Earlier, the Yankees defeated Baltimore 8-7 in the completion of a game suspended on June 28 by rain. Play resumed in the eighth inning with the Yankees up 8-6, and closer Mariano Rivera gave up a run in a harrowing ninth before earning his 16th save.
That game officially occurred last month, so after it was over the Orioles could resume their quest to win a seventh straight at home. Guthrie helped make it happen, outpitching Orioles nemesis Andy Pettitte with a gritty performance.
"This guy is a great pitcher," Pettitte said. "He won the pitchers duel. I wasn't able to do it tonight."
Guthrie (7-3) gave up six hits, struck out four and walked three. He has won his past three starts, allowing only four earned runs in 19 innings.
"I know Guthrie and what kind of person he is. When I saw him in the minor leagues, he was not a minor league pitcher," Orioles interim manager Dave Trembley said. "He was a major league pitcher because he had stuff and he had poise. He's showed that ever since he walked into the clubhouse (during spring training) in Fort Lauderdale."
Perhaps that's why Guthrie could deal with facing Rodriguez, seeking a milestone homer to mark his 32nd birthday.
Rodriguez grounded out in his only at-bat after the suspended game was resumed, then went 0-for-2 with two walks and two routine fly balls.
"You don't want to be the guy to give it up, but at the same time you want to attack him," Guthrie said. "He's so hot right now, you have to execute pitches. If not, he can do damage."
Each time Rodriguez stepped to the plate, flashbulbs popped from within the crowd of 47,952.
"I felt like I was pitching to Barry Bonds," Guthrie said.
Chad Bradford, the fourth Baltimore reliever, worked the ninth for his first save.
Pettitte (6-7) permitted three runs and eight hits in eight innings. He was 20-5 against the Orioles in his career, including 12-3 at Baltimore. The left-hander's 12 wins at Camden Yards are five more than any other visiting pitcher.
"I gave us a chance. I hate that we weren't able to win," Pettitte said.
Baltimore wasted three singles in the bottom half, but took a 3-1 lead in the third when Hernandez hit a two-run, two-out single and Jay Gibbons followed with an RBI single.
"The biggest inning was the fifth," Guthrie said. "Jeter is probably the toughest hitter that I face, so to get that out was huge. Then I got a good ground ball there."
New York pulled within a run in the sixth when Rodriguez drew a leadoff walk and scored on a single by Robinson Cano.
New York went 1-for-7 with runners in scoring position after going 0-for-12 in a 7-0 loss to Kansas City on Thursday night.
"We had men on base with two out and couldn't bring them in," Yankees manager Joe Torre said. "We're having good at-bats. We're just not getting hits."
In the suspended game, Mike Myers (2-0) got the last out in the Baltimore seventh and returned Friday to face two batters in the eighth before Rivera entered and got an inning-ending double play.
In the ninth, Rivera yielded a pinch-hit RBI single to Hernandez but got the final out with runners on the corners.
Parrish (2-1), who gave up a two-run single to Jeter immediately before rain halted play for a month, took the loss.
- The Orioles activated SS Miguel Tejada (wrist) from the 15-day disabled list. He endured a hitless night.
- The Yankees sent struggling LHP Kei Igawa to Triple-A Scranton and recalled INF Chris Basak from the same club.
- Orioles umpire attendant Ernie Tyler served in his 3,679th straight home game, but will end the streak Saturday to go to Cooperstown for the Hall of Fame induction of Cal Ripken.