SEATTLE -- Nothing was routine in this early April game for Jarrod Washburn.
"I'd be lying if I said I didn't want to win today more than any other of my starts," Washburn said.
Signed to a $37 million, four-year contract, Washburn allowed two runs and six hits in seven innings, struck out seven and walked none.
"He did a lot of the stuff we've seen him do," Angels manager Mike Scioscia said. "He shut the door when he had to."
Weaver, who left the Los Angeles Dodgers to sign an $8,325,000, one-year contract with the Angels, gave up five runs and nine hits in 6 1/3 innings.
"I made it tough on myself and the defense. The leadoff guy was on pretty much every inning," Weaver said.
Orlando Cabrera's two-run homer in the eighth off Julio Mateo pulled the Angels to 5-4, but Brendan Donnelly threw a run-scoring wild pitch in the bottom half.
George Sherrill got three outs for his first save in 52 career appearances, but not without an all-too-typical Seattle bullpen adventure. Sherrill allowed a walk and a single before he got Chone Figgins to pop out to end the game.
Sherrill closed because Eddie Guardado threw 41 pitches while allowing three runs Tuesday. Nine of the Angels' 17 runs in the series came against relievers.
"Real shallow breaths in the ninth," Seattle manager Mike Hargrove said. "But at least I was still breathing."
Richie Sexson and Raul Ibanez each drove in two runs for Seattle, which won twice in the opening three-game series.
"It shows people what kind of team we may have," Washburn said, mindful Seattle is coming off consecutive 90-loss seasons. "We have high hopes for ourselves."
Washburn retired 10 straight following Garret Anderson's first-inning single.
"He was definitely fired up those first few innings, the way he was throwing the ball," the Angels' Tim Salmon said.
Sexson's two-run double in the first and Jose Lopez's RBI single in the second built a 3-0 lead.
Salmon, the designated hitter after pinch-hit roles in each of the first two games, ended his buddy's hitless streak when he homered on the first pitch of the fifth inning. It was his second home run in two games -- and second since April 2004.
Salmon also doubled off Washburn to create a two-on, no-out jam in the seventh with Seattle ahead 4-1. Washburn shook his head at his friend, who responded with a shoulder shrug.
Washburn allowed an RBI grounder to Darin Erstad, retired Edgardo Alfonzo a grounder and struck out Casey Kotchman on an 80 mph changeup.
Washburn punctuated his 100th and final pitch with a right uppercut punch into the air. He then slapped gloves with catcher Kenji Johjima on his way off the field.
"I used a few things against a few guys that I had put in the back of my mind from watching them previously," Washburn said. "I was expecting to have quite a few jitters. But I was able to stay calm."
Mateo hit Guerrero in the front of the batting helmet with a pitch in the eighth, and Guerrero landed on his back. Scioscia and the team trainer rushed onto the field to check on Guerrero, but he immediately bounced up and went to first base. Weaver hit Sexson on the left elbow with a pitch in the third inning and Washburn buzzed Guerrero near the ribs with a first pitch in the fourth. There were five hit batters in the series, but Scioscia brushed off the sequences as a non-issue. He said Guerrero is fine ... Washburn's seven strikeouts equaled his season high from 2005. ... Wednesday was the first time Salmon homered in consecutive games since June 15-16, 2002, facing the Dodgers. ... Johjima had a single, walk and run scored after homering in each of his first two games. ... The Angels committed six errors in the series. They were third in majors last season, committing 87 in 162 games.