| Passing | ||||
| CP/AT | YDS | TD | INT | |
| M. Bulger | 34/53 | 295 | 1 | 2 |
| D. Looker | 0/0 | 0 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| A. Pittman | 14 | 95 | 0 | 24 |
| K. Darby | 7 | 26 | 0 | 13 |
| M. Bulger | 2 | 5 | 0 | 5 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Avery | 9 | 93 | 0 | 29 |
| K. Darby | 8 | 83 | 0 | 30 |
| T. Holt | 5 | 60 | 0 | 22 |
| D. Stanley | 3 | 21 | 0 | 16 |
| K. Burton | 2 | 13 | 0 | 7 |
| A. Becht | 1 | 8 | 0 | 8 |
| D. Looker | 2 | 8 | 1 | 6 |
| J. Klopfenstein | 1 | 5 | 0 | 5 |
| A. Pittman | 3 | 4 | 0 | 8 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| M. Bulger | 1 | 1 | 0 | -3 |
| T. Holt | 1 | 0 | 1 | 0 |
| T. Minor | 1 | 0 | 1 | 0 |
| A. Carriker | 0 | 0 | 1 | 0 |
| J. Craft | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| J. Brown | 3/4 | 48 | 1/1 | 10 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| D. Jones | 4 | 41.8 | 3 | 56 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Minor | 6 | 22.7 | 0 | 34 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| D. Looker | 5 | 3.8 | 0 | 13 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| W. Witherspoon | 9-3 | 0.0 | 0 | 0 |
| J. Craft | 5-1 | 2.0 | 0 | 0 |
| P. Tinoisamoa | 5-2 | 0.0 | 0 | 1 |
| J. Wade | 4-1 | 0.0 | 0 | 0 |
| O. Atogwe | 3-0 | 0.0 | 0 | 1 |
| F. Brown | 3-1 | 0.0 | 0 | 0 |
| C. Chavous | 3-1 | 0.0 | 0 | 0 |
| V. Adeyanju | 2-0 | 0.0 | 0 | 0 |
| Q. Culberson | 2-2 | 0.0 | 0 | 0 |
| L. Glover | 2-1 | 0.0 | 0 | 0 |
| L. Little | 2-0 | 0.0 | 0 | 0 |
| G. Stills | 2-0 | 0.0 | 0 | 0 |
| J. Brown | 1-0 | 0.0 | 0 | 0 |
| C. Chamberlain | 1-0 | 0.0 | 0 | 0 |
| R. Incognito | 1-0 | 0.0 | 0 | 0 |
| T. Johnson | 1-0 | 0.0 | 0 | 0 |
| A. Pittman | 1-0 | 0.0 | 0 | 0 |
| J. Bell | 0-1 | 0.0 | 0 | 0 |
| A. Goldberg | 0-1 | 0.0 | 0 | 0 |
| C. Long | 0-1 | 0.0 | 0 | 0 |
| C. Ryan | 0-1 | 0.0 | 0 | 0 |
| D. Vobora | 0-2 | 0.0 | 0 | 0 |
|
|
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| 4th Quarter | |
| J.Brown kicks 70 yards from SL 30 to end zone, Touchback. | |
| San Francisco at 1:56 | |
| 1-10-SF 20 | (1:56) D.Foster left tackle to SF 23 for 3 yards (Q.Culberson; F.Brown). |
| 2-7-SF 23 | (1:49) D.Foster up the middle to SF 25 for 2 yards (D.Vobora; Chris Long). |
| 3-5-SF 25 | (1:42) D.Foster left guard to SF 26 for 1 yard (C.Chamberlain). |
| 4-4-SF 26 | (1:38) A.Lee punts 50 yards to SL 24, Center-B.Jennings. D.Looker to SL 25 for 1 yard (D.Zeigler). |
| St. Louis at 1:28 | |
| 1-10-STL 25 | (1:28) (Shotgun) M.Bulger pass short middle to K.Darby to SL 30 for 5 yards (D.Strickland). Caught at SL 26. |
| 2-5-STL 30 | (1:09) (No Huddle, Shotgun) M.Bulger pass short right to D.Stanley to SL 34 for 4 yards (D.Strickland). Caught at SL 33. |
| 3-1-STL 34 | (:48) (No Huddle, Shotgun) M.Bulger pass short right to D.Avery to SL 34 for no gain (N.Clements). |
| 4-1-STL 34 | (:23) (No Huddle, Shotgun) M.Bulger pass incomplete short left to D.Looker. |
| San Francisco at :17 | |
| 1-10-STL 34 | (:17) J.O'Sullivan kneels to SL 35 for -1 yards. |
| 1st Quarter | ||
| TD | Frank Gore, 5 Yd run (Joe Nedney kick is good), 6:37. Drive: 4 plays, 34 yards in 1:54. | |
| 2nd Quarter | ||
| FG | Josh Brown 24 Yd, 13:26. Drive: 15 plays, 75 yards in 8:11. | |
| TD | Vernon Davis, 2 Yd pass from Shaun Hill (Joe Nedney kick is good), 10:38. Drive: 5 plays, 69 yards in 2:48. | |
| TD | Frank Gore, 1 Yd run (Joe Nedney kick is good), 7:50. Drive: 4 plays, 16 yards in 2:01. | |
| TD | Shaun Hill, 1 Yd run (Joe Nedney kick is good), 3:32. Drive: 7 plays, 60 yards in 3:14. | |
| TD | Bryant Johnson, 2 Yd pass from Shaun Hill (Joe Nedney kick is good), 0:34. Drive: 7 plays, 56 yards in 1:15. | |
| 3rd Quarter | ||
| FG | Josh Brown 48 Yd, 3:51. Drive: 10 plays, 42 yards in 2:26. | |
| FG | Josh Brown 44 Yd, 0:00. Drive: 7 plays, 51 yards in 2:19. | |
| 4th Quarter | ||
| TD | Dane Looker, 2 Yd pass from Marc Bulger (Josh Brown kick is good), 1:56. Drive: 11 plays, 59 yards in 2:38. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| S. Hill | 15/20 | 213 | 2 | 0 |
| J. O'Sullivan | 0/1 | 0 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 18 | 106 | 2 | 37 |
| D. Foster | 10 | 17 | 0 | 11 |
| M. Robinson | 3 | 11 | 0 | 10 |
| S. Hill | 3 | 5 | 1 | 3 |
| J. O'Sullivan | 1 | -1 | 0 | -1 |
| I. Bruce | 1 | -3 | 0 | -3 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| B. Johnson | 4 | 56 | 1 | 42 |
| M. Robinson | 2 | 54 | 0 | 36 |
| D. Foster | 2 | 40 | 0 | 31 |
| J. Hill | 3 | 33 | 0 | 22 |
| I. Bruce | 1 | 20 | 0 | 20 |
| F. Gore | 2 | 8 | 0 | 8 |
| V. Davis | 1 | 2 | 1 | 2 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| D. Foster | 1 | 1 | 0 | 0 |
| F. Gore | 1 | 1 | 0 | 0 |
| P. Haralson | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| J. Nedney | 0/0 | 0 | 5/5 | 5 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 6 | 51.8 | 0 | 58 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| M. Robinson | 1 | 15.0 | 0 | 15 |
| A. Rossum | 3 | 23.3 | 0 | 30 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| A. Rossum | 2 | 20.0 | 0 | 29 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| M. Lewis | 8-3 | 1.0 | 0 | 0 |
| D. Strickland | 8-1 | 0.0 | 0 | 1 |
| P. Willis | 5-3 | 0.0 | 0 | 0 |
| N. Clements | 4-2 | 0.0 | 1 | 0 |
| M. Roman | 4-0 | 0.0 | 0 | 0 |
| P. Haralson | 3-0 | 1.0 | 0 | 0 |
| W. Harris | 3-0 | 1.0 | 1 | 0 |
| M. Lawson | 3-0 | 1.0 | 0 | 0 |
| T. Spikes | 3-3 | 0.0 | 0 | 0 |
| T. Banta-Cain | 2-1 | 0.0 | 0 | 0 |
| M. Hudson | 2-1 | 0.0 | 0 | 0 |
| D. Zeigler | 2-0 | 0.0 | 0 | 0 |
| B. Bajema | 1-1 | 0.0 | 0 | 0 |
| K. Balmer | 1-0 | 0.0 | 0 | 0 |
| T. Brown | 1-2 | 0.0 | 0 | 0 |
| D. Foster | 1-0 | 0.0 | 0 | 0 |
| A. Franklin | 1-0 | 0.0 | 0 | 0 |
| K. Lewis | 1-2 | 0.0 | 0 | 0 |
| J. Smith | 1-2 | 0.0 | 0 | 0 |
| R. Smith | 1-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 1-2 | 0.0 | 0 | 0 |
| J. Ulbrich | 1-2 | 0.0 | 0 | 0 |
| R. Green | 0-1 | 0.0 | 0 | 0 |
| R. McDonald | 0-1 | 0.0 | 0 | 0 |
| M. Robinson | 0-1 | 0.0 | 0 | 0 |
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