| Passing | ||||
| CP/AT | YDS | TD | INT | |
| R. Fitzpatrick | 13/34 | 176 | 0 | 2 |
| T. Thigpen | 2/3 | 19 | 0 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| C. Spiller | 12 | 46 | 0 | 16 |
| R. Fitzpatrick | 5 | 26 | 0 | 18 |
| T. Choice | 1 | 12 | 0 | 12 |
| T. Thigpen | 1 | 8 | 0 | 8 |
| J. White | 1 | 4 | 0 | 4 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| S. Johnson | 4 | 116 | 0 | 53 |
| D. Hagan | 2 | 28 | 0 | 17 |
| D. Nelson | 2 | 20 | 0 | 10 |
| M. Caussin | 2 | 19 | 0 | 13 |
| C. Spiller | 3 | 10 | 0 | 6 |
| T. Choice | 1 | 2 | 0 | 2 |
| L. Smith | 1 | 0 | 0 | 0 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| B. Scott | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Rayner | 1/2 | 37 | 1/1 | 4 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| B. Moorman | 2 | 35.5 | 0 | 55 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| J. Rogers | 4 | 24.0 | 0 | 33 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| Defense | ||||
| T-A | SCK | INT | FF | |
| K. Sheppard | 11-3 | 0.0 | 0 | 0 |
| B. Scott | 8-0 | 0.0 | 0 | 0 |
| N. Barnett | 6-2 | 0.0 | 0 | 0 |
| G. Wilson | 5-1 | 0.0 | 0 | 0 |
| D. Edwards | 4-2 | 0.0 | 0 | 0 |
| M. Dareus | 3-2 | 1.0 | 0 | 0 |
| C. Kelsay | 3-3 | 0.0 | 0 | 0 |
| L. McKelvin | 3-1 | 0.0 | 0 | 0 |
| S. Johnson | 3-0 | 0.0 | 0 | 0 |
| A. Moats | 2-0 | 0.0 | 0 | 0 |
| A. Levitre | 1-0 | 0.0 | 0 | 0 |
| K. Heard | 1-1 | 0.0 | 0 | 0 |
| J. Byrd | 1-2 | 0.0 | 0 | 0 |
| C. Rinehart | 1-0 | 0.0 | 0 | 0 |
| D. Searcy | 1-0 | 0.0 | 0 | 0 |
| A. Carrington | 1-0 | 0.0 | 0 | 0 |
| D. Florence | 1-1 | 0.0 | 0 | 0 |
| J. Rogers | 1-0 | 0.0 | 0 | 0 |
|
|
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| 4th Quarter | |
| San Diego at 3:50 | |
| 2-7-SD 16 | (3:50) J.Hester up the middle to SD 19 for 3 yards (N.Barnett, M.Dareus). |
| 3-4-SD 19 | (3:13) J.Hester up the middle to SD 20 for 1 yard (C.Kelsay). |
| 4-3-SD 20 | (2:32) M.Scifres punts 58 yards to BUF 22, Center-M.Windt, fair catch by L.McKelvin. |
| Buffalo at 2:24 | |
| 1-10-BUF 22 | (2:24) (Shotgun) J.White right end to BUF 26 for 4 yards (B.Bird, Q.Jammer). |
| 2-6-BUF 26 | (2:00) (Shotgun) T.Thigpen pass short left to M.Caussin to BUF 39 for 13 yards (S.Gregory). |
| 1-10-BUF 39 | (1:34) (Shotgun) T.Thigpen scrambles right end ran ob at BUF 47 for 8 yards (A.Gachkar). |
| 2-2-BUF 47 | (1:26) (Shotgun) T.Thigpen pass short middle to M.Caussin to SD 47 for 6 yards (S.Gregory). |
| 1-10-SD 47 | (:59) (Shotgun) T.Thigpen pass deep left intended for D.Hagan INTERCEPTED by M.Gilchrist at SD 30. M.Gilchrist to BUF 49 for 21 yards (A.Levitre). |
| San Diego at :50 | |
| 1-10-BUF 49 | (:50) B.Volek kneels, dead ball declared at 50 for -1 yards. |
| 2-11-50 | (:28) B.Volek kneels, dead ball declared at SD 49 for -1 yards. |
| 1st Quarter | ||
| TD | Antonio Gates, 9 Yd pass from Philip Rivers (Nick Novak kick is good), 7:52. Drive: 12 plays, 80 yards in 7:08. | |
| 2nd Quarter | ||
| TD | Mike Tolbert, 1 Yd run (Nick Novak kick Failed), 14:16. Drive: 10 plays, 55 yards in 5:33. | |
| FG | Nick Novak, 47 Yd, 6:41. Drive: 6 plays, 46 yards in 2:29. | |
| 3rd Quarter | ||
| FG | Dave Rayner, 37 Yd, 11:43. Drive: 8 plays, 60 yards in 3:17. | |
| TD | Bryan Scott, 0 Yd fumble return (Dave Rayner kick is good), 10:11. | |
| TD | Antonio Gates, 2 Yd pass from Philip Rivers (Nick Novak kick is good), 4:11. Drive: 11 plays, 78 yards in 6:00. | |
| TD | Steve Gregory, 26 Yd interception return (Nick Novak kick is good), 4:02. | |
| 4th Quarter | ||
| TD | Patrick Crayton, 26 Yd pass from Philip Rivers (Nick Novak kick is good), 9:01. Drive: 11 plays, 77 yards in 7:05. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| P. Rivers | 24/33 | 240 | 3 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| R. Mathews | 20 | 114 | 0 | 37 |
| M. Tolbert | 6 | 21 | 1 | 13 |
| E. Weddle | 1 | 10 | 0 | 10 |
| J. Hester | 3 | 7 | 0 | 3 |
| B. Volek | 2 | -2 | 0 | -1 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| A. Gates | 7 | 68 | 2 | 17 |
| V. Jackson | 5 | 55 | 0 | 17 |
| P. Crayton | 3 | 37 | 1 | 26 |
| R. Mathews | 6 | 34 | 0 | 10 |
| M. Floyd | 2 | 29 | 0 | 15 |
| R. McMichael | 1 | 17 | 0 | 17 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| P. Rivers | 1 | 1 | 0 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| N. Novak | 1/1 | 47 | 4/5 | 7 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| M. Scifres | 3 | 39.7 | 2 | 58 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| R. Goodman | 2 | 21.0 | 0 | 23 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| P. Crayton | 1 | 14.0 | 0 | 14 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| S. Gregory | 7-0 | 0.0 | 1 | 0 |
| D. Hughes | 4-0 | 0.0 | 0 | 0 |
| Q. Jammer | 4-2 | 0.0 | 0 | 0 |
| T. Spikes | 3-3 | 0.0 | 0 | 0 |
| A. Cason | 3-0 | 0.0 | 0 | 0 |
| C. Liuget | 2-0 | 0.0 | 0 | 0 |
| S. Phillips | 2-1 | 0.0 | 0 | 0 |
| M. Tolbert | 2-1 | 0.0 | 0 | 0 |
| A. Barnes | 2-1 | 1.0 | 0 | 0 |
| E. Weddle | 2-1 | 0.0 | 1 | 0 |
| B. Bird | 1-0 | 0.0 | 0 | 0 |
| T. LaBoy | 1-1 | 0.0 | 0 | 0 |
| N. Diggs | 1-1 | 0.0 | 0 | 0 |
| V. Martin | 1-1 | 0.0 | 0 | 0 |
| S. Wright | 1-0 | 0.0 | 0 | 0 |
| A. Gachkar | 1-0 | 0.0 | 0 | 0 |
| C. Thomas | 1-0 | 0.0 | 0 | 0 |
| A. Garay | 1-1 | 0.0 | 0 | 0 |
| M. Gilchrist | 0-0 | 0.0 | 1 | 0 |
| D. Butler | 0-2 | 0.0 | 0 | 0 |
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