Pinch-hitter Ramon Hernandez walked with one out and pinch-runner Brandon Phillips moved to second on pinch-hitter Edgar Renteria's short groundout to Spence. Joey Votto was intentionally walked and Bruce responded with a drive into the seats in right for his 24th homer.
Bruce also doubled in a run in the fourth for Cincinnati, which has won three straight games. Bill Bray (3-2) got the final out of the eighth, and Francisco Cordero pitched the ninth for his 23rd save.
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Mat Latos pitched seven effective innings for San Diego, but had to settle for a no-decision. The right-hander gave up two runs and four hits, struck out five and walked one.
Bronson Arroyo made a pair of errors, but pitched six effective innings for Cincinnati. The soft-tossing right-hander allowed two runs, one earned, and six hits. He also struck out six, walked two and hit a batter.
The Padres grabbed the lead in the first, taking advantage of Arroyo's unusual error. Arroyo, last year's Gold Glove pitcher, missed first base and turned his right ankle on Jason Bartlett's one-out grounder to first baseman Joey Votto.
Hundley, reinstated from the 15-day disabled list before the game, led off the second with a 406-foot home run to left-center field, his fourth of the season and first since April 17 at Houston.
Hundley was placed on the DL on July 8 with a right elbow strain that required arthroscopic surgery.
- Reds SS Zack Cozart spent part of his 26th birthday on Friday undergoing Tommy John surgery on his left [non-throwing] elbow. He is expected to resume baseball activities in December and be 100 percent for spring training.
- Cairo's seventh-inning triple was the 1,000th hit of his career.
- The Padres optioned C Luis Martinez to Triple-A Tucson and sent RHP Ernesto Frieri to Tucson for a 30-day rehabilitation assignment.
- RHP Tim Stauffer, San Diego's starter on Saturday, is 2-0 with a 1.76 ERA in three games, two starts, at Great American Ball Park.
- RHP Homer Bailey, Cincinnati's scheduled starter, allowed five runs and six hits in three innings in a 10-7 loss to Colorado on Monday.