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Ben Queen / USA TODAY Sports

The Week 6 college football schedule features a number of intriguing top-25 matchups, including No. 7 Miami vs. No. 1 Clemson, No. 4 Florida vs. No. 21 Texas A&M, No. 14 Tennessee vs. No. 3 Georgia and No. 19 Virginia Tech vs. No. 8 UNC. Clemson enters Saturday night's showdown against the Hurricanes having won 19 of its last 20 games. However, the Tigers are just 1-4 against the spread in their last five outings. The Week 6 college football odds from William Hill list Clemson as a 15-point favorite at home against Miami. 

The Tigers are 10-0 in their last 10 home games, while Miami is 5-1 against the spread in its last six games against ACC opponents. Will the Hurricanes hang close and cover the spread, or should you look elsewhere for the best value college football bets? Before making any Week 6 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,200 for $100 players on its top-rated college football picks against the spread. It is a sizzling 20-3 on top-rated picks through five weeks of the 2020 college football season, returning over $1,300 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 6 from William Hill and locked in picks for every FBS matchup. Head to SportsLine to see every pick.

Top Week 6 college football predictions 

One of the top Week 6 college football picks the model is recommending: No. 4 Florida (-6.5 at William Hill) wins and covers on the road against No. 21 Texas A&M in a noon ET kickoff on Saturday. The Gators rank fourth nationally in scoring offense with 44.5 points per game as they've rolled to a 2-0 start with wins over South Carolina and Ole Miss. The Aggies, meanwhile, are 1-1 and haven't covered a spread this season. 

The model is projecting Florida quarterback Kyle Trask to throw for almost 300 yards, while tight end Kyle Pitts records 80 yards of receiving and a score, as the Gators win by double digits and cover in almost 60 percent of simulations, making them a great choice for Week 6 college football bets. 

Another one of the top Week 6 college football predictions from the model: No. 5 Notre Dame (-21) covers the spread at home against Florida State. The Seminoles have been successful in this rivalry of late, winning four of the past six meetings against the Fighting Irish. However, Notre Dame enters Saturday's showdown full of confidence after dominating USF 52-0 in its last outing,

Notre Dame's rushing attack had a field day against the Bulls, finishing with over 275 yards on the ground and six rushing touchdowns. Notre Dame is averaging 229.5 yards per game on the ground this season, and now the Fighting Irish will look to exploit a Florida State defense that gave up 200 rushing yards and four rushing touchdowns against Miami earlier this season.

The model is calling for three Fighting Irish running backs to average over 4.0 yards per carry on Saturday against the Seminoles. The model projects that Notre Dame's ground game helps the Fighting Irish cover the spread in nearly 60 percent of simulations on Saturday.

How to make Week 6 college football picks 

The model has also made the call on who wins and covers every other FBS game in Week 6, and it is also predicting an upset in one of the week's biggest games. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 6? And which underdog will pull off a shocking upset? Check out the latest Week 6 college football odds below for some of the week's most notable games, and then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $4,200 in profit over the past four-plus seasons, and find out.

Week 6 college football odds (via William Hill)

Virginia Tech at North Carolina (-5.5)
Texas at Oklahoma (-2.5)
Florida at Texas A&M (+6.5)
South Carolina at Vanderbilt (+12)
Duke at Syracuse (+1.5)
Tennessee at Georgia (-14)
Texas Tech at Iowa State (-12.5)
Kansas State at TCU (-9)
Pittsburgh at Boston College (+4.5)
Arkansas at Auburn (-14)
Alabama at Ole Miss (+24)
Mississippi State at Kentucky (-3)
Miami (FL) at Clemson (-15)
LSU at Missouri (+14)
Florida State at Notre Dame (-20.5)