The Spurs (7-2) have won six of their last seven, while the Bulls (3-6) have dropped four of five.
Ben Gordon, coming off the bench for the third straight game after starting the first six, led the Bulls with 21 points in 25 minutes.
But Gordon came out of the game with 3:13 to go after slipping and injuring his left wrist or hand when he tried to break his fall while driving to the basket against the Spurs' Bruce Bowen.
The Spurs had their largest lead of 19 points with 6:41 left to play.
The Bulls erased a six-point Spurs lead with less than a minute remaining in the first quarter with three straight baskets by Gordon, including a 3-pointer, in 41 seconds. His 11-footer less than a minute into the second quarter gave Chicago a 29-28 lead.
But the Bulls started turning the ball over, committing 12 turnovers in the second quarter.
After edging into the lead by one point, Chicago gave the ball up four times during the next three minutes and fell behind 39-31.
The Bulls had a chance to cut the lead to three points with less than three minutes before halftime. But they committed four turnovers before the break and fell behind again by eight points.
The game began with a flurry of missed shots from Argentine players -- the Bulls' Andres Nocioni started 0-for-3, the Spurs' Manu Ginobili was 0-for-2 and Fabricio Oberto 0-for-1 before any other player missed. ... Nocioni went 0-for-9 until hitting a jumper with 5:47 left in the game. ... Parker, who was assessed a technical foul Wednesday against Charlotte for arguing a call, got a brief scolding from coach Gregg Popovich when he began arguing a call in the first quarter with referee Bill Kennedy.