| Passing | ||||
| CP/AT | YDS | TD | INT | |
| P. Rivers | 24/40 | 258 | 2 | 2 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| R. Mathews | 15 | 47 | 0 | 11 |
| R. Brown | 4 | 9 | 0 | 5 |
| J. Battle | 4 | -3 | 0 | 1 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Alexander | 7 | 96 | 2 | 21 |
| M. Floyd | 4 | 67 | 0 | 38 |
| R. Mathews | 4 | 36 | 0 | 24 |
| L. Green | 3 | 25 | 0 | 12 |
| A. Gates | 2 | 17 | 0 | 13 |
| R. Meachem | 1 | 10 | 0 | 10 |
| R. Brown | 2 | 6 | 0 | 5 |
| J. Battle | 1 | 1 | 0 | 1 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| P. Rivers | 3 | 1 | 1 | 0 |
| A. Barnes | 0 | 0 | 1 | 1 |
| R. Hadnot | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| N. Novak | 0/0 | 0 | 3/3 | 3 |
| M. Scifres | 0/0 | 0 | 1/1 | 1 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| M. Scifres | 9 | 54.8 | 3 | 66 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| A. Cason | 1 | 16.0 | 0 | 16 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| A. Cason | 1 | 9.0 | 0 | 9 |
| E. Royal | 1 | 1.0 | 0 | 1 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| D. Butler | 7-1 | 0.0 | 0 | 1 |
| S. Wright | 6-0 | 0.0 | 0 | 0 |
| M. Gilchrist | 5-1 | 0.0 | 0 | 0 |
| E. Weddle | 5-1 | 0.0 | 1 | 0 |
| S. Phillips | 4-1 | 1.0 | 0 | 0 |
| K. Reyes | 3-0 | 2.0 | 0 | 0 |
| Q. Jammer | 3-0 | 0.0 | 0 | 0 |
| C. Thomas | 2-0 | 0.0 | 0 | 0 |
| D. Williams | 2-1 | 0.0 | 0 | 0 |
| M. Ingram | 2-1 | 0.0 | 0 | 0 |
| M. Floyd | 2-0 | 0.0 | 0 | 0 |
| A. Cason | 2-0 | 0.0 | 0 | 0 |
| A. Bigby | 2-2 | 0.0 | 0 | 0 |
| J. Johnson | 1-0 | 0.0 | 0 | 0 |
| A. Gachkar | 1-0 | 0.0 | 0 | 0 |
| D. Stuckey | 1-0 | 0.0 | 0 | 1 |
| J. Battle | 1-0 | 0.0 | 0 | 0 |
| V. Martin | 1-0 | 0.0 | 0 | 0 |
| T. Spikes | 1-2 | 0.0 | 0 | 0 |
| C. Liuget | 1-0 | 0.0 | 0 | 0 |
| P. Rivers | 1-0 | 0.0 | 0 | 0 |
| C. Lynch | 1-0 | 0.0 | 0 | 0 |
| A. Garay | 0-1 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| San Diego | 7 | 0 | 9 | 7 |
| Denver | 0 | 17 | 7 | 6 |
| 1st Quarter | ||
| TD @ 6:52 | Eric Weddle makes a 23 yard interception return (Nick Novak kick is good). | |
| 2nd Quarter | ||
| TD @ 13:00 | Demaryius Thomas catches a 13 yard pass from Peyton Manning (Matt Prater kick is good). Drive: 6 plays, 56 yards in 2:20. | |
| FG @ 11:33 | Matt Prater makes a 19 yard kick. Drive: 4 plays, 7 yards in 1:14. | |
| TD @ 1:44 | Brandon Stokley catches a 31 yard pass from Peyton Manning (Matt Prater kick is good). Drive: 1 play, 31 yards in 0:07. | |
| 3rd Quarter | ||
| SAFETY @ 12:48 | Shaun Phillips. | |
| TD @ 7:23 | Eric Decker catches a 20 yard pass from Peyton Manning (Matt Prater kick is good). Drive: 3 plays, 25 yards in 0:18. | |
| TD @ 0:58 | Danario Alexander catches an 8 yard pass from Philip Rivers (Nick Novak kick is good). Drive: 12 plays, 80 yards in 6:25. | |
| 4th Quarter | ||
| FG @ 10:43 | Matt Prater makes a 30 yard kick. Drive: 10 plays, 67 yards in 5:15. | |
| FG @ 4:14 | Matt Prater makes a 32 yard kick. Drive: 11 plays, 57 yards in 4:56. | |
| TD @ 1:24 | Danario Alexander catches a 21 yard pass from Philip Rivers (Mike Scifres kick is good). Drive: 8 plays, 80 yards in 2:50. | |
| 4th Quarter | |
| 4-1-DEN 21 | (1:29) (Shotgun) P.Rivers pass deep left to D.Alexander for 21 yards, TOUCHDOWN. The Replay Assistant challenged the pass completion ruling, and the play was Upheld. |
| M.Scifres extra point is GOOD, Center-M.Windt, Holder-M.Scifres. | |
| N.Novak kicks onside 14 yards from SD 35 to SD 49. V.Green (didn't try to advance) to SD 49 for no gain (C.Lynch). | |
| 1-10-SD 49 | (1:23) R.Hillman left guard to SD 49 for no gain (D.Butler). |
| 2-10-SD 49 | (1:20) R.Hillman left tackle to SD 49 for no gain (K.Reyes). |
| 3-10-SD 49 | (1:16) R.Hillman left end to 50 for -1 yards (J.Johnson). |
| 4-11-50 | (:30) (Pass formation) PENALTY on DEN-B.Colquitt, Delay of Game, 5 yards, enforced at 50 - No Play. |
| 4-16-DEN 45 | (:30) B.Colquitt punts 42 yards to SD 13, Center-A.Brewer, fair catch by A.Cason. |
| 1-10-SD 13 | (:23) (Shotgun) P.Rivers pass short left to L.Green ran ob at SD 17 for 4 yards. |
| 2-6-SD 17 | (:17) (Shotgun) P.Rivers sacked at SD 12 for -5 yards (E.Dumervil). FUMBLES (E.Dumervil), and recovers at SD 12. P.Rivers to SD 12 for no gain (E.Dumervil). |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| P. Manning | 25/42 | 270 | 3 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| W. McGahee | 7 | 55 | 0 | 15 |
| R. Hillman | 12 | 43 | 0 | 21 |
| L. Ball | 6 | 35 | 0 | 14 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| B. Stokley | 4 | 55 | 1 | 31 |
| J. Tamme | 4 | 53 | 0 | 30 |
| D. Thomas | 3 | 42 | 1 | 17 |
| J. Dreessen | 4 | 28 | 0 | 11 |
| E. Decker | 2 | 23 | 1 | 20 |
| L. Ball | 3 | 21 | 0 | 11 |
| W. McGahee | 1 | 18 | 0 | 18 |
| R. Hillman | 2 | 16 | 0 | 12 |
| M. Willis | 2 | 14 | 0 | 10 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| T. Holliday | 1 | 0 | 0 | 0 |
| L. Ball | 1 | 1 | 1 | 0 |
| W. Woodyard | 0 | 0 | 1 | 12 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| M. Prater | 3/4 | 32 | 3/3 | 12 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| B. Colquitt | 5 | 50.4 | 1 | 58 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Holliday | 1 | 18.0 | 0 | 18 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Holliday | 3 | 7.3 | 0 | 9 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| C. Bailey | 8-0 | 0.0 | 0 | 0 |
| V. Miller | 7-0 | 3.0 | 0 | 2 |
| W. Woodyard | 5-3 | 0.0 | 1 | 0 |
| E. Dumervil | 4-2 | 1.0 | 0 | 1 |
| T. Carter | 4-1 | 0.0 | 0 | 0 |
| D. Williams | 3-1 | 0.0 | 0 | 0 |
| C. Harris | 3-0 | 0.0 | 0 | 0 |
| K. Vickerson | 3-0 | 0.0 | 0 | 0 |
| J. Bannan | 2-1 | 0.0 | 0 | 0 |
| R. Moore | 2-1 | 0.0 | 0 | 0 |
| D. Bruton | 1-0 | 0.0 | 0 | 0 |
| M. Unrein | 1-0 | 0.0 | 0 | 0 |
| D. Trevathan | 1-1 | 0.0 | 0 | 0 |
| O. Franklin | 1-0 | 0.0 | 0 | 0 |
| R. Ayers | 1-1 | 0.0 | 0 | 0 |
| N. Irving | 1-1 | 0.0 | 0 | 0 |
| K. Brooking | 1-0 | 0.0 | 0 | 0 |
| J. Leonhard | 0-0 | 0.0 | 1 | 0 |
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