David Ortiz and Manny Ramirez hit half of Boston's four homers and rookie closer Jonathan Papelbon earned his 19th save in as many chances as the Red Sox beat the Blue Jays 8-6 on Wednesday night in the finale of the three-game series.
"It's tough to get beat when you play like that," Ortiz said, referring to Boston scoring six runs on the four homers.
Ortiz and Ramirez went a combined 2-for-12 in the first two games of the series, but Ortiz homered in the first off Ted Lilly (5-5) and Ramirez hit a two-run homer off Francisco Rosario in the fifth.
Mark Loretta, who extended his hitting streak to 15 games with a two-run shot off Lilly in the third, and Trot Nixon also homered for the Red Sox. Nixon's solo shot off Pete Walker in the sixth made it 8-6.
"We needed this. That's what they've been doing to us," Boston manager Terry Francona said.
Jermaine Van Buren (1-0) pitched one inning for his first major league win.
Vernon Wells, who hit three homers in Toronto's 8-5 victory Tuesday, missed the game because of a sore left shoulder.
Lilly, who had won his previous six decisions against Boston, allowed five runs, five hits and four walks in four innings.
"I certainly don't believe we are content with just taking two out of three. Believe me, our intention was to finish this last game off," Lilly said. "I didn't really give us much of a chance coming out of there after four and leaving us down like that."
Lilly said he just didn't have command of his pitches.
Ortiz hit his 15th homer in the first and Toronto tied it in the second when Edgardo Alfonzo walked with the bases loaded.
Loretta's two-run homer gave Boston a 3-1 lead and Troy Glaus' RBI single off the left field wall cut it to 3-2 in the bottom half of the inning. Lilly's wild pitch allowed one run to score and Coco Crisp added an RBI single to make it 5-2 in the fourth.
Ramirez hit his 13th homer in the fifth.
Shea Hillenbrand's RBI infield single, Eric Hinske's run-scoring single and Aaron Hill's two-run triple into the gap in left center cut it to 7-6 in the bottom half.
David Pauley, called up by Boston from Double-A Portland to replace the injured David Wells, allowed six runs and 11 hits in 4 2-3 innings in his major league debut.
"I was definitely nervous," Pauley said. "I knew it was going to be tough. I thought I dealt with it pretty well. It's just a stepping stone to my next one."
Boston 3B Mike Lowell left the game in the sixth with a strained left hamstring. He's day to day. He said he hopes to play Friday. ... Toronto C Bengie Molina is day to day after getting hit on the right hand by a fastball from Josh Beckett on Tuesday. X-rays were negative.