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| Passing | ||||
| CP/AT | YDS | TD | INT | |
| M. Cassel | 23/42 | 301 | 2 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| P. Hillis | 11 | 66 | 0 | 18 |
| S. Draughn | 5 | 56 | 0 | 25 |
| M. Cassel | 2 | 25 | 0 | 21 |
| J. Charles | 6 | 3 | 0 | 8 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Bowe | 8 | 102 | 2 | 33 |
| J. Baldwin | 3 | 62 | 0 | 26 |
| D. McCluster | 4 | 32 | 0 | 12 |
| K. Boss | 1 | 29 | 0 | 29 |
| P. Hillis | 2 | 25 | 0 | 15 |
| S. Draughn | 1 | 23 | 0 | 23 |
| J. Charles | 3 | 19 | 0 | 10 |
| T. Moeaki | 1 | 9 | 0 | 9 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| P. Hillis | 1 | 1 | 0 | 0 |
| S. Breaston | 1 | 0 | 1 | 0 |
| M. Cassel | 1 | 1 | 0 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| R. Succop | 1/1 | 33 | 2/2 | 5 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| D. Colquitt | 7 | 44.7 | 2 | 66 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| J. Arenas | 2 | 20.0 | 0 | 23 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| J. Arenas | 3 | 13.3 | 0 | 23 |
| S. Breaston | 1 | 21.0 | 0 | 21 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| D. Johnson | 7-2 | 0.0 | 0 | 0 |
| A. Elam | 6-3 | 0.0 | 0 | 0 |
| J. Houston | 4-1 | 0.0 | 0 | 0 |
| T. Hali | 3-1 | 0.0 | 0 | 0 |
| E. Berry | 3-1 | 0.0 | 0 | 0 |
| T. Jackson | 2-2 | 0.0 | 0 | 0 |
| J. Arenas | 2-1 | 0.0 | 0 | 0 |
| S. Routt | 2-0 | 0.0 | 0 | 0 |
| D. Poe | 2-1 | 0.0 | 0 | 0 |
| E. Jones | 2-0 | 0.0 | 0 | 0 |
| B. Siler | 1-0 | 0.0 | 0 | 0 |
| G. Dorsey | 1-2 | 0.0 | 0 | 0 |
| B. Flowers | 1-0 | 0.0 | 0 | 0 |
| E. Winston | 1-0 | 0.0 | 0 | 0 |
| T. Hartman | 1-0 | 0.0 | 0 | 0 |
| R. Pitoitua | 1-2 | 0.0 | 0 | 0 |
| J. Powe | 1-0 | 0.0 | 0 | 0 |
| T. Daniels | 0-1 | 0.0 | 0 | 0 |
| J. Belcher | 0-1 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| Kansas City | 0 | 0 | 3 | 14 |
| Buffalo | 7 | 14 | 14 | 0 |
| 1st Quarter | ||
 | TD @ 2:01 | C.J. Spiller runs for 17 yards (Rian Lindell kick is good). Drive: 11 plays, 84 yards in 5:52. |
| 2nd Quarter | ||
| TD @ 12:29 | C.J. Spiller runs for 5 yards (Rian Lindell kick is good). Drive: 7 plays, 67 yards in 2:55. |
| TD @ 3:29 | Scott Chandler catches a 10 yard pass from Ryan Fitzpatrick (Rian Lindell kick is good). Drive: 6 plays, 43 yards in 3:29. |
| 3rd Quarter | ||
 | FG @ 7:32 | Ryan Succop makes a 33 yard kick. Drive: 7 plays, 23 yards in 3:33. |
| TD @ 5:35 | Steve Johnson catches a 49 yard pass from Ryan Fitzpatrick (Rian Lindell kick is good). Drive: 4 plays, 80 yards in 1:57. |
| TD @ 3:46 | Leodis McKelvin runs 88 yards for a punt return (Rian Lindell kick is good). |
| 4th Quarter | ||
| TD @ 6:26 | Dwayne Bowe catches a 33 yard pass from Matt Cassel (Ryan Succop kick is good). Drive: 5 plays, 80 yards in 2:13. |
| TD @ 1:10 | Dwayne Bowe catches a 2 yard pass from Matt Cassel (Ryan Succop kick is good). Drive: 9 plays, 83 yards in 2:51. |
| 4th Quarter | |
| R.Succop kicks 65 yards from KC 35 to end zone, Touchback. Kick through end zone. | |
| Buffalo at 1:10 | |
| 1-10-BUF 20 | (1:10) T.Thigpen kneels to BUF 19 for -1 yards. |
| 2-11-BUF 19 | (1:07) J.White left guard to BUF 21 for 2 yards (J.Powe). |
| 3-9-BUF 21 | (1:00) J.White up the middle to BUF 21 for no gain (E.Jones). |
| 4-9-BUF 21 | (:50) B.Moorman punts 48 yards to KC 31, Center-G.Sanborn. S.Breaston MUFFS catch, and recovers at KC 31. S.Breaston to BUF 48 for 21 yards (N.Bradham). |
| Kansas City at :35 | |
| 1-10-BUF 48 | (:35) (Shotgun) M.Cassel pass incomplete deep middle to T.Moeaki. Thrown behind receiver at BUF 30. |
| 2-10-BUF 48 | (:30) (No Huddle, Shotgun) S.Draughn right guard to BUF 30 for 18 yards (T.McGee). |
| 1-10-BUF 30 | (:14) (No Huddle) M.Cassel spiked the ball to stop the clock. |
| 2-10-BUF 30 | (:12) (Shotgun) M.Cassel pass incomplete deep right to D.Bowe (G.Wilson). Receiver and coverage along sideline at goal line. |
| 3-10-BUF 30 | (:05) (Shotgun) M.Cassel pass deep middle intended for S.Breaston INTERCEPTED by J.Byrd at BUF -9. Touchback. |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| R. Fitzpatrick | 10/19 | 178 | 2 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| C. Spiller | 15 | 123 | 2 | 38 |
| T. Choice | 8 | 37 | 0 | 9 |
| R. Fitzpatrick | 4 | 34 | 0 | 20 |
| J. White | 5 | 11 | 0 | 5 |
| B. Smith | 2 | 5 | 0 | 5 |
| T. Thigpen | 1 | -1 | 0 | -1 |
| D. Dickerson | 1 | -8 | 0 | -8 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| S. Johnson | 2 | 56 | 1 | 49 |
| S. Chandler | 2 | 53 | 1 | 43 |
| C. Spiller | 3 | 47 | 0 | 27 |
| B. Smith | 1 | 16 | 0 | 16 |
| T. Graham | 1 | 7 | 0 | 7 |
| D. Jones | 1 | -1 | 0 | -1 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| B. Smith | 1 | 0 | 1 | -15 |
| M. Williams | 0 | 0 | 1 | 0 |
| B. Scott | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| R. Lindell | 0/0 | 0 | 5/5 | 5 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| B. Moorman | 7 | 49.9 | 1 | 60 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. McKelvin | 2 | 0.0 | 0 | 0 |
| B. Smith | 1 | 5.0 | 0 | 5 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| L. McKelvin | 3 | 32.7 | 1 | 88 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| S. Gilmore | 7-0 | 0.0 | 0 | 0 |
| K. Sheppard | 4-0 | 1.0 | 0 | 0 |
| J. Byrd | 4-3 | 0.0 | 1 | 0 |
| N. Barnett | 3-3 | 0.0 | 0 | 1 |
| A. Williams | 3-0 | 0.0 | 0 | 0 |
| T. McGee | 3-2 | 0.0 | 0 | 0 |
| G. Wilson | 3-2 | 0.0 | 0 | 0 |
| D. Searcy | 3-1 | 0.0 | 0 | 0 |
| C. White | 3-0 | 0.0 | 0 | 0 |
| M. Anderson | 3-0 | 0.0 | 0 | 0 |
| A. Moats | 2-1 | 0.0 | 0 | 0 |
| M. Williams | 2-0 | 0.0 | 0 | 0 |
| M. Dareus | 2-0 | 1.0 | 0 | 0 |
| K. Williams | 2-1 | 2.0 | 0 | 0 |
| N. Bradham | 2-1 | 0.0 | 0 | 0 |
| R. Martin | 1-0 | 0.0 | 0 | 0 |
| A. Carrington | 1-0 | 1.0 | 0 | 1 |
| S. Johnson | 1-0 | 0.0 | 0 | 0 |
| J. Rogers | 0-1 | 0.0 | 0 | 0 |
| B. Scott | 0-1 | 0.0 | 0 | 0 |
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