Duncan scored 13 of his 25 points in the third quarter and Ginobili had 18 of his 25 in the fourth as the Spurs rallied to beat the Portland Trail Blazers 107-98 Monday night, extending their perfect road start to 6-0.
Tony Parker scored 14 for the Spurs, who fought through a sluggish first half while playing for the second straight night.
"We are really playing better on the road than at home," Ginobili said. "We have a better mentality. We grind games out for 48 minutes."
That's exactly what happened Monday. Duncan took over in the third, scoring on a variety of post moves as the Spurs ran their offense through him.
The fourth quarter belonged to Ginobili, who was 6-for-6 from the field in the quarter with two steals, a block and an assist. He nearly turned back the Blazers alone with standout play on both ends of the floor.
After converting a three-point play, Ginobili stole the ball and fed Brent Barry for a layup that made it 98-92. Ginobili then scored on four of the next five possessions for the Spurs. He came into the game shooting 29 percent on 3-pointers, but made all three in the final quarter.
"I needed a game like this," Ginobili said. "I don't know if it's going to be a turnaround for the whole season, but it's good for my confidence."
Defensive specialist Bruce Bowen held Randolph to just two points in the fourth. With Randolph silenced, much of the Blazers offensive output came from Dixon, who had 12 points in the quarter.
Jarrett Jack had 12 points and five assists for Portland. Barry had 10 points for the Spurs, who also won their final five road games last season.
Duncan, coming off a 35-point performance against Sacramento on Sunday night, shot 10-of-16 from the field and had six rebounds and five assists.
"He is hard to defend," Portland rookie LaMarcus Aldridge said. "He leans on you and when the double-team comes he kicks it out and they get it right back to him. He never stops moving."
A two-time NBA MVP, Duncan struggled against the Blazers last season, even as the Spurs won all four games. He averaged just 15 points on 45.1 percent shooting, including a season-low six points on 3-of-7 shooting in one game.
The Spurs have won six straight over the Blazers, and 13 of 14. They have also won seven of their last eight visits to the Rose Garden.
Randolph had 13 points in the first quarter and the Blazers led 25-22. Beno Udrih hit a 14-footer to give the Spurs their first lead at 35-33, but Portland quickly grabbed back the lead and had a 56-48 advantage at halftime. Duncan converted a three-point play to get the Spurs within 63-60, but the Blazers went on a 7-0 run and led 70-60.
Duncan then took over, sparking a 14-2 run that gave the Spurs the lead again at 74-72.
"When we have a team down we have to stay on them," Jack said.
- The Blazers haven't won a series against San Antonio since 1999-00.
- The Spurs' Barry wore a large bandage on his head, the result of a collision with Sacramento's Ronnie Price on Sunday that left Barry needing several stitches.
- The Spurs' win gave them the lead over Portland in the series for the first time since the 1982-83 season.