Ramirez swung away for a key single, setting up Orlando Cabrera's fourth hit that drove in the go-ahead run in the 12th inning and the White Sox beat Cleveland 6-3 on Monday night, handing the Indians their ninth loss in 10 games.
"He went from two seconds from being in (Triple-A) Charlotte to being a hero," Guillen said of Ramirez. "He did that on his own. I was surprised but (bench coach) Joey Cora told me he's been working on that in batting practice."
Jenks allowed two singles, then got Jhonny Peralta to hit into a double play and struck out Franklin Gutierrez to become the second-fastest reliever to notch 100 career saves, doing so in 187 games. Kazuhiro Sasaki did it in 160 for Seattle in 2000-02.
"It's an honor to get there," said Jenks, who then joked: "I think I only have 500 more to catch (Trevor) Hoffman".
San Diego's Hoffman is the all-time leader with 533 saves.
The White Sox won for the 10th time in 12 games and moved 5½ games ahead of the third-place Indians in the AL Central.
Nick Swisher opened the 12th with a single off right-hander Scott Elarton (0-1). Pinch-runner DeWayne Wise went to third on Ramirez's single through the right side and scored on another single to right by Cabrera, who was then caught in a rundown trying for second.
After A.J. Pierzynski was intentionally walked, Ramirez scored on a groundout by Carlos Quentin and Jermaine Dye got another intentional walk. Brian Anderson then slapped an RBI double just inside the first-base line to make it 6-3.
Elarton, called up from Triple-A Buffalo on Saturday, was making his first relief appearance in the majors since Sept. 6, 2003, with Colorado. He had started 154 times in 155 outings since 1999.
"It's not the way I had it written up," Elarton said. "I just didn't make pitches -- though I was thinking dead bunt with that second hitter and threw it up and away, never thinking for a moment he'd be slashing there."
David Dellucci and Jhonny Peralta hit solo homers in the first and fifth innings for Cleveland, but the Indians' offense continued to struggle. Cleveland came in last in the AL with a .232 average, and stranded 13 baserunners while going 1-for-13 with runners in scoring position. The Indians are 2-for-25 with RISP in their last two games -- both extra-inning losses.
"Things are not going our way right now," Indians manager Eric Wedge said. "That's why we play six months and we've got four-plus to go.
"We'll come out of this stronger. We have to be competitive in this division."
The White Sox, next-to-last in hitting with a .243 mark entering the game, weren't much better until their winning rally.
Dellucci's fifth homer in the bottom half tied it and the Indians copied Chicago's early effort in the third when their first three batters all reached safely, but only one run scored on a single by Victor Martinez to make it 2-1.
Peralta hit his 10th home run with one out in the fifth and Thome hit his 10th -- and fifth of the year against his former team -- in the sixth to get Chicago within 3-2. It was Thome's 517th career home run, three behind Oakland's Frank Thomas for 18th all-time.
Byrd gave up 10 hits and three runs over 6 2/3 innings.
"I pitched OK, not great," Byrd said. "There's no use denying it by just talking positive. We're losing. We don't like it, especially with a chance to make up some ground against the White Sox."
Chicago had only two hits in its previous 17 at-bats with runners in scoring position until Pierzynski singled to center off reliever Rafael Perez with two outs in the seventh to tie it at 3.
White Sox starter Javier Vazquez gave up three runs and nine hits over six innings.
- Last week, Indians GM Mark Shapiro said he would try "incremental moves" to improve the team. Monday, he signed OF Todd Linden and INF Jorge Velandia to minor-league contracts and assigned them to Triple-A Buffalo.
- Dellucci was 5-for-43 (.116) before his home run.
- White Sox 1B Paul Konerko went 0-for-6 in his first game after missing three with a sore right hand.
- Chicago OF Carlos Quentin went 2-for-6 and is batting .353 (24-for-68) with six home runs and 20 RBI in his past 18 games.