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We've had some big injuries already this season with Dez Bryant, Tony Romo and Ben Roethlisberger all sidelined for several weeks. On Sunday, we had what is likely the biggest injury of all to Jamaal Charles.

It's not confirmed yet, but Chiefs coach Andy Reid said preliminary reports show Charles suffered a torn ACL in Week 5 against the Bears. Charles went down in the third quarter and clutched his right knee, and he had to be carried off the field. He finished what could be his last game of the season with 12 carries for 58 yards and one catch for 26 yards.

Charles will undergo an MRI on Monday, but you should expect the worst. In 2011, Charles tore the ACL in his left knee in the second week of the season, and he missed the remainder of the year. And now we have to figure out who will replace Charles in Kansas City's offense.

Coming into the season, it was thought Knile Davis was the clear-cut handcuff for Charles. There have been six times in Davis' two-year career where he's gotten at least 16 carries, and he's reached double digits in Fantasy points in a standard league every time.

But the Chiefs have started using Charcandrick West as the backup to Charles the past two weeks. In Week 4 at Cincinnati, West had 5 carries for 17 yards and one catch for 4 yards, and he had seven carries for 31 yards and one catch for 5 yards against the Bears. Meanwhile, Davis went two games without an offensive touch before getting two carries for 2 yards against Chicago.

West is the running back to target off the waiver wire if Charles is out for the season, but we should expect West and Davis to split the workload for the Chiefs, according to Reid. Hopefully we'll get some answers from Reid this week, but plan to spend a lot of your FAAB on West since he could emerge as a must-start Fantasy option as early as Week 6 at Minnesota. Davis is also worth adding where available.

Quarterbacks

Player on the rise

Josh McCown
HOU • QB • 3
Week 536/51 COMP/ATT, 457 YDS, 2/0 TD/INT, 39 FPTS
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Josh McCown is never going to make Fantasy owners comfortable as a starter, but the past three weeks have been impressive. He's scored at least 23 Fantasy points in each game over that span, including 39 points in Week 5 at Baltimore with 457 passing yards and two touchdowns and 12 carries with a rushing score. He's taken advantage of great matchups against Oakland, San Diego and Baltimore, but he'll likely get a reality check in Week 6 against Denver. The Broncos have yet to allow a quarterback to throw multiple touchdowns this season, and McCown will likely get shut down. But if he comes out of that game with another solid performance then it might be time to buy into McCown as a quality Fantasy option this season. Just keep an eye on his ankle after he hurt himself on the final drive against the Ravens, although he's expected to be fine for Week 6.

Player on the decline

Matthew Stafford
LAR • QB • 9
Week 520/32 COMP/ATT, 188 YDS, 1/3 TD/INT, 7 FPTS
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The reason Matthew Stafford gets this spot ahead of Peyton Manning is because Stafford was actually benched for Dan Orlovsky in Detroit's loss against Arizona. He was 20-of-32 passing for 188 yards, one touchdown and three interceptions before leaving the game, and he has now combined for 26 Fantasy points in his past three games, with just one game over 17 points this season. Coach Jim Caldwell has already said Stafford will start in Week 6 against Chicago, which was thought to be when Stafford would change his fortunes. But now you can't trust him even in what should be a good matchup against the Bears at home.

Quarterback injuries: Josh McCown (ankle)
Quarterback waivers: Jay Cutler (53 percent ownership), Blake Bortles (47 percent) and Josh McCown (17 percent)
Of note: Eli Manning is proving to be the best Fantasy quarterback of his family in 2015 after he passed for 441 yards, three touchdowns and one interception against the 49ers on Sunday night. He has now scored at least 23 Fantasy points in four games in a row and should be considered a must-start Fantasy option every week until he proves otherwise. ... Colin Kaepernick rebounded from two dud games with a solid outing against the Giants with 250 passing yards and two touchdowns and 23 rushing yards for 24 Fantasy points. He has a favorable matchup against the Ravens at home in Week 6 and is worth using in two-quarterback leagues. ... Peyton Manning is getting one more chance from me before it's time to consider benching him in the majority of leagues. He faces the Browns in Week 6, and Cleveland has allowed every opposing quarterback this season to score multiple touchdowns, including Joe Flacco in Week 5. Manning was again terrible in Week 5 at Oakland with six Fantasy points, which gives him three games this year with 10 points or less. He has five interceptions in his past three games, and this has been a rough start. But let's see how does at Cleveland in Week 6 before we abandon him as a starter. ... One quarterback you might consider using instead of Manning is Bortles, who had a career game in Week 5 with 303 passing yards, four touchdowns and an interception and 21 rushing yards at Tampa Bay for 36 Fantasy points. He's now scored at least 19 Fantasy points in four games in a row, and he gets a favorable matchup in Week 6 against the Texans, who have allowed three quarterbacks to score multiple touchdowns this season. Bortles is getting quality play from his receiving corps, including Julius Thomas returning against the Buccaneers. ... Has Andy Dalton become matchup proof? You'd have to say yes after his performance against Seattle in Week 5. Dalton scored 30 Fantasy points against the Seahawks, which gives him four games this season of at least 22 points and no games lower than 19. He'll look to stay hot at Buffalo in Week 6, and you should continue to start Dalton in all leagues until he proves otherwise. ... Sam Bradford wasn't perfect against the Saints on Sunday with two interceptions, but he still had 333 passing yards and two touchdowns and finished with 20-plus Fantasy points for the second game in a row. We hope this is a sign of things to come for him, and he's worth starting again in Week 6 against the Giants on Monday night. ... Cutler had one of the craziest game-winning touchdowns you'll ever see when he dropped the snap, picked up the football and found Matt Forte in the end zone for the go-ahead score at Kansas City. He finished with 21 Fantasy points for the second game in a row, but this outing was impressive since Alshon Jeffery (hamstring) and Eddie Royal (ankle) were both out. We'd love to see what Cutler can do with a healthy receiving corps, and maybe we'll get that in Week 6 at Detroit. He should be considered a low-end starter against the Lions. ... For the second game in a row, Drew Brees had his Fantasy production saved by a late touchdown, this time from Brandin Cooks. He finished with just 19 Fantasy points, but he had 335 passing yards, two touchdowns and one interception on 26-of-43 passing. His shoulder issue shouldn't be much of a concern moving forward. ... Two quarterbacks to buy low on are Aaron Rodgers and Matt Ryan if you can find some impatient owners. Rodgers had fewer than 20 Fantasy points for the second game in a row with his 18-point outing against St. Louis on Sunday, and Ryan has scored fewer than 17 Fantasy points in consecutive games with his six-point performance against Washington. Plenty of big games are ahead for both quarterbacks, so see if you can get them cheap now. ... Russell Wilson could be another quarterback to target as a buy-low candidate after he scored 17 Fantasy points or less for the third game in a row at Cincinnati (14 points) and the fourth time this season. His offensive line is a mess, and he's yet to score a rushing touchdown. He has a tough matchup in Week 6 against Carolina, but things soften up following that at San Francisco and at Dallas before a bye in Week 9. I considered Wilson a bust candidate prior to the season, but I'd still try to get him cheap now if possible.

Running backs

Player on the rise

Doug Martin
LV • RB • 22
Week 527 TOUCHES, 158 TOTAL YDS, 3 TOTAL TD, 33 FPTS
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It's too bad Tampa Bay has a bye in Week 6 because Doug Martin is getting hot with at least 19 Fantasy points in his past two games, including 33 points against Jacksonville in Week 5. He now has three games this season with at least 20 carries, and he's also caught eight passes in the past two games for 72 yards and a touchdown. Charles Sims has also played well for the Buccaneers with three games in a row with at least 11 Fantasy points, and he's worth adding where available at 62 percent ownership on CBS Sports leagues. But Martin is the better running back in Tampa Bay, and hopefully he'll continue to play at a high level after the bye.

Player on the decline

Eddie Lacy
SEA • RB • 27
Week 513 ATT, 27 YDS, 0 TD, 2 FPTS
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Fantasy owners should try and buy low on Eddie Lacy now because it's only a matter of time before he starts playing at a high level. He was terrible in Week 5 against the Rams with two Fantasy points, and he's now scored just 19 Fantasy points combined in his past three games. James Starks continues to steal touches from Lacy, but big games should start to happen soon. I'm excited about his matchup against the Chargers in Week 6, so your window to get him at a bargain price might only be for this week.

Running back injuries: Jamaal Charles (knee), T.J. Yeldon (groin), Justin Forsett (ankle) and Matt Jones (toe)
Running back waivers: Darren McFadden (60 percent ownership), Thomas Rawls (57 percent), Knile Davis (51 percent), Theo Riddick (30 percent), Antonio Andrews (22 percent), Javorius Allen (5 percent) and Charcandrick West (1 percent)
Of note: Carlos Hyde must like playing on prime time. He was a stud in Week 1 on Monday night against the Vikings, but hasn't done much since - until Sunday night against the Giants. Hyde had 21 carries for 93 yarShane Vereen was great in the passing game. He had five carries for 24 yards and eight catches for 86 yards and a touchdown on eight targets. He will likely be the only consistent Giants running back moving forward because of his ability to catch the ball. ... Devonta Freeman has easily been the Fantasy MVP through the first five weeks of the season. He had another dominant performance in Week 5 against the Redskins with 27 carries for 153 yards and a touchdown and seven catches for 44 yards. He's now scored at least 25 Fantasy points in three games in a row and became the first player in the Super Bowl era (since 1966) to rush for at least seven touchdowns in his first three starts to begin a career, according to the NFL. He should have a field day against the Saints on Thursday night in Week 6. ... We hope Forsett is OK after appearing to hurt his ankle late in Sunday's game against the Browns. Prior to going down, he did well as our Start of the Week with 21 carries for 121 yards and a touchdown and four catches for 49 yards, which was 22 Fantasy points. If he's out for Week 6 at San Francisco then look for Allen and Lorenzo Taliaffero to split touches against the 49ers. We would look at Allen first off waivers. ... Yeldon scored his first NFL touchdown on a reception, and he finished with 11 carries for 32 yards and five catches for 31 yards and the score against Tampa Bay before hurting his groin. After the game, Yeldon said the injury wasn't serious, but it's worth monitoring heading into Week 6 against Houston. ... Rawls was miserable against the Lions in Week 4 with 17 carries for 48 yards, but he looked dominant at Cincinnati with 23 carries for 169 yards and a touchdown and now has double digits in Fantasy points in two of his past three games. We'll find out if Marshawn Lynch (hamstring) is able to return in Week 6 against the Panthers, but if he's out then Rawls should be considered a No. 2 Fantasy running back in most leagues. ... Todd Gurley again put on a show in Week 5 at Green Bay with 30 carries for 159 yards, and he's now rushed for 305 yards on 49 carries in the past two games. The Rams are on a bye in Week 6, but Gurley should be awesome in Week 7 against the Browns, so hopefully he'll stay hot coming off his break. ... DeMarco Murray wanted more work, and he got it in Week 5 against New Orleans with 20 carries for 83 yards and a touchdown and seven catches for 37 yards. He looked like a workhorse running back, and we hope that's a sign of things to come, although you might want to sell high in case someone gives you a good offer for him. Keep in mind, Murray has not run well this year and also dealt with a hamstring injury, and the Saints have a terrible defense. Ryan Mathews also contributed with eight carries for 73 yards and a touchdown and three catches for 23 yards. ... The Broncos rush offense was as bad as the pass offense as Ronnie Hillman had seven carries for 21 yards and one catch for 5 yards, and C.J. Anderson had 11 carries for 22 yards and two catches for 18 yards at Oakland. So much for Hillman getting more work this week. Like Manning, let's see what happens next week at Cleveland since the Browns allow plenty of Fantasy points to opposing running backs, but one of these guys needs to separate themselves so Fantasy owners can find a trustworthy option. ... The Lions benched Ameer Abdullah after he lost one fumble and then almost coughed up a second one, and he finished with six carries for 17 yards and one catch for 9 yards against Arizona. He's failed to take advantage of Joique Bell (ankle) being out, and it will be hard to trust him even in a plus matchup against the Bears in Week 6. Riddick continues to make plays for owners in PPR leagues, and he had 10 catches for 53 yards and a touchdown against the Cardinals. This is now three games in a row with at least five catches and two of his past three with at least eight catches. ... Speaking of PPR leagues, McFadden will be the replacement for Lance Dunbar (knee) in Dallas. McFadden had nine catches for 62 yards on 10 targets against the Patriots, and he also added five carries for 16 yards. Joseph Randle had 15 carries for 60 yards and four catches for 13 yards, but McFadden is worth adding where available in PPR leagues. ... The Patriots once again got a great performance out of Dion Lewis with six carries for 34 yards and eight catches for 59 yards and a touchdown at Dallas. He's now scored in double digits in Fantasy points in four games in a row, and we expect him to remain relevant all year. LeGarrette Blount added 13 carries for 74 yards, and he could be a great starter in Week 6 at Indianapolis. He had 30 carries for 148 yards and three touchdowns against the Colts in the AFC Championship Game last year. ... The Cardinals had three running backs reach double digits in Fantasy points in Week 5 at Detroit with Chris Johnson getting 11 carries for 103 yards, Andre Ellington having three carries for 63 yards and a touchdown and David Johnson with three carries for 6 yards and two touchdowns. I'd rank them Chris Johnson, Ellington and David Johnson for the rest of the season, but David Johnson appears locked in as the goal-line back. Johnson, who has three rushing touchdowns, two receiving touchdowns and a kickoff-return touchdown this season, is the first rookie since Pro Football Hall of Famer Gale Sayers (1965) to have multiple rushing touchdowns, multiple receiving touchdowns and a kickoff-return touchdown in his team's first five games of a season, according to the NFL. ... Don't panic again on Jeremy Hill with his bad game against the Seahawks with eight carries for 13 yards and one catch for 12 yards. This was a tough matchup, and we expected Giovani Bernard to be better, which he was with 15 carries for 80 yards and five catches for 21 yards. The same could happen again in Week 6 at Buffalo, but buy low on Hill now because the best is yet to come.

Wide receivers

Player on the rise

Allen Hurns
MIA • WR • 8
Week 55 REC, 116 YDS, 1 TD, 17 FPTS
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Allen Hurns had his third big game in a row at Tampa Bay with five catches for 116 yards and a touchdown on six targets, and he's now scored at least 13 Fantasy points in each game over that span. Allen Robinson also played well against the Buccaneers with seven catches for 72 yards and two touchdowns on nine targets, and both receivers should be considered No. 2 Fantasy options in the majority of leagues moving forward.

Player on the decline

Jordan Matthews
SF • WR • 88
Week 55 REC, 44 YDS, 0 TD, 4 FPTS
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Jordan Matthews was really a non-factor Sunday against the Saints with five catches for 44 yards on seven targets. He dropped a touchdown that would have been negated by a penalty, but he has now scored just 13 Fantasy points combined in his past three games and has only one touchdown on the season. He needs to step up his performance in Week 6 against the Giants before Fantasy owners begin to completely lose faith.

Wide receiver injuries: Nelson Agholor (ankle), Marques Colston (shoulder), Rueben Randle (hamstring) and Kenny Britt (shoulder)
Wide receiver waivers: Andre Johnson (65 percent ownership), Tavon Austin (48 percent), Willie Snead (38 percent), Kamar Aiken (34 percent), Brandon LaFell (30 percent), Ty Montgomery (19 percent), Jamison Crowder (6 percent), Marquess Wilson (4 percent) and Josh Huff (1 percent)
Of note: Odell Beckham dealt with a hamstring injury Sunday night against the 49ers, but he finished with seven catches for 121 yards and a touchdown on 11 targets. After the game, Beckham said he wasn't concerned with the injury. Randle also hurt his hamstring against the 49ers, and we'll find out the extent of his injury during the week. Randle had five catches for 42 yards on six targets. ... Anquan Boldin looked impressive against the Giants with eight catches for 107 yards on 12 targets. He should be fired up to his face his former team in Week 6 when the Ravens travel to San Francisco. ... My colleague Dave Richard and I had a spirited debate on our podcast Friday about Cooks, and he made me look good with a garbage-time touchdown at Philadelphia. He finished with five catches for 107 yards and the touchdown on nine targets, and Brees also missed him on a touchdown in the first half. I have no concerns about Cooks moving forward, and Snead also played well with six catches for 141 yards. Snead now has at least five catches in his past three games and more than 80 yards in his past two outings. ... If the Bears continue to play without Jeffery and Royal then look at Wilson as a solid add off waivers. He has 12 catches for 165 yards and a touchdown on 17 targets in his past two games. ... John Brown had his best game of the season in Week 5 at Detroit with four catches for 73 yard and a touchdown on four targets. He should continue to play well, and it was nice to see him and Larry Fitzgerald score in the same game this season. Fitzgerald had five catches for 58 yards and a touchdown on seven targets, and he continues to prove he's a Top 10 Fantasy receiver when Carson Palmer is healthy. ... It sounds like DeSean Jackson (hamstring) is close to a return, but look at Crowder off waivers if you need a receiver in PPR leagues. He had eight catches for 87 yards on eight targets against the Falcons on Sunday and now has at least six catches in his past three games. ... I wouldn't drop Terrance Williams yet as some of you have asked about on Twitter, and we'll see what the Cowboys do at quarterback coming off their bye in Week 6. Tony Romo (collarbone) remains out, but Dallas needs to replace Brandon Weeden with Matt Cassel. Williams was wide open for a touchdown on the Cowboys last play against the Patriots, but Weeden overthrew him, leaving Williams with just two catches for 30 yards on six targets. ... Aiken didn't play as well as I hoped against the Browns, but he still led the team with four catches for 78 yards on nine targets. We'll find out if Steve Smith (back) is able to play in Week 6 at San Francisco, but if he's out then Aiken should remain a serviceable No. 3 Fantasy receiver in all leagues. ... Austin scored his third touchdown in the past two games, and he finished with two catches for 6 yards on five targets and three carries for 22 yards at Green Bay. It's nice to see him making plays for the Rams, and the touchdowns are great. But he's still too fluky of a Fantasy option for me to trust because I'd rather believe in a receiver with a higher target volume. ... Mike Evans and Vincent Jackson were both miserable against Jacksonville with a combined four catches for 55 yards and no touchdowns on eight targets. Tampa Bay wasn't chasing points in this game, and Martin was rolling, so Evans and Jackson weren't really needed. We don't expect the Buccaneers to be in that position most weeks, so don't give up on Evans or Jackson just yet.

Tight ends

Player on the rise

Gary Barnidge
CLE • TE • 82
Week 58 REC, 139 YDS, 1 RD, 19 FPTS
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Gary Barnidge continues to prove he should be considered a must-start tight end with his performance over the past three weeks. He had eight catches for 139 yards and a touchdown on 10 targets at Baltimore, and he's now scored at least 13 Fantasy points in three games in a row. He has a tough matchup in Week 6 against Denver, but Barnidge should definitely be added in all leagues where available. It's clear he has a great rapport with McCown with 26 targets during this three-game stretch.

Player on the decline

Jimmy Graham
CHI • TE • 80
Week 53 REC, 30 YDS, 0 TD, 3 FPTS
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Jimmy Graham continues to be one of the biggest busts of the year after another bad game in Week 5 at Cincinnati. He had just three catches for 30 yards on five targets and has now scored three Fantasy points or less in three of his past four games. Twice this season Graham has had more than five targets, and both times he's had at least 50 receiving yards and a touchdown. It's pretty clear Wilson needs to get Graham more involved in the offense.

Tight end injuries: Delanie Walker (hip)
Tight end waivers: Gary Barnidge (57 percent ownership), Zach Ertz (42 percent), Brent Celek (3 percent), Jacob Tamme (3 percent) and Derek Carrier (2 percent)
Of note: Tyler Eifert had another monster game in Week 5 against the Seahawks with eight catches for 90 yards and two touchdowns on 12 targets. This is now two games this season with at least 20 Fantasy points, and he's more than delivered already on the preseason hype. ... The Eagles got eight catches for 104 yards and a touchdown on 10 targets from Ertz and Celek against the Saints. We wish one guy would emerge from this duo, but if you're looking for a tight end in a great matchup for Week 6 then go for Ertz against the Giants. New York allowed Garrett Celek to score in Week 5 for the 49ers, and the Giants have struggled with tight ends all season. ... Another tight end with a great matchup is Tamme since the Saints are bad against tight ends also, as evidenced by the Eagles. Tamme had eight catches for 94 yards on 10 targets against the Redskins and now has at least seven Fantasy points in a standard league in two games this season. ... Julius Thomas returned for the Jaguars at Tampa Bay after missing the first four games with a hand injury, but he played just in passing situations. He finished with two catches for 20 yards on two targets, but it was good to get him back on the field for the first time this year. ... Larry Donnell had the game-winning catch for the Giants against the 49ers and finished with six catches for 35 yards and a touchdown on seven targets. He has a tough matchup in Week 6 against the Eagles, but hopefully Donnell will continue to be involved for the Giants. ... Garrett Celek took advantage of the matchup against the Giants with three catches for 26 yards and a touchdown on five targets. He'll be a good option in deeper leagues in Week 6 against Baltimore if Vernon Davis (knee) again remains out.