CLEVELAND -- Manny Ramirez still reminds the Cleveland Indians of what he used to do for them.
Ramirez followed an intentional walk to David Ortiz with a tiebreaking, three-run homer in the eighth inning that lifted the Boston Red Sox to an 8-6 victory over the Indians on Tuesday night.
"That's Manny being Manny, because you know he's going to hit," Ortiz said. "Fans worry about him. Why? There's one thing Manny is known for -- hitting. Don't worry about Manny Ramirez."
The score was 5-5 when Kevin Youkilis singled off Guillermo Mota (0-1) with one out in the eighth and stole second. Mark Loretta popped out and Cleveland decided to walk Ortiz, who had homered an inning earlier.
"We figured we'd go after Manny and it didn't work out," Indians manager Eric Wedge said.
Ramirez, who left Cleveland after the 2000 season to sign a $160 million, eight-year contract with Boston, then hit a 1-0 pitch for his third homer of the season and 438th of his career, tying Andre Dawson for 32nd on the career list. After a slow start, Ramirez has hit .400 (14-for-35) with 10 RBI in his last 10 games to raise his average to .300.
Jonathan Papelbon pitched the ninth for his ninth save in nine chances, tying the major league record for saves by a rookie in April, set by Kansas City's Mike MacDougal in 2003.
Boston starter Curt Schilling failed in his quest to win his first five starts in a season for the first time in his 19-year career. He led 5-4 until Casey Blake doubled to open the seventh and scored on a single by Grady Sizemore.
"I felt strong," said Schilling, who threw 133 pitches -- his most in six years. "I had great stuff, a great split. This is one of those nights where the linescore doesn't match what was going on."
Schilling allowed five runs and nine hits in 6 2/3 innings, striking out eight and walking two as he failed to join Babe Ruth (1917) and Pedro Martinez (2000) as the only Red Sox pitchers with five April wins.
"The only disappointment is from my end," Schilling said. "People will bash the manager for leaving me in there, but it came down to me not making pitches. It was personally disappointing, but a great team win."
Manager Terry Francona said he never considered lifting Schilling after six innings.
"We won't do that every five days, but he was making pitches," Francona said. "He didn't talk me out of it because I never thought about it. With him, it goes beyond the ability to pitch. His heart is huge."
Keith Foulke (1-1) relieved Schilling and struck out Travis Hafner to end the seventh, then allowed Aaron Boone's two-out RBI double in the eighth.
Cleveland starter Jake Westbrook gave up two runs, six hits and six walks in five innings. The walks tied a career high, set against Toronto on Aug. 30, 2003.
Loretta's two-out, two-run single put Boston ahead 2-0 in the second, but Ben Broussard hit a two-run homer in the bottom half. Jason Michaels singled home a run in the third and scored on a two-out double by Hafner for a 4-2 lead.
Youkilis' sacrifice fly in the sixth and Ortiz tied it with his homer off the only pitch thrown by Scott Sauerbeck. His ninth homer -- and 900th career hit -- matched the Red Sox team record for April homers set by Ramirez in 2001.
"I threw a very good curveball, and he whacked it," Sauerbeck said.
Mike Lowell had an RBI single later in the inning, with Ramirez scoring as catcher Victor Martinez lost control of the ball when he applied the tag.
The Red Sox have won six straight at Jacobs Field since May 4, 2004. ... Westbrook caught Ramirez off second base in the third. Jason Varitek tried to advance from first on the play, and the Indians overthrew on the rundown and tagged him out at second before throwing back to third to catch Ramirez, with Martinez applying the tag. "Manny tooketh away, but he gaveth a lot more later," Francona joked. ... Ramirez has 10 homers and 33 RBI in his career against Cleveland. ... Schilling passed Hall of Famer Jim Bunning for 15th on the strikeout list with 2,863. ... Broussard went 3-for-4 and is hitting .463 (19-for-41) against right-handers.