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Ellsbury singled with one out against Brandon Gomes (0-1), stole second and advanced on catcher Jose Lobaton's throwing error when the ball deflected off shortstop Yunel Escobar's glove and into short right field. Victorino then hit a hard grounder into the unusual infield configuration that second baseman Ben Zobrist made a diving stop on to his right, but was unable to make a throw home.
"That's the goal right there," a smiling Victorino said. "Just put the ball in play. I've been in that spot before."
Ellsbury knew he'd score easily once the ball got past the pitcher.
"When I saw him dive, I knew I was going to get in," he said. "It's probably got to be hit right at someone to have them make a throw."
David Ross had a solo homer for Boston, which snapped a two-game losing streak.
Red Sox manager John Farrell said he had the "contact play on" in the 10th, where Ellsbury was breaking on any ball hit on the ground.
"We felt like we had the combination we could take advantage of," he said.
Rays manager Joe Maddon felt it was just hit in the wrong spot for his defense.
"The ball was perfect," he said. "You bisect two guys on the same side of the infield and then furthermore, hit it at the right speed. It's just very unfortunate for us. But something we work on. They beat us."
Junichi Tazawa (2-0) pitched one inning for the win, getting out of a jam after giving up a leadoff double to Jose Molina, who was lifted for a pinch runner. Lobaton entered in the bottom of the 10th.
The Rays went 0 for 11 with runners in scoring position.
"In my career, I've noticed early in the season a lot of teams struggle with that," Tampa Bay's Shelley Duncan said of his team's clutch hitting woes. "Sometimes guys press a little more earlier than they do in the middle of the year."
Boston's Koji Uehara escaped a ninth-inning jam after closer Joel Hanrahan had his second poor outing this week. Gomes then got Stephen Drew to line out to center field with a pair of runners on, sending it to extra innings.
Hanrahan, who gave up five runs in the ninth of a loss to Baltimore on Wednesday, opened the ninth by walking Evan Longoria and Zobrist. Uehara then struck out pinch-hitter James Loney looking before retiring the next two hitters.
Lester held the Rays to one run on five hits, walked one and struck out five to move into sixth place ahead of Luis Tiant on the club's career strikeout list with 1,078. Tiant had 1,075 from 1971-78.
"We had to make a couple of adjustments where I had to get the ball down," Lester said. "You have those days where you've getting the ball up."
Price, coming off a miserable start when he allowed a career-worst eight runs last Sunday against Cleveland, pitched six innings, allowing just the solo homer to Ross and three other hits while striking out eight and walking four.
Price mostly mixed a sharp cutter with a fastball and an occasional curve to make the Red Sox hitters look as if they were guessing most of the time.
"I felt a lot better. It started with my bullpen last week," he said. "Just going to continue to get my work in. Like I said before, six innings over here just isn't enough. That's a very good team and Lester threw the ball extremely well today."
With the Red Sox trailing 1-0 in the fifth, Ross belted a homer out of Fenway Park, sending a hanging change-up over the Green Monster seats. Before that, Boston had just one infield hit -- a bouncer to deep short that Victorino barely beat out.
The Rays jumped ahead 1-0 in the third, but Lester stranded Sean Rodriguez on third base after he reached with no outs. Desmond Jennings singled and scored when Rodriguez's doubled down the left field line didn't carom very far and stayed deep in the corner. He advanced on a wild pitch.
|Dustin Pedroia welcomes Jacoby Ellsbury home with the winning run as the Red Sox edge Tampa Bay 2-1. (USATSI)|
|Players of the Game|
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|Tampa Bay Rays|
|Desmond Jennings, CF||5||1||1||0||0||1||1||.243|
|Sean Rodriguez, 1B||2||0||1||1||1||1||0||.167|
|a- Sam Fuld, PH-RF||2||0||0||0||0||0||1||.100|
|Evan Longoria, 3B||3||0||0||0||1||2||1||.313|
|Ben Zobrist, RF-2B||3||0||0||0||1||0||2||.333|
|Shelley Duncan, DH||3||0||0||0||0||0||1||.200|
|b- James Loney, PH-DH||1||0||0||0||0||1||2||.208|
|Yunel Escobar, SS||4||0||1||0||0||1||2||.118|
|Ryan Roberts, 2B-1B||4||0||1||0||0||0||3||.278|
|Jose Molina, C||4||0||2||0||0||0||0||.294|
|Kelly Johnson, PR||0||0||0||0||0||0||0||.182|
|Jose Lobaton, C||0||0||0||0||0||0||0||.231|
|Matt Joyce, LF||4||0||0||0||0||1||3||.148|
|a-fouled out for S. Rodriguez in the 8th|
|b-struck out for Duncan in the 9th|
|2B - Sean Rodriguez (1, Lester), Jose Molina (1, Tazawa)|
|RBI - Sean Rodriguez (2)|
|SB - Sean Rodriguez (1, 2nd base off Lester/Ross)|
|Team LOB - 7|
|E - Jose Lobaton (1, Throwing)|
|Tampa Bay Rays|
|Brandon Gomes (L,0-1)||0.2||2||1||0||1||1||0||1.93|
|WP - Brandon Gomes (1)|
|Pitches-Strikes - David Price 106-69, Jake McGee 13-11, Joel Peralta 11-8, Kyle Farnsworth 4-3, Cesar Ramos 2-1, Brandon Gomes 24-13|
|Ground Balls-Fly Balls - David Price 4-6, Joel Peralta 1-1, Kyle Farnsworth 1-1|
|Batters Faced - David Price 24, Jake McGee 3, Joel Peralta 3, Kyle Farnsworth 2, Cesar Ramos 1, Brandon Gomes 5|
|Boston Red Sox|
|Jacoby Ellsbury, CF||5||1||1||0||0||1||0||.255|
|Shane Victorino, RF||5||0||2||1||0||2||0||.341|
|Dustin Pedroia, 2B||3||0||0||0||1||2||1||.289|
|Mike Napoli, 1B||4||0||1||0||0||1||1||.214|
|Will Middlebrooks, 3B||4||0||1||0||0||1||0||.225|
|Daniel Nava, LF||4||0||1||0||0||1||2||.391|
|Jonny Gomes, DH||2||0||0||0||2||1||0||.176|
|Stephen Drew, SS||4||0||0||0||0||1||3||.100|
|David Ross, C||3||1||1||1||0||1||0||.167|
|a- Jarrod Saltalamacchia, PH||1||0||0||0||0||1||0||.240|
|a-struck out for Ross in the 10th|
|HR - David Ross (1, Price)|
|RBI - Shane Victorino (6), David Ross (1)|
|2-OUT RBI - David Ross (1)|
|SB - Jacoby Ellsbury (5, 3rd base off Gomes/Lobaton), Shane Victorino (3, 2nd base off Price/Molina)|
|Team LOB - 8|
|DP - Pedroia-Drew-Napoli|
|Boston Red Sox|
|Junichi Tazawa (W,2-0)||1||1||0||0||0||0||0||1.50|
|WP - Jon Lester (3)|
|Pitches-Strikes - Jon Lester 100-63, Andrew Bailey 12-7, Joel Hanrahan 12-4, Koji Uehara 9-7, Junichi Tazawa 11-8|
|Ground Balls-Fly Balls - Jon Lester 8-7, Junichi Tazawa 1-2|
|Batters Faced - Jon Lester 26, Andrew Bailey 3, Joel Hanrahan 2, Koji Uehara 3, Junichi Tazawa 4|
|Attendance - 33039|
|Game Time - 3:23|
|Temperature - 45|
|Umpires - Home - Doug Eddings, First Base - John Tumpane, Second Base - Dana DeMuth, Third Base - Angel Hernandez|