Knights -7

Wisconsin vs. Iowa (-1.5)

Latest Odds: Iowa Hawkeyes +2

North Carolina vs. Miami (FL) (-3.5)

Latest Odds: Miami (FL) Hurricanes -3

Auburn vs. Mississippi State (+6.5)

Latest Odds: Mississippi State Bulldogs +5.5

San Diego State vs. BYU (-14.5)

Latest Odds: BYU Cougars -17.5

UNLV vs. Hawaii (-21)

Latest Odds: Hawaii Rainbow Warriors -19