The second-seeded Heat won the best-of-7 series 4-2 and will meet the third-seeded New Jersey Nets in the Eastern Conference semifinals.
O'Neal had 30 points and 20 rebounds while staying out of foul trouble as Miami won its first playoff series against the Bulls and its first postseason game in Chicago. O'Neal was 13-of-24 from the field.
Wade scored 23 points, and although he spent more time on the perimeter than usual, he was 7-of-12 from the field, including 2-of-3 on 3-pointers.
Wade injured his hip late in the first half of Game 5 on Tuesday, when he landed awkwardly after having his layup blocked by Michael Sweetney. He was injected with a painkiller at halftime, returned midway through the third quarter and scored 15 of his game-high 28 points to lead the Heat to a 92-78 victory.
After shooting just under 35 percent in Game 5, the Bulls missed 11 of their first 12 shots Thursday and finished 31-of-75 (41 percent). They were 10-for-30 on 3-pointers.
The Heat finished 38-of-77 from the field, including 11-of-25 on 3s.
Trailing 64-48 early in the third quarter, the Bulls scored seven points in a row, capped by Nocioni's transition basket that brought the crowd to its feet. But after a timeout, O'Neal went 1-of-2 from the line and jammed in a miss by Wade to make it 67-55.
The Bulls pulled within 97-88 on Gordon's three-point play with 4:58 left, but Haslem converted a three-point play after a miss by Posey at the shot-clock buzzer, and then hit a jumper. A steal and layup by Posey made it a 16-point game. O'Neal punctuated things with a dunk that made it 106-88 with 3:06 left.
The Heat were 0-9 in postseason games in Chicago and had lost three previous playoff series against the Bulls. Nothing about this series was easy.
Haslem tossed his mouthpiece toward an official in Game 1 and served a one-game suspension. Posey knocked down Hinrich in Game 3 and was suspended for Game 4. O'Neal couldn't avoid foul trouble in the first five games and was fined $25,000 after criticizing the officiating in Game 3. And teammates Gary Payton and Wade exchanged words near the end of the first half of Game 4.
- Miami F Antoine Walker and Bulls coach Scott Skiles exchanged words after the first half and received technical fouls.
- Chicago Bears safety Chris Harris was escorted from his seat behind the Miami bench early in the fourth quarter after an exchange with Heat C Alonzo Mourning. Harris and cornerback Nathan Vasher had front-row seats, while White Sox manager Ozzie Guillen and coach Harold Baines were five rows back. The White Sox's Joe Crede, Mark Buehrle, A.J. Pierzynski and Jon Garland were also at the game, as was Chicago Sky coach and former NBA great Dave Cowens.
- Sweetney picked up two fouls in the first 2:19 and sat the rest of the first half. He then picked up two more in the opening minute of the third quarter.