49ers' Yetur Gross-Matos: Now dealing with knee injury
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Gross-Matos (knee) did not practice Wednesday, per the NFL's injury report.
Gross-Matos was activated from injured reserve prior to the 49ers' Week 16 contest against the Colts, which was his first game back from a 10-game absence due to a hamstring injury. However, the sixth-year defensive end is now working through a knee injury, and he would need to practice in full by Friday in order to avoid an injury tag against the Bears on Sunday.
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49ers' Renardo Green: Limited to open Week 17 prep
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Green (neck) was a limited participant in Wednesday's practice, per the NFL's injury report.
Green was unable to play in Monday's win against the Colts due to a neck injury. He's opened the week with a limited practice and will need to practice fully by Friday to avoid an injury designation for Sunday's game against Chicago. The 2024 second-rounder has accumulated 52 tackles (30 solo) and nine pass defenses through 13 regular-season games.
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49ers' Tatum Bethune: Ankle injury not a concern
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Bethune (ankle) was a full participant in Wednesday's practice, per the NFL's injury report.
Bethune aggravated an ankle injury during the 49ers' Week 16 win over the Colts on Monday. However, his full practice Wednesday indicates that the injury isn't considered a long-term issue and puts him on track to be available for Sunday's game against the Bears.
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49ers' Ji'Ayir Brown: Productive in Week 16 victory
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Brown tallied nine tackles (five solo) and forced a fumble Monday in a 48-27 win against the Colts.
Brown tied for the 49ers' lead in tackles, with three of his stops coming on special teams. He also forced a fumble that was recovered by San Francisco as part of that unit, setting up his team's second touchdown of the game. Brown's nine total stops were his second-most in a game this season, topped only by the 10 tackles he recorded in Week 10 against the Rams.
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49ers' Malik Mustapha: Makes eight stops in Week 16 win
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Mustapha tallied eight tackles (three solo) in Monday's 48-27 victory against Indianapolis.
Mustapha's tackle total was third-highest on San Francisco. The second-year safety has been a steady IDP asset of late, posting at least seven stops in each of his past four games.
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49ers' Dee Winters: Seals win with pick-six
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Winters logged three tackles (one solo) and two defensed passes, including an interception that he returned for a touchdown, in Monday's 48-27 victory versus the Colts.
Winters had a pretty quiet day from a tackling perspective, finishing with his lowest total since Week 12. However, he made perhaps the biggest defensive play of the game when he intercepted a Phillip Rivers pass with less than four minutes remaining and returned it 74 yards for a touchdown to extinguish any hope of an Indianapolis comeback. That was Winters' first interception and first touchdown in his three seasons as a pro.
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49ers' Tatum Bethune: Exits game with ankle injury
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Bethune (ankle) is questionable to return to Monday's game against the Colts.
Bethune missed the 49ers' last three games due to an ankle injury, but it's not clear whether he aggravated the injury or if it's new. While he's being evaluated by medical staff, veteran Eric Kendricks -- who was elevated from the practice squad to the active roster ahead of Monday's game -- has entered the game to serve as the 49ers' middle linebacker.
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49ers' Yetur Gross-Matos: Active for MNF
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Gross-Matos (hamstring) is active for Monday night's game against the Colts.
The Niners activated the veteran defensive lineman from injured reserve earlier Monday, and he'll return to the lineup for the first time since being injured in Week 5.
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49ers' Curtis Robinson: Inactive against Indy
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Robinson (coach's decision) is inactive for Monday night's game against the Colts.
With the Niners deciding to elevate Eric Kendricks from the practice squad, Robinson is the odd man out in the linebacker corps. Robinson has appeared in all 14 games to this point this season, making three starts, and has produced 42 tackles (19 solo) and one pass breakup.
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49ers' Eric Kendricks: Joins active roster
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Kendricks was elevated from the 49ers' practice squad to the active roster Monday.
The 33-year-old joined the 49ers' practice squad in late November and is now in line to make his first appearance of the 2025 season during Monday night's matchup against the Colts. Kendricks last played for the Cowboys in 2024, recording 138 total tackles, including 3.0 sacks, three passes defensed, with two interceptions, and three forced fumbles over 15 contests. Now with San Francisco's active roster, Kendricks is expected to operate as one of the team's top inside linebackers.
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49ers' Yetur Gross-Matos: Activated Monday
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Gross-Matos (hamstring) was activated off the 49ers' injured reserve list Monday, Adam Schefter of ESPN reports.
The Penn State product has not played since San Francisco's Week 5 win over the Rams due to a hamstring injury, but it now appears he's nearing a return. Despite being activated off IR, Gross-Matos is still listed as questionable for Monday night's matchup against the Colts. If active for the Week 16 contest, he'll likely operate as one of the 49ers' top reserve defensive ends.
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49ers' Jordan Elliott: Ready for Week 16
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Elliott (knee) does not carry an injury designation for Monday's game against the Colts.
Elliott is ready to return to the field for the first time since he injured his knee in Week 13 against the Browns. He'll resume handling a key rotational role along San Francisco's defensive line behind Kalia Davis and rookie second-round pick Alfred Collins.
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49ers' Sam Okuayinonu: Ready to face Colts
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Okuayinonu (ankle) does not carry an injury designation for Monday's game against Indianapolis.
Okuayinonu will retake the field for the first time since suffering an ankle injury versus the Browns in Week 12. He's expected to resume handling a starting role at defensive end on the road against the Colts on Monday night.
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49ers' Tatum Bethune: Ready to rock
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Bethune (ankle) is cleared for Monday's game against the Colts, Matt Barrows of The Athletic reports.
Coach Kyle Shanahan said Bethune is "good to go" Saturday. The starting middle linebacker figures to resume handling his usual every-down role in his first return to action since Week 11. Prior to injuring his ankle, Bethune had racked up five straight games with double-digit tackles.
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49ers' Yetur Gross-Matos: Officially questionable for Week 16
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Gross-Matos (hamstring/knee) is officially listed as questionable for Monday's game against the Colts, Matt Maiocco of NBC Sports Bay Area reports.
Gross-Matos began Week 16 as a limited participant upon having his 21-day practice window opened. He'll need to be activated from IR in advance of Monday's matchup in order to be eligible to take the field versus Indianapolis.
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49ers' Renardo Green: Ruled out for Monday's game
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Green (neck) has been ruled out for Monday's contest against the Colts, Matt Maiocco of NBC Sports Bay Area reports.
Green won't be available for Monday night's contest, leaving Darrell Luter and Chase Lucas as candidates to handle an expanded role at cornerback alongside Deommodore Lenoir and Upton Stout. His next chance to return to action is in Week 17 against the Bears.
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49ers' Nick Martin: Lands on IR
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The 49ers placed Martin (concussion) on injured reserve Saturday.
Martin will miss the remainder of the regular season, but he could come off IR and resume contributing if San Francisco makes the playoffs. The rookie third-round pick has tallied 11 tackles (eight solo) and one forced fumble across seven regular-season appearances.
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49ers' Tatum Bethune: Limited again Friday
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Bethune (ankle) was a limited participant in Friday's practice, Nick Wagoner of ESPN.com reports.
Bethune has now strung together consecutive limited practices and seems to be trending towards playing in Monday night's game against the Colts. The middle linebacker will have one more opportunity to attempt to upgrade to a full participant and avoid an injury designation ahead of Monday's game.
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49ers' Sam Okuayinonu: Logs limited practice
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Okuayinonu (ankle) logged a limited practice Thursday, Cam Inman of The San Jose Mercury News reports.
This marked Okuayinonu's first practice since suffering an ankle injury in San Francisco's Week 12 matchup. Though it's a positive sign, his status for Monday's game against the Colts remains unclear.
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49ers' Renardo Green: Starts week with limited session
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Green (neck) practiced in limited fashion Thursday, Cam Inman of The San Jose Mercury News reports.
Green played 98 percent of snaps and logged four tackles in San Francisco's win over Tennessee in Week 15, so it's unclear when the injury occurred. There doesn't seem to be too much reason for concern regarding his status for Monday's game against the Colts, but his level of participation for the rest of the week will be worth monitoring.
