With Ayers out for a second straight week, George Selvie will likely slide over to left defensive end again, allowing Kerry Wynn to join the starting lineup as the right defensive end. Even against a run-heavy Bills team, the Giants defense will sorely miss its most effective pass-rusher.
Giants wide receiver Victor Cruz (calf) won't play Sunday against the 49ers, but he is aiming to return Week 6 against the Eagles, the New York Daily News reports.
Cruz is slated for an examination with team doctors Monday, which is 10 days removed from receiving a PRP injection in his left calf. After he meets with the doctors, he'll adjust his timetable for a return to running, according to The Record.
With a Monday night contest in Week 6, Cruz will have an extra day to prove the health of the calf. However, next Thursday's practice will ultimately set the groundwork for the potential to make his season debut.
Giants linebacker Devon Kennard (hamstring) has been ruled out for the game Sunday against the 49ers.
Kennard is off to an impressive start, with 25 tackles (15 solo) and an interception in four games. The Giants still don't have an every-down linebacker, but Kennard leads the group in snaps. In his absence, Mark Herzlich could get the start, though a bunch of players may benefit from added snaps.
George Selvie will be reunited with former University of South Florida teammate Jason Pierre-Paul in New York. The defensive lineman signed a one-year, $1.4 million deal with the Giants that includes a $200,000 signing bonus, according to Adam Schefter of ESPN.
Cowboys wide receiver Dez Bryant (foot) has been able to do some light running on a treadmill but has yet to run on the practice field, ESPN Dallas reports.
"[He's been] Getting in condition without putting too much stress and strain on his foot, so he has not been out running routes or anything like that up to this point," coach Jason Garrett said. "There are different ways to run where you can kind of get yourself in as good a shape as possible leading up to it, so he's been involved in that."
The Cowboys still haven't ruled out a return for Bryant in Week 7 following their bye, but that timetable seems extremely optimistic if he isn't able to put full weight on his surgically repaired foot yet. More likely, the wide receiver will be able to rejoin the lineup some time in November.
Butler served as the No. 4 wide receiver in a Week 4 loss to the Saints, catching one pass for 67 yards on his first target of the season. He had a chance to make it a touchdown, but he pulled up lame with the injury and was unable to reach the end zone. In Butler's absence, Rodney Whitehead will provide depth behind Terrance Williams, Devin Street and Cole Beasley.
Cowboys linebacker Sean Lee (concussion) has been designated as probable for the Sunday battle against New England.
Despite exiting with a concussion in the first half of the Week 4 loss to the Saints, Lee is on pace for 144 tackles. Facing a fast-paced, high-powered New England offense, Lee is one of the better Individual Defensive Player options this week. He's also one of the better options for the entire season, with his ability to stay healthy the only real concern.