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| Astros 1st | |
| Rich Harden pitching: | |
| Kazuo Matsui: | Strike looking, Matsui grounded out to second. |
| Miguel Tejada: | Tejada flied out to right. |
| Hunter Pence: | Strike looking, Strike looking, Pence struck out swinging. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
| Cubs 1st | |
| Wandy Rodriguez pitching: | |
| Alfonso Soriano: | Strike looking, Soriano flied out to center. |
| Ryan Theriot: | Ball, Ball, Ball, Theriot walked. |
| Derrek Lee: | Strike looking, Ball, Ball, Lee doubled to left, Theriot to third. |
| Aramis Ramirez: | Ramirez grounded out to pitcher. |
| Reed Johnson: | Johnson hit by pitch. |
| Mark DeRosa: | Ball, Strike looking, Foul, Ball, DeRosa doubled to right, Theriot and Lee scored, Johnson to third. |
| Kosuke Fukudome: | Strike looking, Strike swinging, Ball, Fukudome flied out to left. |
| End of Inning (2 Runs, 2 Hits, 0 Errors) | |
| Astros 2nd | |
| Rich Harden pitching: | |
| Carlos N. Lee: | Ball, Strike swinging, Foul, Foul, Lee grounded out to third. |
| Geoff Blum: | Ball, Strike swinging, Blum singled to right. |
| Ty Wigginton: | Ball, Foul, Ball, Ball, Foul, Foul, Foul, Pickoff attempt, Wigginton struck out swinging, Blum to second on DeRosa's fielding error. |
| Darin Erstad: | Strike swinging, Erstad singled to right, Blum scored. |
| Humberto Quintero: | Strike (foul tip), Foul, Quintero struck out on foul tip. |
| End of Inning (1 Run, 2 Hits, 1 Error) | |
| Cubs 2nd | |
| Wandy Rodriguez pitching: | |
| Henry Blanco: | Strike looking, Foul, Blanco doubled to left. |
| Rich Harden: | Harden reached on bunt single to pitcher, Blanco to third. |
| Alfonso Soriano: | Ball, Ball, Strike swinging, Soriano singled to left center, Blanco scored, Harden to second. |
| Ryan Theriot: | Ball, Bunt foul, Theriot popped out to pitcher. |
| Derrek Lee: | Ball, Strike looking, Lee singled softly to right, Harden to third, Soriano to second. |
| Aramis Ramirez: | Ball, Ball, Ball, Ramirez walked, Harden scored, Soriano to third, Lee to second. |
| Reed Johnson: | Johnson hit sacrifice fly to center, Soriano scored. |
| Mark DeRosa: | Ball, Strike looking, DeRosa singled to left, Lee scored, Ramirez to second. |
| Kosuke Fukudome: | Strike swinging, Foul, Fukudome flied out to deep left. |
| End of Inning (4 Runs, 5 Hits, 0 Errors) | |
| Astros 3rd | |
| Rich Harden pitching: | |
| Wandy Rodriguez: | Ball, Strike looking, Rodriguez grounded out to shortstop. |
| Kazuo Matsui: | Strike looking, Ball, Foul, Matsui flied out to right. |
| Miguel Tejada: | Strike looking, Foul, Foul, Foul, Foul, Tejada grounded out to third. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
| Cubs 3rd | |
| Wandy Rodriguez pitching: | |
| Henry Blanco: | Strike looking, Strike looking, Ball, Ball, Foul, Ball, Blanco grounded out to shortstop. |
| Rich Harden: | Ball, Ball, Harden flied out to center. |
| Alfonso Soriano: | Ball, Soriano flied out to left. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
| Astros 4th | |
| Rich Harden pitching: | |
| Hunter Pence: | Pence flied out to right. |
| Carlos N. Lee: | Ball, Foul, Strike looking, Ball, Foul, Lee struck out swinging. |
| Geoff Blum: | Strike looking, Foul, Foul, Blum struck out swinging. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
| Cubs 4th | |
| Wandy Rodriguez pitching: | |
| Ryan Theriot: | Ball, Theriot grounded out to second. |
| Derrek Lee: | Strike looking, Ball, Strike looking, Ball, Lee singled to left center. |
| Aramis Ramirez: | Ball, Strike looking, Ball, Ramirez singled to center, Lee to second. |
| Reed Johnson: | Strike looking, Foul, Johnson popped out to second. |
| Mark DeRosa: | DeRosa popped out to second. |
| End of Inning (0 Runs, 2 Hits, 0 Errors) | |
| Astros 5th | |
| Rich Harden pitching: | |
| Ty Wigginton: | Ball, Strike looking, Ball, Wigginton homered to left center. |
| Darin Erstad: | Strike (missed bunt), Erstad singled to left center. |
| Humberto Quintero: | Strike looking, Strike swinging, Foul, Ball, Quintero struck out on foul tip. |
| Wandy Rodriguez: | Bunt foul, Bunt foul, Pickoff attempt, Rodriguez struck out bunting foul. |
| Kazuo Matsui: | Ball, Ball, Matsui tripled to right, Erstad scored. |
| Miguel Tejada: | Ball, Strike (foul tip), Ball, Ball, Strike swinging, Tejada struck out swinging. |
| End of Inning (2 Runs, 3 Hits, 0 Errors) | |
| Cubs 5th | |
| Wandy Rodriguez pitching: | |
| Kosuke Fukudome: | Ball, Fukudome flied out to right. |
| Henry Blanco: | Strike looking, Blanco flied out to deep left. |
| Rich Harden: | Foul, Foul, Foul, Harden struck out swinging. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
| Astros 6th | |
| Rich Harden pitching: | |
| Hunter Pence: | Ball, Ball, Strike swinging, Pence singled to center. |
| Carlos N. Lee: | Ball, Lee popped out to second. |
| Geoff Blum: | Pickoff attempt, Blum homered to right, Pence scored. |
| Ty Wigginton: | Ball, Ball, Foul, Wigginton grounded out to shortstop. |
| Darin Erstad: | Foul, Foul, Erstad singled to left center. |
| Humberto Quintero: | Ball, Ball, Ball, Strike looking, Quintero walked, Erstad to second |
| Mark Loretta hit for Wandy Rodriguez. | |
| Bob Howry relieved Rich Harden. | |
| Mark Loretta: | Strike looking, Loretta grounded into fielder's choice to shortstop, Quintero out at second. |
| End of Inning (2 Runs, 3 Hits, 0 Errors) | |
| Cubs 6th | |
| Chris Sampson pitching: | |
| Alfonso Soriano: | Strike swinging, Soriano doubled to left. |
| Ryan Theriot: | Strike looking, Ball, Theriot singled to center, Soriano to third. |
| Derrek Lee: | Foul, Ball, Lee flied out to right. |
| Aramis Ramirez: | Pickoff attempt, Ramirez grounded into double play shortstop to second to first, Theriot out at second. |
| End of Inning (0 Runs, 2 Hits, 0 Errors) | |
| Astros 7th | |
| Bob Howry pitching: | |
| Kazuo Matsui: | Strike looking, Matsui singled to right. |
| Miguel Tejada: | Strike looking, Tejada grounded out to pitcher, Matsui to second. |
| Hunter Pence: | Strike swinging, Ball, Strike looking, Foul, Ball, Ball, Pence struck out swinging. |
| Carlos N. Lee: | Lee homered to left center, Matsui scored. |
| Geoff Blum: | Foul, Strike swinging, Blum struck out swinging. |
| End of Inning (2 Runs, 2 Hits, 0 Errors) | |
| Cubs 7th | |
| Chris Sampson pitching: | |
| Reed Johnson: | Strike looking, Strike swinging, Ball, Ball, Ball, Johnson singled to center. |
| Mark DeRosa: | Strike looking, Strike looking, Pickoff attempt, Ball, Ball, DeRosa doubled to deep right, Johnson to third. |
| Kosuke Fukudome: | Fukudome hit sacrifice fly to center, Johnson scored |
| Daryle Ward hit for Henry Blanco. | |
| Daryle Ward: | Intentional ball, Intentional ball, Intentional ball, Ward intentionally walked |
| Jason Marquis ran for Daryle Ward | |
| Mike Fontenot hit for Bob Howry. | |
| Mike Fontenot: | Wesley Wright relieved Chris Sampson, Geovany Soto hit for Mike Fontenot. |
| Geovany Soto: | Ball, Strike looking, Ball, Foul, Foul, Foul, Soto struck out swinging. |
| Doug Brocail relieved Wesley Wright | |
| Lance Berkman at first. | |
| Alfonso Soriano: | Foul, Strike looking, Ball, Soriano homered to left center, DeRosa and Marquis scored. |
| Ryan Theriot: | Ball, Ball, Strike looking, Ball, Theriot walked. |
| Derrek Lee: | Ball, Strike (foul tip), Ball, Theriot stole second, Ball, Lee singled softly to right, Theriot scored. |
| Aramis Ramirez: | Ball, Ball, Foul, Ball, Strike looking, Ramirez popped out to second. |
| End of Inning (5 Runs, 4 Hits, 0 Errors) | |
| Astros 8th | |
| Kerry Wood pitching: | |
| Ty Wigginton: | Foul, Wigginton flied out to center. |
| Darin Erstad: | Strike looking, Erstad singled to center. |
| Humberto Quintero: | Quintero flied out to deep right. |
| Lance Berkman: | Ball, Berkman lined out to center. |
| End of Inning (0 Runs, 1 Hit, 0 Errors) | |
| Cubs 8th | |
| Doug Brocail pitching: | |
| Reed Johnson: | Strike looking, Ball, Strike looking, Johnson struck out swinging. |
| Mark DeRosa: | Foul, DeRosa grounded out to shortstop. |
| Kosuke Fukudome: | Strike looking, Ball, Strike looking, Fukudome struck out looking. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
| Astros 9th | |
| Carlos Marmol pitching: | |
| Kazuo Matsui: | Strike looking, Ball, Ball, Foul, Foul, Matsui popped out to shortstop. |
| Miguel Tejada: | Strike looking, Ball, Foul, Foul, Tejada popped out to first. |
| Hunter Pence: | Foul, Strike looking, Ball, Pence struck out swinging. |
| End of Inning (0 Runs, 0 Hits, 0 Errors) | |
