The right-hander gave up four hits in eight innnings in his first game back from the disabled list Thursday, and Carlos Guillen homered twice and drove in five runs to help the Tigers rout the Los Angeles Angels 12-0.
Magglio Ordonez had four hits and three RBI to take over the major league lead with 45, two more than the Yankees' Alex Rodriguez. Gary Sheffield added a solo home run in the third as Detroit won for the fifth time in six games.
Eight of the Tigers' 13 hits were for extra bases. They lead the American League with 181 extra-base hits.
"It was a good, fun game for everyone," said Bonderman (3-0), who pitched for the first time since May 8 after missing two starts with a blister on his right middle finger.
Bonderman walked five and struck out six to win for the third time in as many starts.
Unlike his first five starts, all no-decisions, the Detroit offense came alive against the Angels.
Bonderman allowed his first three batters to reach base but worked out of the jam by starting a double play and inducing a flyout. Guillen staked Bonderman to a four-run lead when he extended his hitting streak to eight games with a three-run homer in the bottom of the inning.
"I got out of that first inning and the boys put up four," Bonderman said. "After that I just wanted to keep going."
Los Angeles also got runners to third in the third and fourth innings but Bonderman escaped both times. Detroit manager Jim Leyland said he thought about keeping his starter in for the ninth but opted not to risk the blister returning.
"You have to tip your hat to him," said Gary Matthews Jr., who went 0-for-3 against Bonderman. "He pitched very well and got the lead early.
"When that happens, it's advantage to the pitcher."
Wilfredo Ledezma pitched a perfect ninth for the Tigers' first shutout of the season.
Ordonez drove in two runs with his second double of the game in the fourth inning to chase Ervin Santana (3-6). Ordonez has driven in 39 runs in his past 32 games, and had his 15th four-hit game. It was his first since May 11, 2004, against Baltimore while a member of the White Sox.
"My swing is really good right now and I'm being more patient and I don't try to do too much," he said, adding he hasn't felt this good at the plate since he joined the Tigers before the 2005 season.
"I'm patient and I wait for my pitch."
His manager is content to sit back and watch the outfielder work.
"I don't say anything to him. I just let him go," Leyland said. "He's hitting the ball all over.
"I don't think I've seen anything quite like it."
Santana gave up eight runs and seven hits in 3 2/3 innings and lost for the fourth time in his past seven starts. The right-hander is winless in five road starts this season.
"He took a half step backward today," manager Mike Scioscia said. "He had no command and he paid the price against a great hitting team like the Tigers.
"His issue is not home or away. His issue is the location of his fastball."
Guillen hit a two-run shot, his third homer in two games, in the sixth off Chris Bootcheck. It was his first two-homer game since Sept. 12 against Texas.
- Detroit has won six of its past seven series and is 5-1 on its current homestand.
- Ordonez had his team-best 17th multiple-RBI game.
- Angels shortstop Orlando Cabrera extended his hitting streak to 14 games with a first-inning single.
- Rick Comley, coach of Michigan State's NCAA men's hockey champions, threw out the ceremonial first pitch.