Griffey hit two homers and Felipe Lopez doubled home the go-ahead run with two outs in the ninth inning as the Reds remained unbeaten under interim manager Jerry Narron with a 5-4 victory over the Cleveland Indians on Friday night.
"Any time you win it is fun, but Jerry's a good guy and let's keep it going," said Griffey, who went 3-for-4 and has 23 RBI in the past 26 games with a .347 (35-for-101) average.
The Reds are 3-0 since Narron replaced Dave Miley, who was fired. Cincinnati snapped an eight-game road losing streak and is 7-6 in interleague play.
Jose Hernandez hit two homers for Cleveland, which lost its fourth straight and fell to 13-3 in interleague play after winning nine straight against NL teams.
"Offensively, we sure have to do a better job of taking advantage of opportunities," said Cleveland manager Eric Wedge, who would not compare the Indians' play of late to a streaky August 2004. Ten months ago, Cleveland won 10 of 11 to move within one game of first place -- then dropped nine straight to fall out of contention.
Wily Mo Pena singled to open the ninth against Bob Howry (4-2) and was sacrificed to second. After Edwin Encarnacion struck out, Lopez hit a 1-1 pitch the opposite way off the left-field wall to score Pena.
"I just tried to get my pitch to hit," said Lopez, who went 2-for-4 and leads all NL shortstops with 44 RBI. "I thought they might pitch around me with nobody on first, but he threw a fastball outside and I went with it."
Griffey tied the score 4-4 with a one-out shot into the right-field stands in the eighth for his 14th homer this season and 515th of his career. It was his first multihomer game this year and 51st of his career.
"I'm not surprised at what he's doing," Narron said. "His slow start was a matter of him getting his legs. He hits with his legs and he wasn't able to do that earlier."
Griffey delivered on a 3-2 pitch from Scott Sauerbeck to snap an 0-for-12 career streak with four strikeouts against the left-hander.
"You face a guy enough and you're going to get one," Griffey said. "He's a tough lefty who throws from a lot of different angles."
Sauerbeck said he had no idea he had been that successful against Griffey.
"He just beat me," Sauerbeck said. "I don't even think it was a strike, but he's a Hall of Famer and he got it."
Griffey and Joe Randa hit consecutive homers to open the Reds' second off Scott Elarton. Griffey sent a drive the opposite way into the left-field bleachers on the first pitch. Randa followed with his 12th homer for a 2-1 lead.
Hernandez put the Indians ahead 3-2 with his second homer leading off the bottom half against Eric Milton. He opened the fourth with another homer for a 4-3 lead. It was his eighth career multihomer game and first since May 7, 2004, at Pittsburgh when he was with Los Angeles.
Cleveland took a 2-0 lead in the first. Victor Martinez had an RBI single and Ronnie Belliard followed with a run-scoring double. Martinez tried to score from first and was out by 20 feet to end the inning.
A sacrifice fly by Sean Casey in the Reds' third tied the score at 3.
Elarton allowed three runs over six innings, striking out a season-high seven.
Milton, 0-4 in six starts since May 28, allowed four runs over six innings -- the 11th time in 16 starts he has given up four or more this season. He has given up 27 homers, the most in majors.
- Cleveland leads the all-time interleague series between the Ohio teams 21-16.
- 3B Aaron Boone returned to the Cleveland lineup after missing two games with strep throat. He said he lost eight to 10 pounds because he had trouble swallowing and did not eat for a few days.
- Griffey is 16th on the all-time homer list, six behind Hall of Famers Ted Williams and Willie McCovey.
- Hernandez had gone 88 at-bats since his last homer, April 16.
- Cincinnati is 7-24 on the road.