| Passing | ||||
| CP/AT | YDS | TD | INT | |
| A. Smith | 21/33 | 291 | 2 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 15 | 127 | 1 | 40 |
| K. Hunter | 9 | 38 | 0 | 14 |
| A. Smith | 1 | -1 | 0 | -1 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| M. Crabtree | 5 | 68 | 0 | 38 |
| J. Morgan | 3 | 65 | 1 | 30 |
| K. Hunter | 2 | 62 | 0 | 44 |
| V. Davis | 4 | 45 | 1 | 26 |
| D. Walker | 3 | 20 | 0 | 11 |
| B. Miller | 1 | 15 | 0 | 15 |
| F. Gore | 2 | 12 | 0 | 10 |
| K. Williams | 1 | 4 | 0 | 4 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| A. Smith | 2 | 1 | 1 | 0 |
| N. Bowman | 0 | 0 | 1 | 0 |
| D. Goldson | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 1/3 | 37 | 3/3 | 6 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 4 | 49.5 | 0 | 68 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 3 | 24.7 | 0 | 30 |
| K. Hunter | 1 | 16.0 | 0 | 16 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 2 | -3.0 | 0 | 0 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| D. Goldson | 10-0 | 0.0 | 0 | 0 |
| N. Bowman | 6-0 | 0.0 | 0 | 0 |
| P. Willis | 6-0 | 0.0 | 0 | 0 |
| C. Culliver | 4-0 | 0.0 | 0 | 0 |
| T. Brown | 4-0 | 0.0 | 0 | 0 |
| A. Smith | 4-1 | 1.5 | 0 | 0 |
| R. Smith | 3-0 | 0.0 | 0 | 0 |
| A. Brooks | 3-0 | 0.0 | 0 | 0 |
| J. Smith | 3-0 | 0.0 | 0 | 1 |
| S. Spencer | 2-0 | 0.0 | 0 | 0 |
| M. Iupati | 1-0 | 0.0 | 0 | 0 |
| B. Miller | 1-0 | 0.0 | 0 | 0 |
| A. Dixon | 1-0 | 0.0 | 0 | 0 |
| C. Rogers | 1-0 | 0.0 | 1 | 0 |
| M. Williams | 1-0 | 0.0 | 0 | 0 |
| T. Gooden | 1-0 | 0.0 | 0 | 0 |
| R. McDonald | 0-1 | 0.5 | 0 | 0 |
|
|
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| 4th Quarter | |
| Philadelphia at 2:29 | |
| 2-2-PHI 41 | (2:29) M.Vick pass short left to J.Avant ran ob at PHI 46 for 5 yards. |
| 1-10-PHI 46 | (2:24) (Shotgun) M.Vick pass incomplete short right to D.Jackson (A.Brooks). |
| 2-10-PHI 46 | (2:21) (Shotgun) M.Vick scrambles right guard to PHI 46 for no gain (Ald.Smith). PENALTY on SF-A.Brooks, Defensive Offside, 5 yards, enforced at PHI 46 - No Play. |
| 2-5-SF 49 | (2:15) (Shotgun) M.Vick pass short left to J.Maclin to SF 32 for 17 yards (J.Smith). FUMBLES (J.Smith), RECOVERED by SF-D.Goldson at SF 31. D.Goldson to SF 31 for no gain (K.DeVan). PHI-J.Peters was injured during the play. His return is Questionable. |
| San Francisco at 2:06 | |
| 1-10-SF 31 | (2:06) F.Gore up the middle to SF 35 for 4 yards (N.Allen). |
| 2-6-SF 35 | (2:02) F.Gore right end to SF 43 for 8 yards (J.Chaney). |
| 1-10-SF 43 | (1:56) F.Gore up the middle to SF 47 for 4 yards (T.Laws). |
| 2-6-SF 47 | (1:50) F.Gore up the middle to PHI 48 for 5 yards (B.Rolle). |
| 3-1-PHI 48 | (1:04) F.Gore up the middle to PHI 43 for 5 yards (N.Asomugha). |
| 1-10-PHI 43 | (:24) Alex Smith kneels to PHI 44 for -1 yards. |
| 1st Quarter | ||
| TD | Clay Harbor, 16 Yd pass from Michael Vick (Alex Henery kick is good), 4:08. Drive: 6 plays, 76 yards in 3:28. | |
| 2nd Quarter | ||
| FG | David Akers, 37 Yd, 14:22. Drive: 9 plays, 57 yards in 4:46. | |
| FG | Alex Henery, 32 Yd, 12:08. Drive: 6 plays, 66 yards in 2:14. | |
| FG | Alex Henery, 32 Yd, 1:52. Drive: 10 plays, 56 yards in 4:08. | |
| TD | LeSean McCoy, 5 Yd pass from Michael Vick (Alex Henery kick is good), 0:38. Drive: 5 plays, 23 yards in 0:54. | |
| 3rd Quarter | ||
| FG | Alex Henery, 33 Yd, 9:30. Drive: 5 plays, 25 yards in 2:14. | |
| TD | Josh Morgan, 30 Yd pass from Alex Smith (David Akers kick is good), 7:20. Drive: 4 plays, 80 yards in 2:10. | |
| TD | Vernon Davis, 9 Yd pass from Alex Smith (David Akers kick is good), 2:58. Drive: 5 plays, 77 yards in 2:32. | |
| 4th Quarter | ||
| TD | Frank Gore, 12 Yd run (David Akers kick is good), 3:00. Drive: 8 plays, 77 yards in 3:28. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| M. Vick | 30/46 | 416 | 2 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| M. Vick | 8 | 75 | 0 | 24 |
| L. McCoy | 9 | 18 | 0 | 5 |
| R. Brown | 3 | 15 | 0 | 15 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Jackson | 6 | 171 | 0 | 61 |
| J. Maclin | 7 | 74 | 0 | 19 |
| J. Avant | 6 | 69 | 0 | 20 |
| C. Harbor | 3 | 55 | 1 | 27 |
| L. McCoy | 6 | 34 | 1 | 15 |
| O. Schmitt | 1 | 11 | 0 | 11 |
| B. Celek | 1 | 2 | 0 | 2 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| R. Brown | 1 | 1 | 0 | 0 |
| J. Maclin | 1 | 1 | 0 | 0 |
| C. Jenkins | 0 | 0 | 1 | 3 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| A. Henery | 3/5 | 33 | 2/2 | 11 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| C. Henry | 2 | 43.5 | 0 | 45 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| D. Lewis | 2 | 20.0 | 0 | 21 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| D. Jackson | 1 | -1.0 | 0 | -1 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| J. Chaney | 6-2 | 0.0 | 0 | 0 |
| J. Page | 6-1 | 0.0 | 0 | 0 |
| B. Rolle | 5-0 | 0.0 | 0 | 0 |
| A. Samuel | 4-0 | 0.0 | 0 | 0 |
| T. Laws | 3-0 | 0.0 | 0 | 0 |
| J. Babin | 3-0 | 3.0 | 0 | 1 |
| N. Asomugha | 3-1 | 0.0 | 0 | 0 |
| D. Rodgers-Cromartie | 3-0 | 0.0 | 0 | 0 |
| N. Allen | 3-0 | 0.0 | 0 | 0 |
| K. DeVan | 2-0 | 0.0 | 0 | 0 |
| C. Anderson | 2-0 | 0.0 | 0 | 0 |
| M. Fokou | 2-1 | 0.0 | 0 | 0 |
| P. Hunt | 1-0 | 0.0 | 0 | 0 |
| J. Avant | 1-0 | 0.0 | 0 | 0 |
| A. Dixon | 1-0 | 0.0 | 0 | 0 |
| C. Jenkins | 1-0 | 0.0 | 0 | 0 |
| J. Maclin | 1-0 | 0.0 | 0 | 0 |
| M. Patterson | 1-0 | 0.0 | 0 | 0 |
| A. Jordan | 1-0 | 0.0 | 0 | 0 |
| K. Clayton | 1-0 | 0.0 | 0 | 0 |
| J. Hanson | 1-1 | 0.0 | 0 | 0 |
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