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"He was making some mistakes, falling behind hitters and walked three guys," Martinez said. "I knew he had to give me something to hit. That was my mindset. I was going to be aggressive and go for it."
Matt Downs also homered and Justin Maxwell drove in a run for the Astros, who dropped 13 of their previous 17 games -- including a 10-0 loss Wednesday night when Giants ace Matt Cain pitched a perfect game.
Jose Altuve had two hits and a walk. The young second baseman ranks among the major league leaders in average and hits.
"We had to bounce back today and we had to get runs early," Downs said. "Altuve set the tone early and got it over with. That pumped all of us up."
"He was able to give us a quality start," manager Brad Mills said. "That two-out home run was a little bit of a hiccup but, it's always nice to get at least one game in the series."
Zito (5-4) lasted five innings, allowing five runs and five hits. He walked three and struck out three in losing two straight decisions for the first time this season.
"I screwed up making pitches and things happened after that," Zito said.
After tossing 8 1/3 shutout innings against the Chicago Cubs on June 3, Zito has allowed nine runs and 14 hits in his last 11 innings.
"He was throwing the ball well," Giants manager Bruce Bochy said. "He allowed a solo home run and then got out of sync."
Downs gave the Astros a 1-0 lead with his fourth homer of the season with two outs in the second.
Zito walked Altuve, Brian Bixler and Jed Lowrie in succession to open the third, setting up Martinez's slam that traveled halfway up the left-field bleachers. The left-hander has allowed four home runs in his past two games after giving up four in his previous eight.
"I was relieved I was able to come through for the team," Martinez said. "We kept telling each other to attack them early and score early."
Maxwell's two-out single in the eighth gave the Astros a 6-3 lead.
Belt's third home run in three days put the Giants on the scoreboard in the fourth. His two-run shot cleared the right-field bleachers and landed in McCovey Cove.
Sanchez hit his sacrifice fly in the sixth.
|Houston's J.D. Martinez smacks his first career grand slam in the third inning. (Getty Images)|
|Players of the Game|
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|Jose Altuve, 2B||4||1||2||0||1||0||1||.324|
|Brian Bixler, RF||2||2||1||0||2||0||0||.261|
|Fernando Rodriguez, P||0||0||0||0||0||0||0||.000|
|Brett Myers, P||0||0||0||0||0||0||0||.000|
|Jed Lowrie, SS||3||1||0||0||1||0||2||.275|
|J.D. Martinez, LF||4||1||1||4||0||0||3||.227|
|Justin Maxwell, CF||4||0||1||1||0||1||0||.230|
|Chris Johnson, 3B||4||0||1||0||0||0||1||.279|
|Matt Downs, 1B||4||1||1||1||0||0||1||.171|
|Jason Castro, C||4||0||0||0||0||3||0||.250|
|Wandy Rodriguez, P||2||0||0||0||0||0||0||.000|
|a- Jordan Schafer, PH||1||0||0||0||0||0||0||.241|
|Wesley Wright, P||0||0||0||0||0||0||0||.000|
|Brian Bogusevic, RF||1||0||1||0||0||0||0||.229|
|a-grounded out for Rodriguez in the 7th|
|HR - J.D. Martinez (7, Zito), Matt Downs (4, Zito)|
|RBI - J.D. Martinez 4 (37), Justin Maxwell (19), Matt Downs (7)|
|2-OUT RBI - Justin Maxwell (6), Matt Downs (4)|
|Team LOB - 4|
|DP - Altuve-Lowrie-Downs, Downs-Lowrie-Myers|
|Wandy Rodriguez (W,6-4)||6||6||3||3||2||3||1||3.35|
|Wesley Wright (H,8)||1||0||0||0||0||0||0||4.26|
|Fernando Rodriguez (H,6)||1||0||0||0||0||1||0||4.56|
|Brett Myers (S,16)||1||1||0||0||0||0||0||1.99|
|Pitches-Strikes - Wandy Rodriguez 97-58, Wesley Wright 7-6, Fernando Rodriguez 15-13, Brett Myers 8-5|
|Ground Balls-Fly Balls - Wandy Rodriguez 8-6, Wesley Wright 2-1, Fernando Rodriguez 2-0, Brett Myers 1-1|
|Batters Faced - Wandy Rodriguez 25, Wesley Wright 3, Fernando Rodriguez 3, Brett Myers 3|
|San Francisco Giants|
|Gregor Blanco, RF||3||0||0||0||1||1||0||.274|
|Ryan Theriot, 2B||4||0||1||0||0||0||1||.260|
|Melky Cabrera, LF||3||0||0||0||1||1||1||.363|
|Angel Pagan, CF||4||1||1||0||0||2||2||.314|
|Pablo Sandoval, 3B||4||0||2||0||0||0||2||.316|
|Hector Sanchez, C||3||1||1||1||0||0||1||.274|
|Brandon Belt, 1B||4||1||1||2||0||0||1||.238|
|Joaquin Arias, SS||3||0||1||0||0||0||0||.239|
|Barry Zito, P||1||0||0||0||0||0||1||.087|
|a- Emmanuel Burriss, PH||1||0||0||0||0||0||0||.211|
|Shane Loux, P||0||0||0||0||0||0||0||.000|
|b- Nate Schierholtz, PH||1||0||0||0||0||0||0||.259|
|Clay Hensley, P||0||0||0||0||0||0||0||.000|
|Jeremy Affeldt, P||0||0||0||0||0||0||0||.000|
|a-grounded out for Zito in the 5th|
|b-grounded out for Loux in the 7th|
|2B - Ryan Theriot (5, Rodriguez)|
|HR - Brandon Belt (3, Rodriguez)|
|SF - Hector Sanchez (3)|
|RBI - Hector Sanchez (18), Brandon Belt 2 (24)|
|2-OUT RBI - Brandon Belt 2 (8)|
|SB - Gregor Blanco (8, 2nd base off Rodriguez/Castro)|
|Team LOB - 4|
|DP - Sandoval-Theriot, Arias-Theriot-Belt|
|San Francisco Giants|
|Barry Zito (L,5-4)||5||5||5||5||3||3||2||3.61|
|Pitches-Strikes - Barry Zito 77-47, Shane Loux 19-10, Clay Hensley 20-12, Jeremy Affeldt 8-6|
|Ground Balls-Fly Balls - Barry Zito 5-6, Shane Loux 5-0, Clay Hensley 2-1, Jeremy Affeldt 1-1|
|Batters Faced - Barry Zito 22, Shane Loux 6, Clay Hensley 5, Jeremy Affeldt 4|
|Attendance - 41662|
|Game Time - 2:31|
|Temperature - 64|
|Umpires - Home - Mike Muchlinski, First Base - Angel Campos, Second Base - Brian Runge, Third Base - Ted Barrett|