| Passing | ||||
| CP/AT | YDS | TD | INT | |
| C. McCoy | 22/34 | 241 | 1 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| C. Ogbonnaya | 11 | 37 | 0 | 7 |
| C. McCoy | 8 | 30 | 0 | 9 |
| M. Hardesty | 2 | 6 | 0 | 5 |
| O. Marecic | 1 | 1 | 0 | 1 |
| G. Little | 1 | -8 | 0 | -8 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| B. Watson | 3 | 64 | 0 | 29 |
| J. Cribbs | 2 | 56 | 1 | 45 |
| J. Norwood | 5 | 32 | 0 | 14 |
| G. Little | 4 | 28 | 0 | 9 |
| C. Ogbonnaya | 5 | 24 | 0 | 8 |
| A. Smith | 1 | 20 | 0 | 20 |
| E. Moore | 2 | 17 | 0 | 12 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| C. McCoy | 4 | 1 | 3 | -1 |
| C. Ogbonnaya | 1 | 0 | 0 | 0 |
| J. Thomas | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| P. Dawson | 1/1 | 52 | 1/1 | 4 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| B. Maynard | 6 | 44.0 | 4 | 55 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| J. Cribbs | 4 | 25.5 | 0 | 31 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| J. Cribbs | 3 | 11.3 | 0 | 17 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| D. Jackson | 10-0 | 0.0 | 0 | 0 |
| A. Rubin | 8-0 | 0.0 | 0 | 0 |
| M. Adams | 6-1 | 0.0 | 0 | 0 |
| J. Haden | 5-1 | 0.0 | 0 | 0 |
| U. Young | 4-0 | 0.0 | 0 | 0 |
| C. Gocong | 4-1 | 0.0 | 0 | 0 |
| J. Mitchell | 3-0 | 0.0 | 0 | 0 |
| S. Brown | 3-0 | 0.0 | 0 | 0 |
| J. Sheard | 2-1 | 0.0 | 0 | 0 |
| S. Fujita | 2-0 | 0.0 | 0 | 0 |
| K. Maiava | 2-0 | 0.0 | 0 | 0 |
| P. Taylor | 2-0 | 1.0 | 0 | 1 |
| A. Mack | 1-0 | 0.0 | 0 | 0 |
| B. Skrine | 1-1 | 0.0 | 0 | 0 |
| B. Schaefering | 1-0 | 0.0 | 0 | 0 |
| D. Patterson | 1-0 | 0.0 | 0 | 0 |
| R. Pontbriand | 1-0 | 0.0 | 0 | 0 |
| T. Ward | 0-1 | 0.0 | 0 | 0 |
| J. Cribbs | 0-1 | 0.0 | 0 | 0 |
|
|
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| 4th Quarter | |
| San Francisco at 2:14 | |
| 3-5-CLE 9 | (2:14) Alex Smith scrambles left tackle to CLV 8 for 1 yard. |
| 4-4-CLE 8 | (2:00) D.Akers 26 yard field goal is GOOD, Center-B.Jennings, Holder-A.Lee. |
| D.Akers kicks 71 yards from SF 35 to CLV -6. J.Cribbs to CLV 25 for 31 yards (T.Gooden). | |
| Cleveland at 1:51 | |
| 1-10-CLE 25 | (1:51) (Shotgun) C.McCoy pass short right to C.Ogbonnaya pushed ob at CLV 32 for 7 yards (C.Culliver). Caught at CLV 32. 1-yd YAC. |
| 2-3-CLE 32 | (1:46) (Shotgun) C.McCoy pass short middle to J.Norwood to CLV 35 for 3 yards (D.Whitner) [J.Smith]. PENALTY on SF-J.Smith, Roughing the Passer, 15 yards, enforced at CLV 35. |
| 1-10-50 | (1:35) (Shotgun) C.McCoy pass short middle to B.Watson to SF 31 for 19 yards (T.Brown). Caught at SF 39. 8-yds YAC. |
| 1-10-SF 31 | (1:10) (Shotgun) C.McCoy pass incomplete deep left to J.Cribbs. |
| 2-10-SF 31 | (1:10) (Shotgun) C.McCoy sacked at SF 34 for -3 yards (P.Willis). |
| 3-13-SF 34 | (:44) (No Huddle, Shotgun) C.McCoy to SF 41 for -7 yards (P.Haralson). FUMBLES (P.Haralson), and recovers at SF 45. C.McCoy pass short left to C.Ogbonnaya to SF 26 for 8 yards (T.Brown). Caught at SF 36. 10-yds YAC. |
| 4-5-SF 26 | (:14) C.McCoy pass short middle to G.Little to SF 18 for 8 yards (N.Bowman). |
| 1st Quarter | ||
| TD | Frank Gore, 4 Yd run (David Akers kick is good), 12:44. Drive: 4 plays, 20 yards in 1:35. | |
| FG | David Akers, 29 Yd, 2:55. Drive: 11 plays, 88 yards in 7:03. | |
| 2nd Quarter | ||
| TD | Michael Crabtree, 2 Yd pass from Alex Smith (David Akers kick is good), 1:31. Drive: 12 plays, 64 yards in 4:21. | |
| FG | Phil Dawson, 52 Yd, 0:00. Drive: 8 plays, 50 yards in 1:31. | |
| 3rd Quarter | ||
| None | ||
| 4th Quarter | ||
| TD | Josh Cribbs, 45 Yd pass from Colt McCoy (Phil Dawson kick is good), 6:17. Drive: 8 plays, 80 yards in 2:24. | |
| FG | David Akers, 26 Yd, 1:56. Drive: 11 plays, 67 yards in 4:21. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| A. Smith | 15/24 | 177 | 1 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 31 | 134 | 1 | 26 |
| K. Hunter | 3 | 26 | 0 | 26 |
| A. Smith | 4 | 22 | 0 | 9 |
| T. Ginn | 1 | -8 | 0 | -8 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| M. Crabtree | 5 | 54 | 1 | 41 |
| B. Edwards | 4 | 42 | 0 | 13 |
| V. Davis | 3 | 27 | 0 | 19 |
| J. Peelle | 1 | 19 | 0 | 19 |
| I. Sopoaga | 1 | 18 | 0 | 18 |
| J. Staley | 1 | 17 | 0 | 17 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| A. Smith | 1 | 0 | 1 | 0 |
| I. Sopoaga | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 2/2 | 29 | 2/2 | 8 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 5 | 53.6 | 2 | 65 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 2 | 16.5 | 0 | 22 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 2 | 9.0 | 0 | 18 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Bowman | 11-1 | 0.0 | 0 | 0 |
| P. Willis | 6-1 | 1.0 | 0 | 0 |
| C. Culliver | 5-0 | 0.0 | 0 | 0 |
| J. Smith | 4-0 | 0.0 | 0 | 0 |
| C. Rogers | 3-0 | 0.0 | 0 | 0 |
| A. Brooks | 3-0 | 2.0 | 0 | 1 |
| D. Whitner | 3-0 | 0.0 | 0 | 1 |
| D. Goldson | 3-1 | 0.0 | 1 | 0 |
| P. Haralson | 2-0 | 0.0 | 0 | 1 |
| T. Brown | 2-1 | 0.0 | 0 | 0 |
| T. Gooden | 2-0 | 0.0 | 0 | 0 |
| A. Smith | 2-0 | 1.0 | 0 | 0 |
| R. Jean Francois | 1-0 | 0.0 | 0 | 0 |
| A. Dixon | 1-0 | 0.0 | 0 | 0 |
| R. McDonald | 1-0 | 0.0 | 0 | 0 |
| C. Spillman | 1-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 1-0 | 0.0 | 0 | 0 |
| B. Costanzo | 1-0 | 0.0 | 0 | 0 |
| M. Williams | 1-0 | 0.0 | 0 | 0 |
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