| Passing | ||||
| CP/AT | YDS | TD | INT | |
| B. Hoyer | 19/34 | 225 | 1 | 1 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| W. Powell | 14 | 52 | 0 | 10 |
| B. Hoyer | 1 | 6 | 0 | 6 |
| L. Stephens-Howling | 1 | -1 | 0 | -1 |
| A. Roberts | 1 | -2 | 0 | -2 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| M. Floyd | 8 | 166 | 1 | 53 |
| A. Roberts | 3 | 18 | 0 | 12 |
| L. Fitzgerald | 2 | 13 | 0 | 7 |
| J. Dray | 1 | 12 | 0 | 12 |
| J. King | 3 | 10 | 0 | 6 |
| S. Kelemete | 1 | 10 | 0 | 10 |
| W. Powell | 1 | -4 | 0 | -4 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| M. Floyd | 1 | 1 | 0 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| J. Feely | 2/2 | 35 | 1/1 | 7 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| D. Zastudil | 6 | 50.8 | 2 | 70 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. Stephens-Howling | 5 | 21.8 | 0 | 26 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| P. Peterson | 2 | 6.0 | 0 | 7 |
| A. Roberts | 1 | 5.0 | 0 | 5 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| D. Washington | 8-3 | 0.0 | 0 | 0 |
| D. Williams | 6-2 | 0.0 | 0 | 0 |
| A. Wilson | 5-1 | 0.0 | 0 | 0 |
| S. Bradley | 5-1 | 0.0 | 0 | 0 |
| K. Rhodes | 4-3 | 0.0 | 0 | 0 |
| P. Lenon | 4-0 | 0.0 | 0 | 0 |
| S. Acho | 3-1 | 0.0 | 0 | 0 |
| W. Gay | 3-1 | 0.0 | 0 | 1 |
| M. Adams | 2-0 | 0.0 | 0 | 0 |
| Q. Groves | 2-0 | 0.0 | 0 | 0 |
| C. Campbell | 2-0 | 1.0 | 0 | 0 |
| P. Peterson | 2-0 | 0.0 | 0 | 0 |
| D. Carter | 2-0 | 0.0 | 0 | 0 |
| J. Dray | 1-0 | 0.0 | 0 | 0 |
| J. Sanders | 1-0 | 0.0 | 0 | 0 |
| R. Johnson | 1-0 | 0.0 | 0 | 0 |
| A. Snyder | 1-0 | 0.0 | 0 | 0 |
| V. Holliday | 0-1 | 0.0 | 0 | 0 |
| 1 | 2 | 3 | 4 | |
| Arizona | 3 | 3 | 0 | 7 |
| San Francisco | 0 | 7 | 10 | 10 |
| 1st Quarter | ||
| FG @ 5:33 | Jay Feely makes a 35 yard kick. Drive: 7 plays, 37 yards in 2:27. | |
| 2nd Quarter | ||
| FG @ 13:44 | Jay Feely makes a 31 yard kick. Drive: 10 plays, 74 yards in 5:11. | |
| TD @ 7:20 | Michael Crabtree catches a 49 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 2 plays, 80 yards in 0:48. | |
| 3rd Quarter | ||
| FG @ 11:07 | David Akers makes a 43 yard kick. Drive: 9 plays, 54 yards in 3:53. | |
| TD @ 5:58 | Michael Crabtree catches a 7 yard pass from Colin Kaepernick (David Akers kick is good). Drive: 5 plays, 38 yards in 2:51. | |
| 4th Quarter | ||
| TD @ 12:59 | Frank Gore runs for 2 yards (David Akers kick is good). Drive: 12 plays, 72 yards in 6:23. | |
| FG @ 9:07 | David Akers makes a 26 yard kick. Drive: 9 plays, 26 yards in 3:42. | |
| TD @ 1:59 | Michael Floyd catches a 37 yard pass from Brian Hoyer (Jay Feely kick is good). Drive: 6 plays, 78 yards in 1:39. | |
| 4th Quarter | |
| 1-10-SF 23 | (3:00) (No Huddle, Shotgun) B.Hoyer pass incomplete deep right to M.Floyd. |
| 2-10-SF 23 | (2:55) (Shotgun) B.Hoyer pass incomplete short left to M.Floyd (T.Brock). |
| 3-10-SF 23 | (2:50) (Shotgun) B.Hoyer pass incomplete short right to A.Roberts [T.Jerod-Eddie]. PENALTY on ARZ-S.Kelemete, Offensive Holding, 10 yards, enforced at SF 23 - No Play. |
| 3-20-SF 33 | (2:43) (Shotgun) B.Hoyer pass short left to W.Powell to SF 37 for -4 yards (I.Williams). Caught at SF37. 0-yds YAC |
| 4-24-SF 37 | (2:06) (Shotgun) B.Hoyer pass deep right to M.Floyd for 37 yards, TOUCHDOWN. |
| J.Feely extra point is GOOD, Center-M.Leach, Holder-D.Zastudil. | |
| J.Feely kicks onside 9 yards from ARZ 35 to ARZ 44. R.Moss (didn't try to advance) to ARZ 44 for no gain (Z.Nash). PENALTY on ARZ-J.Sanders, Offside on Free Kick, 5 yards, enforced at ARZ 44. | |
| 1-10-ARI 39 | (1:58) L.James to ARZ 29 for 10 yards (D.Williams, K.Rhodes). |
| A.Smith kneels to ARZ 30 for -1 yards. | |
| A.Smith kneels to ARZ 31 for -1 yards. | |
| Passing | ||||
| CP/AT | YDS | TD | INT | |
| C. Kaepernick | 16/28 | 276 | 2 | 0 |
| A. Smith | 1/1 | 6 | 0 | 0 |
| Rushing | ||||
| ATT | YDS | TD | LG | |
| F. Gore | 20 | 68 | 1 | 9 |
| L. James | 7 | 49 | 0 | 26 |
| A. Dixon | 3 | 6 | 0 | 4 |
| C. Kaepernick | 3 | 5 | 0 | 7 |
| B. Miller | 2 | 3 | 0 | 2 |
| A. Smith | 2 | -2 | 0 | -1 |
| Receiving | ||||
| REC | YDS | TD | LG | |
| M. Crabtree | 8 | 172 | 2 | 49 |
| D. Walker | 2 | 50 | 0 | 27 |
| R. Moss | 2 | 28 | 0 | 20 |
| F. Gore | 3 | 21 | 0 | 14 |
| B. Miller | 1 | 6 | 0 | 6 |
| V. Davis | 1 | 5 | 0 | 5 |
| Fumbles | ||||
| NO | LST | REC | YDS | |
| L. James | 1 | 0 | 0 | 0 |
| D. Whitner | 0 | 0 | 1 | 0 |
| Kicking | ||||
| FG | LG | XP | PTS | |
| D. Akers | 2/4 | 43 | 3/3 | 9 |
| Punting | ||||
| NO | AVG | I20 | LG | |
| A. Lee | 4 | 46.2 | 1 | 56 |
| Kickoff Returns | ||||
| NO | AVG | TD | LG | |
| L. James | 1 | 33.0 | 0 | 33 |
| R. Moss | 1 | 0.0 | 0 | 0 |
| D. Walker | 1 | 3.0 | 0 | 3 |
| Punt Returns | ||||
| NO | AVG | TD | LG | |
| T. Ginn | 1 | 28.0 | 0 | 28 |
| Defense | ||||
| T-A | SCK | INT | FF | |
| N. Bowman | 4-1 | 0.0 | 0 | 0 |
| D. Whitner | 4-1 | 0.0 | 0 | 0 |
| P. Willis | 4-0 | 0.0 | 0 | 0 |
| I. Williams | 3-0 | 0.0 | 0 | 0 |
| I. Sopoaga | 3-0 | 0.0 | 0 | 0 |
| R. Jean Francois | 3-3 | 1.0 | 0 | 0 |
| A. Brooks | 3-0 | 1.0 | 0 | 0 |
| C. Culliver | 2-0 | 0.0 | 0 | 0 |
| M. Wilhoite | 2-0 | 0.0 | 0 | 0 |
| T. Brown | 2-1 | 0.0 | 1 | 0 |
| C. Rogers | 2-0 | 0.0 | 0 | 0 |
| A. Smith | 2-0 | 0.0 | 0 | 0 |
| T. Brock | 2-0 | 0.0 | 0 | 0 |
| D. Goldson | 2-0 | 0.0 | 0 | 0 |
| R. McDonald | 2-0 | 0.0 | 0 | 1 |
| D. McBath | 1-1 | 0.0 | 0 | 0 |
| A. Dixon | 1-0 | 0.0 | 0 | 0 |
| C. Spillman | 1-0 | 0.0 | 0 | 0 |
| L. Grant | 1-0 | 0.0 | 0 | 0 |
| B. Miller | 1-0 | 0.0 | 0 | 0 |
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