| Passing | ||||
| CP/AT | YDS | TD | INT | |
| J. Campbell | 14/22 | 107 | 1 | 2 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| M. Forte | 21 | 63 | 0 | 8 |
| J. Campbell | 1 | 13 | 0 | 13 |
| M. Bush | 5 | 9 | 0 | 6 |
| A. Allen | 1 | 0 | 0 | 0 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| D. Hester | 3 | 23 | 0 | 9 |
| B. Marshall | 2 | 21 | 1 | 13 |
| K. Davis | 2 | 20 | 0 | 11 |
| M. Bush | 1 | 18 | 0 | 18 |
| A. Jeffery | 2 | 15 | 0 | 9 |
| E. Bennett | 1 | 6 | 0 | 6 |
| M. Forte | 3 | 4 | 0 | 4 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| J. Campbell | 2 | 0 | 1 | 0 |
| D. Hester | 1 | 0 | 0 | 0 |
| S. McManis | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| R. Gould | 0/0 | 0 | 1/1 | 1 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Podlesh | 5 | 46.8 | 1 | 53 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| D. Hester | 5 | 25.2 | 0 | 30 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| D. Hester | 3 | -0.3 | 0 | 4 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| M. Wright | 8-0 | 0.0 | 0 | 0 |
| C. Tillman | 5-2 | 0.0 | 0 | 0 |
| C. Conte | 5-0 | 0.0 | 0 | 0 |
| T. Jennings | 5-0 | 0.0 | 0 | 0 |
| L. Briggs | 4-2 | 0.5 | 0 | 0 |
| B. Urlacher | 3-4 | 0.0 | 0 | 0 |
| G. Hayes | 2-0 | 0.0 | 0 | 0 |
| J. Peppers | 2-0 | 0.0 | 0 | 0 |
| N. Roach | 2-1 | 0.5 | 0 | 0 |
| Z. Bowman | 2-0 | 0.0 | 0 | 0 |
| J. Thomas | 1-0 | 0.0 | 0 | 0 |
| A. Walters | 1-0 | 0.0 | 0 | 0 |
| D. Hester | 1-0 | 0.0 | 0 | 0 |
| K. Hayden | 1-0 | 0.0 | 0 | 0 |
| C. Steltz | 1-0 | 0.0 | 0 | 0 |
| I. Idonije | 1-1 | 0.5 | 0 | 0 |
| C. Wootton | 1-1 | 0.5 | 0 | 0 |
| S. Paea | 1-1 | 0.0 | 0 | 0 |
| A. Okoye | 0-1 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| Chicago | 0 | 0 | 7 | 0 |
| San Francisco | 10 | 10 | 7 | 5 |
| 1st Quarter | ||
| FG @ 10:32 | David Akers makes a 32 yard kick. Drive: 9 plays, 68 yards in 4:28. | |
| TD @ 6:14 | Vernon Davis catches a 3 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 4 plays, 63 yards in 2:16. | |
| 2nd Quarter | ||
| TD @ 12:40 | Kendall Hunter runs for 14 yards (David Akers kick is good). Drive: 8 plays, 96 yards in 4:00. | |
| FG @ 6:32 | David Akers makes a 37 yard kick. Drive: 8 plays, 25 yards in 4:47. | |
| 3rd Quarter | ||
| TD @ 11:05 | Michael Crabtree catches a 10 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 5 plays, 62 yards in 2:08. | |
| TD @ 3:43 | Brandon Marshall catches a 13 yard pass from Jason Campbell (Robbie Gould kick is good). Drive: 13 plays, 74 yards in 7:22. | |
| 4th Quarter | ||
| FG @ 11:46 | David Akers makes a 32 yard kick. Drive: 7 plays, 23 yards in 3:25. | |
| SAFETY @ 9:32 | Ray McDonald. | |
| 4th Quarter | |
| 2-1-CHI 42 | (4:28) (No Huddle, Shotgun) J.Campbell pass short middle to M.Forte to CHI 46 for 4 yards (N.Bowman). |
| 1-10-CHI 46 | (3:44) (No Huddle, Shotgun) M.Forte left guard to CHI 44 for -2 yards (R.Jean Francois). |
| 2-12-CHI 44 | (3:11) (No Huddle, Shotgun) J.Campbell pass incomplete deep left to B.Marshall. |
| 3-12-CHI 44 | (3:06) (Shotgun) J.Campbell pass short right to K.Davis to SF 45 for 11 yards (P.Willis). |
| 4-1-SF 45 | (2:25) (Shotgun) A.Allen up the middle to SF 45 for no gain (D.Dobbs). |
| 1-10-SF 45 | (2:18) A.Dixon left tackle to SF 49 for 4 yards (C.Wootton). |
| 2-6-SF 49 | (1:58) A.Dixon left tackle to 50 for 1 yard (A.Okoye; C.Tillman). |
| 3-5-50 | (1:31) A.Dixon right end to CHI 49 for 1 yard (L.Briggs). |
| 4-4-CHI 49 | (:28) PENALTY on CHI-J.Thomas, Neutral Zone Infraction, 5 yards, enforced at CHI 49 - No Play. |
| 1-10-CHI 44 | (:28) C.Kaepernick kneels to CHI 43 for 1 yard. |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| C. Kaepernick | 16/23 | 243 | 2 | 0 |
| K. Hunter | 0/0 | 0 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 17 | 78 | 0 | 14 |
| K. Hunter | 5 | 27 | 1 | 14 |
| C. Kaepernick | 4 | 12 | 0 | 5 |
| A. Dixon | 3 | 6 | 0 | 4 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| V. Davis | 6 | 83 | 1 | 32 |
| K. Williams | 2 | 60 | 0 | 57 |
| M. Manningham | 2 | 45 | 0 | 37 |
| M. Crabtree | 3 | 31 | 1 | 20 |
| R. Moss | 1 | 12 | 0 | 12 |
| D. Walker | 1 | 9 | 0 | 9 |
| K. Hunter | 1 | 3 | 0 | 3 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| C. Rachal | 1 | 1 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 3/3 | 37 | 3/3 | 12 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 4 | 47.0 | 4 | 54 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 3 | 21.0 | 0 | 23 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 4 | 4.8 | 0 | 12 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Bowman | 12-1 | 0.0 | 0 | 0 |
| A. Smith | 6-1 | 5.5 | 0 | 2 |
| P. Willis | 6-1 | 0.0 | 0 | 0 |
| D. Whitner | 4-1 | 0.0 | 0 | 0 |
| R. McDonald | 4-0 | 0.0 | 0 | 0 |
| C. Rogers | 3-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 2-1 | 0.0 | 0 | 0 |
| C. Culliver | 2-0 | 0.0 | 0 | 1 |
| T. Brown | 2-1 | 0.0 | 1 | 0 |
| R. Jean Francois | 2-0 | 0.0 | 0 | 0 |
| D. Goldson | 2-0 | 0.0 | 1 | 0 |
| B. Miller | 2-0 | 0.0 | 0 | 0 |
| J. Smith | 1-3 | 0.5 | 0 | 0 |
| D. Dobbs | 1-1 | 0.0 | 0 | 0 |
| T. Gooden | 1-0 | 0.0 | 0 | 0 |
| A. Brooks | 1-0 | 0.0 | 0 | 0 |
| T. Brock | 1-1 | 0.0 | 0 | 0 |
| P. Cox | 1-0 | 0.0 | 0 | 0 |
| C. Haggans | 1-0 | 0.0 | 0 | 0 |
| D. Walker | 0-1 | 0.0 | 0 | 0 |
| A. Dixon | 0-1 | 0.0 | 0 | 0 |
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