There are only six teams in the NFL with 2-0 records, but perhaps the most surprising is the New York Giants. The Giants didn't have a winning record at any point from 2017 to 2021, but have won their first two games of the season over the Titans and Panthers. Now, they're listed as one-point home favorites in the Week 3 NFL odds from Caesars Sportsbook as they take on the Dak Prescott-less Cowboys on Monday Night Football. The Dolphins have also been a surprise 2-0 team, especially when you consider they trailed the Ravens 28-7 at one point in Week 2. However, they'll face a much stiffer challenge, with the Bills favored by 4.5 according to the latest Week 3 NFL spreads. All of the Week 3 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 3 NFL picks now

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 3 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 3 NFL predictions

One of the model's strongest Week 3 NFL picks is that the Bengals (-6.5) go on the road and cover against the Jets. The defending AFC champions are once again struggling in pass protection. The offensive line allowed Joe Burrow to be sacked a league-leading 51 times in 2021 and the third-year quarterback has already gone down 13 times over the first two weeks of the 2022 NFL season.

However, Cincinnati is hopeful that it can right the ship against a Jets squad that hasn't produced much pressure so far this year. The Jets only have three sacks and nine quarterback hits in the first two games, and Burrow is still dangerous when he has time considering the weapons at his disposal. The model expects that to happen this week, with Burrow throwing for nearly 300 yards and two scores to help the Bengals cover in over 50 percent of simulations.

Another one of the model's Week 3 NFL predictions: The Seahawks (-1) cover the spread at home versus the Falcons. No matter which uniform he's worn, Geno Smith has performed much better in home games than on the road. He has a 12-11 straight-up career home record versus 8-16 in away games, and Smith has covered in his last six home starts. Smith is off to an efficient start this year, leading the NFL with an 81% completion percentage, while Atlanta allows the fourth-highest completion percentage at 71.4.

The Falcons are projected to average just 3.9 yards per carry, compared to Seattle having a 5.5 rushing average. Considering the game manager roles of these two QBs, Smith has an advantage, which is why the model is behind the Seahawks to cover. See which other teams to pick here.

How to make Week 3 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 3 NFL schedule, and it's calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,000 since its inception, and find out.

Week 3 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Sunday, Sept. 25

Chiefs at Colts (+5, 51)

Featured Game | Indianapolis Colts vs. Kansas City Chiefs

Ravens at Patriots (+2.5, 44.5)

Featured Game | New England Patriots vs. Baltimore Ravens

Saints at Panthers (+2, 41)

Featured Game | Carolina Panthers vs. New Orleans Saints

Texans at Bears (-3, 39.5)

Featured Game | Chicago Bears vs. Houston Texans

Bills at Dolphins (+4.5, 54.5)

Featured Game | Miami Dolphins vs. Buffalo Bills

Lions at Vikings (-6.5, 52)

Featured Game | Minnesota Vikings vs. Detroit Lions

Bengals at Jets (+6.5, 46)

Featured Game | New York Jets vs. Cincinnati Bengals

Raiders at Titans (+2, 45.5)

Featured Game | Tennessee Titans vs. Las Vegas Raiders

Eagles at Commanders (+6, 47.5)

Featured Game | Washington Commanders vs. Philadelphia Eagles

Jaguars at Chargers (-3.5, 42.5)

Featured Game | Los Angeles Chargers vs. Jacksonville Jaguars

Packers at Buccaneers (-1.5, 42)

Featured Game | Tampa Bay Buccaneers vs. Green Bay Packers

Rams at Cardinals (+3.5, 48.5)

Featured Game | Arizona Cardinals vs. Los Angeles Rams

Falcons at Seahawks (-1, 43.5)

Featured Game | Seattle Seahawks vs. Atlanta Falcons

49ers at Broncos (+1.5, 44.5)

Featured Game | Denver Broncos vs. San Francisco 49ers

Monday, Sept. 26

Cowboys at Giants (-1, 39)

Featured Game | New York Giants vs. Dallas Cowboys