The New Orleans Saints have rebounded from a lackluster 1-2 start, reeling off eight straight wins and taking command of the NFC South heading into a Week 13 matchup against the Falcons. The Saints will be without future Hall of Fame quarterback Drew Brees while he recovers from multiple broken ribs, and will instead go with multi-purpose QB Taysom Hill for the second straight week. The Saints are favored by a field goal in the latest Week 13 NFL odds from William Hill Sportsbook, one of the smallest NFL spreads of the week.

On Sunday Night Football, Patrick Mahomes and the Kansas City Chiefs are favored by 13.5, one of the largest NFL Vegas lines we'll see all season. Should you back the Denver Broncos, whose quarterback stable will return this week after sitting out last week's loss due to COVID-19 protocols, in your NFL bets? All of the Week 13 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and predictions you need to make the best Week 13 NFL picks now.

The SportsLine Projection Model simulates every NFL game 10,000 times and is up over $7,900 for $100 players on its top-rated NFL picks since its inception five-plus years ago.

It's a sizzling 20-10 on top-rated NFL picks this season, already returning almost $900. The model enters Week 13 on an incredible 116-75 roll on top-rated NFL picks that dates back to the 2017 season. Additionally, the model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.

Now, it has examined the latest Week 13 NFL odds and NFL betting lines from William Hill, simulated every snap, and its predictions are in. Head to SportsLine now to see them all.

Top NFL predictions for Week 13

One of the top Week 13 NFL picks the model recommends: The Packers (-9) cover as home favorites against the Philadelphia Eagles. The Packers are coming off a dominant performance against the Bears on Sunday Night Football in Week 12 and now hold a three-game lead in the NFC North. 

After losing the turnover battle in three of their previous four games, the Packers forced three turnovers without giving the ball away against Chicago. Meanwhile, the Eagles have converted on just 38.6 percent of third downs and 31.8 percent of fourth downs (29th) and struggle to keep drives alive. SportsLine's model predicts that Packers quarterback Aaron Rodgers will throw for nearly 300 yards and two touchdowns as Green Bay covers in well over 50 percent of simulations.

Another one of the top Week 13 NFL predictions from the model: The Miami Dolphins (-10.5) cover as home favorites against the Cincinnati Bengals. The Dolphins are 6-1 against the spread in their last seven games and the home team is 4-0 against the spread in the last four meetings between these teams.

Cincinnati has lost three straight and is in the AFC North cellar at 2-8-1. The Bengals are playing out the string without rookie quarterback Joe Burrow, who tore multiple ligaments in his knee against Washington on Nov. 22. Brandon Allen has taken over, though he went just 17-of-29 for 136 yards and a touchdown in a loss to the Giants last week. 

SportsLine's model says the Dolphins cover in over 60 percent of simulations. The over (42.5) also hits more than 60 percent of the time.

How to make Week 13 NFL picks 

The model has also made the call on every other game on the Week 13 NFL schedule and identified a Super Bowl contender that gets a huge scare. You can only get every pick for every game here.

What NFL picks can you make with confidence in Week 13? And which Super Bowl contender get a huge scare? Check out the latest NFL odds from William Hill below and then visit SportsLine to see which NFL teams are covering in more than 50 percent of simulations, all from the model that is up over $7,900 on its top-rated NFL picks

NFL odds, matchups for Week 13

Sunday, Dec. 6

Detroit Lions vs. Chicago Bears (-3, 45) 

Latest Odds: Chicago Bears -3

Cincinnati Bengals vs. Miami Dolphins (-10.5, 42.5)

Latest Odds: Miami Dolphins -11.5

Indianapolis Colts vs. Houston Texans (+3, 51)

Latest Odds: Houston Texans +3

Jacksonville Jaguars vs. Minnesota Vikings (-10, 51)

Latest Odds: Minnesota Vikings -9.5

Las Vegas Raiders vs. New York Jets (+8, 46.5)

Latest Odds: New York Jets +7.5

New Orleans Saints vs. Atlanta Falcons (+3, 46)

Latest Odds: Atlanta Falcons +3

Cleveland Browns vs. Tennessee Titans (-5.5, 53)

Latest Odds: Tennessee Titans -5.5

New York Giants vs. Seattle Seahawks (-10.5, 47.5)

Latest Odds: Seattle Seahawks -10

Los Angeles Rams vs. Arizona Cardinals (+2.5, 48)

Latest Odds: Arizona Cardinals +3

Philadelphia Eagles vs. Green Bay Packers (-9, 49)

Latest Odds: Green Bay Packers -9.5

New England Patriots vs. Los Angeles Chargers (-1.5, 47) 

Latest Odds: New England Patriots PK

Denver Broncos vs. Kansas City Chiefs (-13.5, 51)

Latest Odds: Kansas City Chiefs -14

Monday, Dec. 7 

Washington Football Teams vs. Pittsburgh Steelers (-7, 43.5)

Latest Odds: Pittsburgh Steelers -9.5

Buffalo Bills vs. San Francisco 49ers (-1, 47)

Latest Odds: San Francisco 49ers +2.5

Tuesday, Dec. 8 

Dallas Cowboys vs. Baltimore Ravens (-7.5, 45)