NCAA Football: Texas A&M at Alabama
Gary Cosby Jr / USA TODAY Sports

In what could wind up being a College Football Playoff elimination game, No. 1 Clemson will visit No. 4 Notre Dame on Saturday with the lead in the ACC standings hanging in the balance. The Tigers won't have junior quarterback Trevor Lawrence available because of a positive COVID-19 test two weeks ago. Freshman D.J. Uiagalelei will have his work cut out against Notre Dame's vaunted defense. However, the nation's top-ranked team is still listed as a five-point favorite in the Week 10 college football odds from William Hill Sportsbook.

Meanwhile, Pac-12 play will begin with No. 12 Oregon hosting Stanford on Saturday night for a 7:30 p.m. ET kickoff. With just a six-game season scheduled, Oregon will have to impress every step along the way and the Ducks are listed as eight-point favorites in Autzen Stadium in their Pac-12 opener. Before locking in any Week 10 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past four-plus years, the proprietary computer model has generated a stunning profit of over $4,100 for $100 players on its top-rated college football picks against the spread. It is a sizzling 31-19 on all top-rated picks through nine weeks of the 2020 college football season, returning over $600 in profit already. Anybody who has followed it is way up. 

Now, it has turned its attention to the latest college football odds for Week 10 from William Hill and locked in picks for every FBS matchup. Head here to see every pick.

Top Week 10 college football predictions 

One of the top Week 10 college football picks the model is recommending: No. 23 Michigan (-4) wins and covers at No. 13 Indiana in an important Big Ten matchup at noon ET on Saturday. The Wolverines blasted Minnesota 49-24 in their first game but fell 27-24 against rival Michigan State last week. 

The model, however, sees great value in the Wolverines in a bounce-back spot against an Indiana squad that might be overvalued after its 2-0 start. The road team is 3-0-1 against the spread in the last four meetings between these squads. Michigan has also won 24 straight against the Hoosiers and has won by double-digits in the past two meetings. 

SportsLine's model is calling for 250 passing yards and two touchdowns from Michigan quarterback Joe Milton as the Wolverines cover in almost 70 percent of simulations. 

Another one of the top Week 10 college football predictions from the model: Arkansas (+1.5) stays within the spread against Tennessee in a 7:30 p.m. ET matchup at Donald W. Reynolds Stadium. After opening the season with a pair of solid wins over South Carolina and Missouri, Tennessee had major issues offensively against Georgia, Kentucky and Alabama.

Coming out of a bye week, Tennessee has announced that it will stick with Jarrett Guarantano as the starting quarterback despite the fact that he's averaging just 4.6 yards per pass attempt in his last three starts. The Volunteers have turned the ball over eight times and have been outgained by 509 yards during that span to lose by an average of 27 points per game.

Arkansas has had some offensive issues of its own, but the defense has been opportunistic in spurts. The Razorbacks forced seven turnovers against Ole Miss and four turnovers against Mississippi State in victories and also played Auburn and Texas A&M extremely tough on the road. That's why the model has Arkansas covering in over 60 percent of simulations with the under 52.5 hitting in nearly 70 percent of projections.

How to make Week 10 college football picks 

The model has also made the call on who wins and covers in No. 1 Clemson vs. No. 4 Notre Dame as well as every other Week 10 FBS matchup, and it is also predicting a major upset in the Pac-12. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence in Week 10? And which Pac-12 underdog will pull off a shocking upset? Check out the latest Week 10 college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $4,100 in profit over the past four-plus seasons, and find out.

Week 10 college football odds (via William Hill)

Saturday, Nov. 7

North Carolina at Duke (+10)
Nebraska at Northwestern (-4)
Liberty at Virginia Tech (-14.5)
West Virginia at Texas (-7)
Michigan State at Iowa (-7)
Michigan at Indiana (+4)
Arizona State at USC (-10.5)
South Florida at Memphis (-17.5)
Boston College at Syracuse (+14)
Kansas at Oklahoma (-38)
Maryland at Penn State (-25)
Florida at Georgia (-3)
Houston at Cincinnati (-11.5)
Pittsburgh at Florida State (+1)
Oklahoma State at Kansas State (+10.5)
Baylor at Iowa State (-13.5)
UCLA at Colorado (+5.5)
Texas A&M at South Carolina (+7.5)
Tennessee at Arkansas (+1.5)
Stanford at Oregon (-9)
Clemson at Notre Dame (+5)
South Alabama at Coastal Carolina (-16.5)
Washington State at Oregon State (+2.5)