CINCINNATI -- Lyle Overbay does not know why he is so good in Cincinnati.
Overbay hit two home runs, including a grand slam, and drove in a career-high six runs as the Milwaukee Brewers pounded Brandon Claussen and beat the Cincinnati Reds 11-7 Saturday.
Carlos Lee also homered and drove in three runs to take over the National League lead with 82 RBI, one more than Chicago's Derrek Lee.
Overbay extended his hitting streak to seven games with his second career multihomer game -- both this season in Cincinnati. He is 7-for-11 (.636) with four home runs in his career against Claussen.
"I can't explain it," Overbay said. "I don't know what it is. The Cubs do the same thing to me, but they get me out. I can't explain that, either.
"It's funny. I was sitting in St. Louis thinking about how I was looking forward to coming to Cincinnati."
Claussen, who tied a club record by allowing five home runs in his last game, gave up three homers Saturday. He allowed six hits and nine runs with four strikeouts in 3 2/3 innings.
Claussen (4-8) also walked three and hit a batter, all in the fourth inning. He has given up eight homers in 7 1/3 innings over his last two starts.
"I would love to talk," he said. "I'm just a little upset. I'm so much better than that performance. I'm so much better than the performance before that. I take a lot of pride in my job, and my last two outings are hard to swallow."
Victor Santos (3-10) struggled through five innings to earn his first win since May 24. He allowed nine hits and five runs with three walks and three strikeouts.
Overbay's two-run homer gave Milwaukee a 3-0 lead in the first inning. Carlos Lee made it 4-0 with a two-out solo homer in the third, his 24th homer of the season.
Ryan Freel scored from second on Sean Casey's bloop single to right-center field in the third, but the Brewers took advantage of Claussen's control problems to break open the game in the fourth.
"We'd like to see him more aggressive early in the count and throw quality strikes," Reds interim manager Jerry Narron said. "When you're facing the middle of the order, you can't give them cookies."
Three walks and a hit batsman scored one run and loaded the bases, setting up Overbay's second career grand slam, a 407-foot shot into the right-field seats on a 3-1 pitch. He has 14 homers this season, two short of the career-high 16 he hit last season.
"The grand slam, he had to come in," Overbay said. "I was sitting dead-red. The first home run actually wasn't a bad pitch. For some reason, I dropped my hands and hit it."
Overbay hit his other grand slam against the Reds, connecting off Jimmy Haynes on May 4, 2004. His other two-homer game came in Cincinnati on April 29.
Claussen threw 36 of his 90 pitches in the fourth inning.
"Early in the game, we wanted to give him every chance to pitch out of it," Narron said. "Fourth inning, you don't want to be going to the bullpen. You've got to give a kid the chance to be successful."
The Reds received consecutive run-scoring singles by Felipe Lopez and Casey, and Adam Dunn's two-run double to left in the fifth, but Lee responded with a two-run homer, his 24th, in the sixth.
Dunn drove in another run with a single and Austin Kearns hit a sacrifice fly in the seventh.
"We had an eight-run lead, but I never feel safe in this place -- not with the offense they've got," Brewers manager Ned Yost said. "Things happen here in a hurry."
The Reds traded 3B Joe Randa to San Diego for two minor-league right-handers and called up 3B Edwin Encarnacion from Triple-A Louisville. ... OF Ken Griffey Jr. went 0-for-5, snapping his streak of 25 consecutive games reaching base. ... Geoff Jenkins singled in the fifth to extend his career-best hitting streak to 16 games, Milwaukee's longest of the season. ... The game lasted 3 hours, 34 minutes, Cincinnati's longest nine-inning game of the season. ... Claussen is 0-4 over five starts since his last win on June 21. ... Santos was 0-6 in his nine starts between wins. ... The Reds blew their seventh opportunity for their first four-game win streak of the season. ... The crowd of 36,320 included a season-high walkup of 10,185 on Sean Casey Figurine Night.